Abstract：
:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been described to have a role in the modulation of various genes involved in Abeta homeostasis, inflammation, and energy metabolism, making it a candidate gene for risk of Alzheimer's disease (AD). A functional polymorphism in exon 2 of the PPAR-gamma gene has been related to AD, but the effects are inconsistent across studies. To determine the role of PPAR-gamma in genetic susceptibility to AD in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for PPAR-gamma Pro12Ala polymorphism by polymerase chain reaction-restriction fragment length polymorphism method. We also examined the potential impact of this polymorphism on plasma level of soluble receptor for advanced glycation end products (sRAGE), a decoy receptor whose reduction has been associated with a higher risk of AD. Our results suggest that PPAR-gamma Pro12Ala polymorphism was not associated with an increased risk of AD in the overall sample. Stratification analysis revealed that the PPAR-gamma Pro/Ala genotype may be associated with the development of early-onset AD in the individuals without APOE epsilon4 allele (OR=3.76, 95% CI=1.10-12.84; p=0.03), but this association became insignificant after Bonferroni correction (p (corr)=0.10). Moreover, in the subgroup of APOE epsilon4 noncarriers, Kaplan-Meier survival analyses indicated that AD patients with the Pro/Ala genotype presented with disease onset 4.6 years earlier than carriers of Pro/Pro genotype. Further investigation revealed that AD patients carrying Pro/Ala genotype had significantly lower plasma sRAGE levels than patients with Pro/Pro genotype. These findings suggest that the functional PPAR-gamma Pro12Ala polymorphism may modify the age at onset of AD.
journal_name
Brain Resjournal_title
Brain researchauthors
Yao L,Li K,Zhang L,Yao S,Piao Z,Song Ldoi
10.1016/j.brainres.2009.07.034subject
Has Abstractpub_date
2009-09-29 00:00:00pages
133-9eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01439-5journal_volume
1291pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00856-l
更新日期：1995-10-23 00:00:00
abstract：:Corticofugal regulation of excitatory and inhibitory frequency tuning curves (FTCs) of neurons in the central nucleus of bat inferior colliculus (ICc) was studied by electrical stimulation of the primary auditory cortex (AC stimulation) under free field stimulation conditions using a two-tone inhibition paradigm. AC s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01786-2
更新日期：1999-09-11 00:00:00
abstract：:Experiments were performed in pigeons (Columba livia). Sympathetic preganglionic neurons (SPNs) in the first thoracic spinal cord segment (T1) were identified electrophysiologically using antidromic activation and collision techniques and then intracellularly labeled with horseradish peroxidase (HRP). In 6 of 10 HRP-l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91024-u
更新日期：1991-02-15 00:00:00
abstract：:Opiates and cannabinoids are among the most widely consumed habit-forming drugs in humans. Several studies have demonstrated the existence of interactions between both kind of drugs in a variety of effects and experimental models. The present study has been focused to determine whether perinatal delta9-tetrahydrocanna...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00766-5
更新日期：1998-10-05 00:00:00
abstract：:In the following study the behavioural effects of simultaneous lesion of the nucleus basalis magnocellularis (NBM) using ibotenic acid and noradrenergic depletion following a single i.p. administration of DSP4 (50 mg/kg) were examined in the rat. NBM lesion induced a deficit in acquisition of a reinforced T-maze alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91067-o
更新日期：1992-11-13 00:00:00
abstract：:We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01499-7
更新日期：1999-06-19 00:00:00
abstract：:We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90066-9
更新日期：1982-04-01 00:00:00
abstract：:The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91179-3
更新日期：1981-03-23 00:00:00
abstract：:The action of the epileptogenic agent pentylenetetrazol (PTZ) on a cloned potassium channel of the rat brain was studied. The Kv1.1 channel was expressed in oocytes of Xenopus laevis and potassium currents were investigated in outside-out and inside-out membrane patches. The results show that PTZ increased the multi-c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00181-3
更新日期：1996-05-25 00:00:00
abstract：:The uptake and efflux of 36Cl in the lateral ventricle choroid plexus of 1-7-week-old rats were measured to determine if Cl transport changed with age and if such transport responded to inhibitors of CSF secretion and ion transport. The steady-state (30 min) Cl uptakes were 148 +/- 9.4 nmol.mg-1 dry weight at 1 week a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90076-y
更新日期：1993-10-08 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) of human lower limb motor cortex paired with common peroneal nerve electrical stimulation produces a lasting modulation of motor cortex excitability following the principles of spike-timing-dependent plasticity. We previously demonstrated that this "paired associative stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.062
