Abstract：
:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region that show a change in activity that can be correlated with the occurrence of a nocifensive reflex (the tail-flick withdrawal response from noxious heat (TF)). Such cells have been previously demonstrated in the rostral ventromedial medulla (RVM). Extracellular single unit recording studies were made at sites from which it was possible to inhibit the TF with currents of 10 microA or less. Cellular response to 3 TF trials at 5 min intervals, and spontaneous activity over a 10 min period, were monitored for each unit. Of the cells encountered, 17% displayed an increase (on-cells) and 4% a decrease (off-cells) in activity that preceded the TF. The remaining cells were unaffected by the TF (neutral cells). On- and off-cells were found throughout the region from which TF suppression was observed but were most concentrated in the areas of the NCF and NPB. The presence of on- and off-cells in the NCF/NPB region as well as the RVM suggests that the input to RVM from NCF/NPB may be important in descending nociceptive modulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Haws CM,Williamson AM,Fields HLdoi
10.1016/0006-8993(89)90171-6subject
Has Abstractpub_date
1989-04-03 00:00:00pages
272-82issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90171-6journal_volume
483pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The recently identified neuropeptide QRFP(26) is predominantly expressed in the hypothalamus and was suggested to play a role in the regulation of food intake following the observation of an acute orexigenic effect after central administration in mice. QRFP(26) exerts its effect via GPR103 and a newly identified recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.055
更新日期：2006-11-13 00:00:00
abstract：:Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90479-7
更新日期：1993-11-26 00:00:00
abstract：:Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91096-1
更新日期：1987-05-19 00:00:00
abstract：:Using cervical sympathectomized and immobilized rabbits, the relationship between the luminance intensity and the magnitude of the response in pupillo-constrictor units of the ciliary nerve was investigated. It was revealed that the intensity--response relationship of the units closely resembled that of retinal recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90787-8
更新日期：1980-11-10 00:00:00
abstract：:Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.048
更新日期：2003-12-24 00:00:00
abstract：:The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03014-2
更新日期：2003-08-29 00:00:00
abstract：:We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems). In the tail-pinch test, the antinociceptive effect of DSIP was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91569-2
更新日期：1989-02-20 00:00:00
abstract：:Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to modulate a wide range of processes including attention, arousal, autonomic control and sensory processing. A spinal projection from the locus coeruleus (LC) is thought to regulate nociceptive processing. To characterize and selectivel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.023
更新日期：2016-06-15 00:00:00
abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90360-0
更新日期：1989-04-10 00:00:00
abstract：:Minor brain injury was inflicted with a small needle at 4 sites one week before the production of incomplete brain ischemia in the mouse. A bilateral carotid clamp was applied for 60 min under pentobarbital anesthesia, and the number of survivors at one week after the ischemic insult was compared with those in animals...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90091-0
更新日期：1986-09-03 00:00:00
abstract：:We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists on habenular Fos expression. Rats were inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01353-4
更新日期：1997-03-07 00:00:00
abstract：:The effect of increasing amounts of amyloid beta-protein (Abeta) on the number of neurons in the striatum was investigated in APPswe/PS1DeltaE9 transgenic mice. This mouse model of Alzheimer's disease-like amyloidosis displays an increased expression of Abeta in the brain with age. On the basis of reports of disruptio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.025
更新日期：2009-04-17 00:00:00
abstract：:The central axon of a primary afferent neuron that responded to light mechanical stimulation of the lower premolar teeth in a fast adapting fashion was intra-axonally injected with horseradish peroxidase in the cat. The labeled terminals within the rostrodorsomedial (Vo.r) and dorsomedial (Vo.dm) parts of subnucleus o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91588-j
更新日期：1993-03-19 00:00:00
abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03099-2
更新日期：2001-11-30 00:00:00
abstract：:The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91262-9
更新日期：1984-01-23 00:00:00
abstract：:Glucocorticoids (GCs) predispose hippocampal neurons to damage during metabolic stressors. One component of hippocampal GC-endangerment may be changes in neuronal defenses against oxidative challenge. Previous experiments showed a decrease in basal levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and glutathione...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00104-8
更新日期：1998-04-27 00:00:00
abstract：:In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90094-0
更新日期：1987-01-01 00:00:00
abstract：:Afferents from the nucleus reticularis thalami (RT) to the thalamic ventrobasal complex were studied in the rat by looking for degenerating terminals after selective neurotoxic lesion of RT using injections of kainic acid. Several lines of evidence are presented indicating that RT afferents terminate in the VB by F ty...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90607-8
更新日期：1983-07-04 00:00:00
abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90026-1
更新日期：1988-06-14 00:00:00
abstract：:In this study, we demonstrate the involvement of left frontoparietal cortices in neural processes for task-switching between skilled movements. Functional magnetic resonance imaging was conducted while thirty-two right-handed healthy participants performed two sequential finger-movement tasks with their left hands. On...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146365
更新日期：2019-11-01 00:00:00
abstract：:Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a reliable seed-based analysis of the resting-state brain activity to comprehensively delineate the subdivisions of striatal functional connectivity implicated in internet gaming disorder. Amon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.12.042
更新日期：2015-03-30 00:00:00
abstract：:A cluster of trigeminal nociceptive neurons was located in the lateral sulcus on the upper bank of the frontoparietal operculum in a region bordering between cortical areas SII and 7b. These neurons were isolated in cortical cell layers IV and V-VI. All nociceptive neurons responded exclusively to noxious mechanical s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90375-2
更新日期：1989-04-10 00:00:00
abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90864-9
更新日期：1985-11-04 00:00:00
abstract：:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03160-8
更新日期：2002-09-13 00:00:00
abstract：:Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00076-6
更新日期：1998-03-30 00:00:00
abstract：:The adrenergic transmitter norepinephrine (NE) dramatically increases the prominence of only two out of the hundreds of [35S]methionine-labeled pineal proteins resolved by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). One of these regulated proteins is AIP 37/6 (37 kDa, pI approximately 6). The labelin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01412-8
更新日期：1996-03-25 00:00:00
abstract：:The location of edema and territory of extravasation of serum protein were examined in the white matter of cats with different forms of intracranial pathology following an impact-acceleration injury to the head. Edema was tested with an organic density gradient and Evans blue dye was used as a marker for breakdown of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91611-7
更新日期：1985-06-24 00:00:00
abstract：:In the present study, receptor specific compounds were infused via a microdialysis probe in the vicinity of the right locus coeruleus (LC). During the infusion of these compounds, the extracellular content of noradrenaline was recorded in the ipsilateral medial prefrontal cortex (mPFC) with a second microdialysis prob...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01062-8
更新日期：1999-03-27 00:00:00
abstract：:We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91344-7
更新日期：1994-12-05 00:00:00
