Abstract：
:To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neurons than control or cold-exposed animals. These observations add to the physiologic evidence that neurons of the preoptic area participate in thermoregulation and provide a means to identify the neurotransmitter systems involved.
journal_name
Brain Resjournal_title
Brain researchauthors
Scammell TE,Price KJ,Sagar SMdoi
10.1016/0006-8993(93)91280-6subject
Has Abstractpub_date
1993-08-06 00:00:00pages
303-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91280-6journal_volume
618pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91327-6
更新日期：1983-04-11 00:00:00
abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.058
更新日期：2009-03-09 00:00:00
abstract：:The effect of cerebellar stimulation on the accommodation of the lens was examined in anesthetized cats. An infrared optometer was used to measure the refractive power of the lens during stimulation of the cerebellum. The area giving responses within latencies shorter than 160 msec and amplitudes larger than 0.15 diop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90334-7
更新日期：1978-09-29 00:00:00
abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90129-7
更新日期：1989-12-25 00:00:00
abstract：:(1) After inoculation of the pseudorabies virus in the anterior chamber of the eye of the rat, virions can be found only in the neurons of the superior cervical sympathetic ganglion and in the sensory ganglion of the fifth nerve on the inoculated side. Other nervous structures--central or peripheral--are not infected....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90241-x
更新日期：1978-01-20 00:00:00
abstract：:The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's disease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91401-0
更新日期：1986-01-01 00:00:00
abstract：:Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03200-5
更新日期：2001-02-09 00:00:00
abstract：:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02881-0
更新日期：2002-07-19 00:00:00
abstract：:The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC 3.4.11.8) (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90309-2
更新日期：1982-06-24 00:00:00
abstract：:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91050-7
更新日期：1981-10-19 00:00:00
abstract：:The characterization of motor and cognitive dysfunctions following a neonatal ischemic injury is a prerequisite to investigate putative pharmacological interventions. To this end, in the present study, we evaluated the long-lasting behavioral alterations occurring after a hypoxic/ischemic injury obtained by the combin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01997-1
更新日期：2000-03-24 00:00:00
abstract：:Locomotor stepping elicited by lateral hypothalamic stimulation in the anesthetized rat is blocked by lesions in the anterior ventromedial midbrain. This study determined in acute experiments whether the dorsal midbrain regions implicated in locomotion were also part of the necessary pathway. Rats were anesthetized wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91049-3
更新日期：1987-01-27 00:00:00
abstract：:Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90128-4
更新日期：1987-02-10 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. To gain an insight into the mechanisms underlying the progression of PD, gene expression analysis was performed using two different brain regions, the substantia nigra pars compacta (SN) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.066
更新日期：2010-07-30 00:00:00
abstract：:Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.042
更新日期：2009-12-11 00:00:00
abstract：OBJECTIVE:The modern brain imaging studies in patients with eating disorders have shown that neurotransmitting regulation differs distinctly from control groups. These disturbances have involved serotonin and dopamine system can be inherited and conditioned by genes. The aim of this work has been the analysis of associ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.035
更新日期：2010-01-11 00:00:00
abstract：:Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90728-5
更新日期：1979-07-27 00:00:00
abstract：:In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90562-6
更新日期：1984-04-16 00:00:00
abstract：:The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00548-4
更新日期：1998-08-10 00:00:00
abstract：:Ionizing radiations induce oxidative stress on target tissues, mainly through the generation of reactive oxygen species (ROS). However, there are few data available on the behavioral effects of moderate doses of ionizing radiation. The aim of the present work was to evaluate the performance of adult rats irradiated at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.053
更新日期：2010-02-02 00:00:00
abstract：:Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90693-h
更新日期：1993-02-05 00:00:00
abstract：:Transient global ischemia induces selective, delayed neuronal death of pyramidal neurons in the hippocampal CA1. Whereas long term treatment of middle-aged female rats with estradiol at physiological doses ameliorates neuronal death, the signaling pathways that mediate the neuroprotection are, as yet, unknown. Protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.036
更新日期：2012-08-30 00:00:00
abstract：:Aggression is a major source of social stress with negative effects on health and well-being, yet limited information is known about the molecular mechanisms mediating aggressive behavior in swine. Ractopamine (RAC) is a β-adrenoreceptor agonist that enhances growth but increases aggressive behaviors in female pigs. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.035
更新日期：2011-03-24 00:00:00
abstract：:In animal models, the hallmark of a hypoxic condition is a strong negative shift of the DC potential (anoxic terminal negativity, ATN). This DC-shift is interpreted to be primarily due to a breakdown of the membrane potential of neurons. Such massive neuronal depolarizations have not been reported for all human neocor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00911-0
更新日期：1996-11-25 00:00:00
abstract：:Current and voltage clamp recordings were made with a patch-clamp technique from large, light, dorsal root ganglia (DRG) neurons in tissue culture, derived from trisomy 16 and normal fetal mice. In a Na gradient of [52 mM]o/[28 mM]i, the action potential was accelerated, depolarization and repolarization were faster a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90052-1
更新日期：1988-02-01 00:00:00
abstract：:Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80031-8
更新日期：1987-04-28 00:00:00
abstract：:The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS) also in noise induced hearing loss (NIHL) and anti-oxidants and free-radicals scavengers have been shown to attenuate the damage. Coenzyme Q(10) (CoQ(10)) or ubiquinone has a bioenergetic role as a component of the mithocondrial ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.027
更新日期：2009-02-27 00:00:00
abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.056
更新日期：2007-02-09 00:00:00
abstract：:Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the main histopathological characteristic of Parkinson's disease. We studied the electrophysiological characteristics of the spontaneous activity of substantia nigra pars compacta dopaminergic neurons in rats with a partial, unil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.052
更新日期：2006-04-21 00:00:00
abstract：:We have investigated sensitivity to the conditioned fear procedure of mice is influenced by the genetic deletion of alpha2A adrenoceptors (ARs). We observed a heightened freezing response in the discrete cue memory test in alpha2A AR knockout (alpha2A AR KO) mice and in D79N mice, a transgenic mouse strain with functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03248-7
更新日期：2003-10-03 00:00:00