更新日期：2007-06-11 00:00:00
abstract：:Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by approximately 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclamide (i.c.v.) ab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01871-5
更新日期：1999-09-25 00:00:00
abstract：:Injections of HRP throughout the upper tectal strata led in 4 cases to the appearance of retrogradely labeled neurons within n.isthmi ventralis, contralateral to the experimental side. An additional case proved that this projection courses through the ventral supraoptic commissure. This is the first description of a c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90501-5
更新日期：1989-02-27 00:00:00
abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90705-2
更新日期：1975-03-21 00:00:00
abstract：:The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, beha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02453-7
更新日期：2000-07-14 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:We examined the involvement of tumor necrosis factor (TNF)-alpha on glutamate-induced cytotoxicity in a differentiated neuronal cell line. In this study, we used nerve growth factor (NGF)-differentiated PC12h cells. Glutamate cytotoxicity was assessed using the MTS and TUNEL assays. To detect TNF-alpha levels in cultu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.006
更新日期：2006-11-29 00:00:00
abstract：:Opioid antagonists block the positive hedonic response to food taste and are potent inhibitors of palatability-driven feeding. However, the specific brain regions within which opioid peptide secretion contributes to the maintenance of palatability-driven feeding have not been clearly established. In the present study,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00719-7
更新日期：1998-09-14 00:00:00
abstract：:Stimuli such as noise or hypoxia can induce a release of ATP into the cochlear fluid spaces. At nanomolar concentrations, ATP affects neurotransmission and electrochemical regulation of sound transduction. At higher concentrations, ATP may exert cytotoxicity acting on specific P2X(7) receptor subunits, thus contributi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.094
更新日期：2006-08-09 00:00:00
abstract：:Recently, cerebral blood flow changes were re-discussed to contribute to tissue protection after preconditioning. In the present study, we demonstrate increased vessel diameters of the leptomeningeal anastomoses after hypoxic preconditioning by visualization of the brain angioarchitecture using the latex perfusion tec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.081
更新日期：2006-10-18 00:00:00
abstract：:The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01052-9
更新日期：1996-12-16 00:00:00
abstract：:The response properties of neurons in the region of striate cortex subserving central retina (0 degrees-2 degrees) and in a region of representation of parafoveal retina (4 degrees-7 degrees) were studied in unanesthetized paralyzed macaque monkeys. Neurons sensitive to the orientation of the stimulus in the visual fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90240-1
更新日期：1975-12-12 00:00:00
abstract：:Xenopus laevis tadpoles functionally recover from spinal cord transection. Because this recovery requires the tadpole to metamorphose, it may result from compensatory changes initiated by de novo growth of axons involved in limb dominant locomotion rather than from regeneration of cut axons. To determine whether axona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.126
更新日期：2006-05-09 00:00:00
abstract：:There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed and the animals show complete loss of analgesic responses to morphine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02536-2
更新日期：2002-07-05 00:00:00
abstract：:Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90271-n
更新日期：1993-08-20 00:00:00
abstract：:gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91044-h
更新日期：1990-05-28 00:00:00
abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90171-6
更新日期：1989-04-03 00:00:00
abstract：:Basic fibroblast growth factor (FGF-2) isoforms of the adrenal medulla are differentially expressed during rat postnatal development. While the 18 and 23 kDa isoforms continuously rise towards the adult expression level, the 21 kDa isoform displays a peak expression at postnatal day 28. The peak expression of the 21 k...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00341-7
更新日期：1997-05-23 00:00:00
abstract：:The immunocytochemical localization of L-glutamate decarboxylase (GAD), the enzyme which which forms gamma-aminobutyric acid (GABA), has been studied in developing rodent cerebellum. During the first 3-4 postnatal days, GAD is distributed along non-terminal portions of axonal processes in close association with small ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90813-6
更新日期：1975-03-07 00:00:00
abstract：:The pharmacology of excitatory cholinergic responses in CA1 pyramidal cells was examined in detail using intracellular recording from the hippocampal slice preparation. Acetylcholine (ACh), carbachol, muscarine and pilocarpine depolarized the membrane potential with an associated increase in input resistance. In addit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90434-7
更新日期：1984-07-09 00:00:00
