Abstract：
:This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal nerves in chloralose-anesthetized, artificially ventilated rats. Almost all neurons (n = 119) were spontaneously active. Some responses consisted of high-frequency bursts while others consisted of fewer than 6 action potentials. Response onset latencies to renal nerve stimulation were consistent with activation by thinly myelinated or unmyelinated afferents. Several neurons in deeper laminae were inhibited by stimulation of renal afferents. Most neurons were located in laminae IV and V. Some were located in laminae I, VII and VIII. All neurons were located at spinal levels T10 to L1. Most neurons responded to both noxious and non-noxious mechanical cutaneous stimuli from relatively large receptive fields on the ipsilateral flank. Response latencies to cutaneous electrical stimulation were shorter than those to renal nerve stimulation. Neurons in intact and spinally transected rats responded with similar onset latencies and durations to renal nerve stimulation. However, neurons in spinally transected rats exhibited prolonged responses to cutaneous stimulation. Axons of 25% of the neurons projected through the cervical spinal cord in the ventrolateral funiculus. They had conduction velocities of 12-32 m/s. These data provide the first electrophysiological description of spinal projections of renal afferent fibers in the rat.
journal_name
Brain Resjournal_title
Brain researchauthors
Knuepfer MM,Akeyson EW,Schramm LPdoi
10.1016/0006-8993(88)91292-9subject
Has Abstractpub_date
1988-04-12 00:00:00pages
17-25issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)91292-9journal_volume
446pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.007
更新日期：2008-01-23 00:00:00
abstract：UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90847-4
更新日期：1986-02-05 00:00:00
abstract：:The distribution of [125I]hCGRP alpha binding sites was studied in tissue sections from rat brain and, at the level of the nucleus accumbens in the brains of 6 other species. In the rat, very high levels of binding were found in the nucleus accumbens, the amygdaloid complex and mammillary body while high amounts were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90686-p
更新日期：1991-01-18 00:00:00
abstract：:A direct, although transient, projection from the sensorimotor cortex to the cerebellum has been described previously in the neonatal kitten. The present report demonstrates that this pathway can be induced to persist into juvenile stages of the cat by partially denervating the deep cerebellar nuclei. Most of the cere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80021-x
更新日期：1986-11-01 00:00:00
abstract：:The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90663-t
更新日期：1992-02-07 00:00:00
abstract：:Glutamate carboxypeptidase II may modulate excitatory neurotransmission through the catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) and possibly other endogenous peptide substrates. To investigate the molecular properties of cloned human GCP II (hGCP II), we analyzed the NAAG-hydrolytic activity convey...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00244-3
更新日期：1998-06-08 00:00:00
abstract：:The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91983-6
更新日期：1994-11-21 00:00:00
abstract：:The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147118
更新日期：2020-12-01 00:00:00
abstract：:Immunohistochemistry was applied to examine the correlation between neuropeptide Y (NPY) and the two calcium binding proteins (CaBPs) parvalbumin (PV) and calbindin D28k (CB) in the trigeminal ganglion following peripheral axotomy of the inferior alveolar nerve (IAN) in the rat. Five days following transection and app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01262-1
更新日期：1996-01-29 00:00:00
abstract：:Ischemic-reperfusion injury in humans occurs in conditions such as stroke, cardiac arrest, subarachnoid hemorrhage or head trauma. Maximal tissue damage is observed during reperfusion, which is primarily attributed to oxidative injury resulting from production of oxygen free radicals. One of the major consequences of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00009-1
更新日期：1996-04-22 00:00:00
abstract：:The active and passive properties of petrosal ganglion sensory neurons with axons in the glossopharyngeal nerve were examined with intracellular microelectrodes in an in vitro preparation. Glossopharyngeal neurons could be classified into two groups: H-cells showing an inflexion or hump on the falling phase of the spi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91418-1
更新日期：1987-01-20 00:00:00
abstract：:Spinal administration of low doses of dynorphin, beta-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91069-9
更新日期：1987-01-27 00:00:00
abstract：:The effect of thyrotropin releasing hormone (TRH) administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v.) on the analgesic and hypothermic actions of U-50,488H, a highly selective kappa-opiate agonist, was determined in male Swiss Webster mice. Intraperitoneal administration of U-50,488H (8-32 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90144-c
更新日期：1993-10-15 00:00:00
abstract：:Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90346-4
更新日期：1985-01-28 00:00:00
abstract：:Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90251-7
更新日期：1982-07-15 00:00:00
abstract：:PGP 9.5 is a new cytoplasmic neuron-specific protein structurally and immunologically distinct from neuron-specific enolase. A specific antiserum has now shown that this protein is widely distributed in vertebrate brains and is also present in cells of the human diffuse neuroendocrine system. PGP 9.5 appears to be old...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90241-x
更新日期：1983-11-14 00:00:00
abstract：:Nerve cell dissociated from the cerebral cortex of mice were co-cultured with isolated pancreatic islets of Langerhans. After two weeks of co-culture, numerous axons had invaded the islets and differentiated nerve endings were closely juxtaposed to the endocrine islet cells. In contrast, no remnants of nerve cells wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90115-2
更新日期：1981-04-01 00:00:00
abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.061
更新日期：2007-10-10 00:00:00
abstract：:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.109
更新日期：2006-08-23 00:00:00
abstract：:Injury of peripheral nerves often results in hyperalgesia (an increased sensitivity to painful stimuli). This hyperalgesia is mediated in part by sympathetic neurotransmitters. We examined the effect of neuropeptide Y (NPY), specific Y1 and Y2 agonists, and an NPY antagonist on peripheral hyperalgesia in rats whose sc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01265-j
更新日期：1995-01-16 00:00:00
abstract：:Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural c...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.03.044
更新日期：2012-11-16 00:00:00
abstract：:Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction protein. We demonstrate here that similar alterations occur when nitrocel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00337-p
更新日期：1995-06-12 00:00:00
abstract：:The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.045
更新日期：2007-04-20 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of target genes. They derive from pre-miRNAs that are enzymatically processed by dicer to ∼22 nucleotide mature miRNAs. Members of the pre-miRNA lethal-7 (let-7) are known to regulate cell proliferation and apoptosis. Here, we showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.032
更新日期：2018-04-15 00:00:00
abstract：:Circular RNAs (circRNAs) are a class of covalently closed non-coding RNAs, and aberrant alteration of their expression patterns is studied in numerous diseases. This study aimed to investigate whether intracerebral hemorrhage (ICH) affected circRNA expression profiles in the rat brain. Adult male Sprague-Dawley rats w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146490
更新日期：2020-01-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91453-l
更新日期：1992-11-06 00:00:00
abstract：:Synaptic membrane (SM) and postsynaptic density (PSD) fractions isolated from the cerebral cortex (CTX) and cerebellum (CL) of the canine brain were found to contain one class of specific nitrendipine binding sites. The specific binding constants were: CTX-SM, Kd = 110 pM (Bmax = 126 fmol/mg protein); CTX-PSD, Kd = 20...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90008-2
更新日期：1986-11-01 00:00:00
abstract：:Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02542-3
更新日期：2003-06-13 00:00:00
abstract：:The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90305-3
更新日期：1989-10-23 00:00:00
