Abstract：
:There is an abundance of evidence suggesting that the area postrema (AP) is involved in the central actions of arginine-vasopressin (AVP) and angiotensin II (Ang II) on cardiovascular regulation. Furthermore, recent studies have shown that activation of the AP facilitates the response of nucleus tractus solitarius (NTS) neurons to tractus stimulation. In the present study, using the perfused rabbit brain slice preparation, we examined the response of NTS neurons when AVP and Ang II were microinjected onto the AP. Spontaneous or solitary tract stimulation-induced neuronal activity was recorded extracellularly from the medial NTS before, during and after AVP or Ang II application. An increase or decrease in activity by more than 30% of the baseline value was considered excitatory or inhibitory. The effects of AVP were studied in 57 NTS cells, 14 of which were spontaneously active and 43 were driven by tract stimulation. Of the cells with evoked activity, 49% were excited, 19% were inhibited, and 32% did not respond. The percentage of cells responding to AVP was similar in spontaneously active cells. The effects of Ang II were tested in 85 cells including 54 with evoked activity and 31 with spontaneous activity. In NTS cells with evoked activity, AP application of Ang II caused inhibition in 37%, excitation in 7%, while 56% did not respond. The proportion of cells responding to Ang II was similar in spontaneously active cells. These results suggest that AVP may act on the AP to increase the excitatory response of NTS neurons while the actions of Ang II result in an inhibitory influence.
journal_name
Brain Resjournal_title
Brain researchauthors
Cai Y,Hay M,Bishop VSdoi
10.1016/0006-8993(94)91323-4subject
Has Abstractpub_date
1994-06-06 00:00:00pages
242-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91323-4journal_volume
647pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Microtubule-associated protein 1B (MAP1B) is expressed at high levels during development of the nervous system and is localized primarily in neurons while specific phosphorylated isoforms of MAP1B are localized exclusively in growing axons. The levels of MAP1B are down regulated in most regions of the adult CNS, but r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01148-8
更新日期：1999-03-27 00:00:00
abstract：:We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02238-6
更新日期：2000-01-10 00:00:00
abstract：:Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90659-5
更新日期：1983-05-05 00:00:00
abstract：:Activity of second-order relay neurons in the nucleus tractus solitarius (NTS) is regulated by peripheral and intrinsic synaptic inputs, and modulation of those inputs by metabotropic glutamate receptors (mGluRs) has been proposed. This study investigated effects of mGluR activation on glutamatergic transmission in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.031
更新日期：2014-09-18 00:00:00
abstract：:Single neurons in culture express a heterogeneity of neurotransmitter receptor subtypes. The study of the effects of neurotransmitters on neuronal function is complicated by this heterogeneity. It would therefore be useful to be able to identify live neurons that express the receptors of interest and then use these ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00436-2
更新日期：1996-08-26 00:00:00
abstract：:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91878-3
更新日期：1994-03-21 00:00:00
abstract：:The monoamine levels in the locus coeruleus (LC) were determined by HPLC following specific lesions of the ventral mesencephalic tegmental-A10 regions (VMT-A10) and raphé dorsalis (RD). Only lesions in the VMT-A10 area decreased the dopamine (DA) content, which strongly suggests that the projection from this region to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90327-x
更新日期：1983-03-21 00:00:00
abstract：:Electrical stimulation of the sural nerve (SN) revealed input from sural nerve afferents to L6 and L7 dorsal horn neurons that were not apparent using natural mechanical stimuli, especially in cells with variable latency responses to SN stimulation. Nearly all (31/32) cells that had reliable, fixed latency responses t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90816-4
更新日期：1986-04-16 00:00:00
abstract：:The effects of 2-day and 7-day cortisol treatment on immunoreactive corticotropin (ACTH) and beta-endorphin concentrations were measured in the cerebral cortex, hippocampus, hypothalamus, and cerebellum in male rats. Plasma ACTH, beta-endorphin, corticosterone, and cortisol levels were also measured in parallel. Corti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90853-6
更新日期：1989-06-12 00:00:00
