Abstract：
:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the presence of non-radioactive dopamine during photolysis, but was unaffected by the presence of sulpiride. Haloperidol preferentially reduced the labeling of the main band which had a molecular weight of about 57,000 rather than the other weakly labeled bands. Labeling of this 57,000 dalton protein was not apparent when rat cerebellar membranes were used and was markedly eliminated by kainic acid-induced lesions that destroyed the intrastriatal nerve cell bodies. These results indicate that this 57,000 dalton protein is the binding subunit of the D-1 dopamine receptor.
journal_name
Brain Resjournal_title
Brain researchauthors
Kuno T,Tanaka Cdoi
10.1016/0006-8993(81)90426-1subject
Has Abstractpub_date
1981-12-28 00:00:00pages
417-21issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90426-1journal_volume
230pub_type
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