Abstract：
:Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequently, regeneration in the two roots was assessed with one of two anatomical techniques. By anterograde tracing with horseradish peroxidase, the maximal rate of axonal regrowth towards the spinal cord was estimated to be 1.0 mm/day on the left and 3.1 mm/day on the right. Eighteen days after crush injury, new, thinly myelinated fibers in the root between crush site and spinal cord were 5-10 times more abundant ipsilateral to the sciatic nerve transection. The central axons of primary sensory neurons regenerate more quickly if the corresponding peripheral axons are also injured.
journal_name
Brain Resjournal_title
Brain researchauthors
Richardson PM,Verge VMdoi
10.1016/0006-8993(87)91096-1subject
Has Abstractpub_date
1987-05-19 00:00:00pages
406-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91096-1journal_volume
411pub_type
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