abstract：:Simulated networks of excitatory and inhibitory neurons have previously been shown to reproduce critical features of experimental data regarding neural coding in V1, such as a positive relationship between thalamic input spike rate and the power of gamma frequency oscillations. This effect, referred to as modulated ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.070
更新日期：2012-01-24 00:00:00
abstract：:Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.062
更新日期：2008-01-29 00:00:00
abstract：:Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01783-7
更新日期：1999-09-11 00:00:00
abstract：:An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90615-6
更新日期：1976-03-12 00:00:00
abstract：:The rapid saltatory motion of intra-axonal particles detected by dark-field microscopy in myelinated axons isolated from sciatic nerves of adult Xenopus laevis was inhibited by colchicine or vinblastine at a concentration of larger than or equal to 0.1 mM. Both the predominant somatopetal transport and the somatofugal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90990-8
更新日期：1977-06-10 00:00:00
abstract：:The olfactory epithelium is comprised of bipolar sensory neurons, sustentacular cells, and basal cells. The sensory neurons have apical knobs and cilia, which project into the olfactory mucus toward the nasal lumen, and represent presumptive sites of odorant binding. Ionic currents, measured across this epithelium in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91153-r
更新日期：1991-04-12 00:00:00
abstract：:Calpain, a Ca(2+)-dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in SCI, we treated injured rats with E-64-d, a cell permeable and selec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02260-5
更新日期：2000-06-09 00:00:00
abstract：:We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01003-8
更新日期：1998-11-30 00:00:00
abstract：:The present study was designed to investigate the role of activation of Kca+2 channels and cAMP in opioid-induced pial artery dilation in newborn pigs equipped with closed cranial windows. Methionine enkephalin, an endogenous mu agonist, elicited dilation that was modestly attenuated by the Kca+2 channel antagonist, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01284-x
更新日期：1997-02-07 00:00:00
abstract：:In serum-free monolayer cultures of early postnatal weaver (wv/wv) cerebellum granule neurons show decreased attachment, survival and neurite outgrowth when compared to wild-type (+/+) littermate cultures. wv/wv Astrocytes display a more epithelioid morphology and altered proliferation. However, both morphology and pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90026-x
更新日期：1986-08-01 00:00:00
abstract：:Zinc-enriched (ZEN) neurons are distributed widely throughout the brain and spinal cord. Synaptic vesicle zinc in these neurons is thought to function as a neuromodulator upon its release into the synaptic cleft. Consistent with this possibility, zinc or zinc chelators can alter spatial learning, working memory, and n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03220-0
更新日期：2001-02-09 00:00:00
abstract：:Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90693-h
更新日期：1993-02-05 00:00:00
abstract：:The CNP neuropeptides (Command Neuron Peptides) were first found in the command neurons for withdrawal behavior in the terrestrial snail. Given the fact that certain peptides can be found in various invertebrates, we examined Drosophila brains to determine if CNP-like peptides were present. Two types of antisera were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.038
更新日期：2007-06-04 00:00:00
abstract：:Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90698-9
更新日期：1982-12-16 00:00:00
abstract：:Methylenedioxymethamphetamine (MDMA, Ecstasy) is a powerful releaser of serotonin. Increasing recreational use of this stimulant and hallucinogenic drug has raised concerns about its potential to produce brain damage. The vast majority of previous research studies have focused on the compound's ability to deplete sero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02563-0
更新日期：2003-06-06 00:00:00
abstract：:Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90088-5
更新日期：1993-10-08 00:00:00
abstract：:The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91532-1
更新日期：1989-01-02 00:00:00
abstract：:Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90653-6
更新日期：1987-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been described to have a role in the modulation of various genes involved in Abeta homeostasis, inflammation, and energy metabolism, making it a candidate gene for risk of Alzheimer's disease (AD). A functional polymorphism in exon 2 of the PPAR-gamma g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.034
更新日期：2009-09-29 00:00:00
abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.027
更新日期：2016-10-15 00:00:00
abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.066
更新日期：2008-03-04 00:00:00
