Abstract：
:Administration of either Tyr-D-Ala-Gly-MePhe-Gly(ol) (DAGO), a mu-opioid agonist, or nicotine into the VTA (A10) caused an increase in both dopamine (DA) and its metabolite levels in both the A10 region and DA nerve terminals in the nucleus accumbens of rats when assessed with dual probe brain dialysis. These findings show that DAGO and nicotine increase both axonal- and somatodendritic-DA release, as well as metabolic activity in mesolimbic DA neurons, possibly by inducing an increase in neuronal impulse flow.
journal_name
Brain Resjournal_title
Brain researchauthors
Yoshida M,Yokoo H,Tanaka T,Mizoguchi K,Emoto H,Ishii H,Tanaka Mdoi
10.1016/0006-8993(93)90087-4subject
Has Abstractpub_date
1993-10-08 00:00:00pages
277-80issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90087-4journal_volume
624pub_type
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