Abstract:
OBJECTIVE:The modern brain imaging studies in patients with eating disorders have shown that neurotransmitting regulation differs distinctly from control groups. These disturbances have involved serotonin and dopamine system can be inherited and conditioned by genes. The aim of this work has been the analysis of association between eating disorders of anorexia or bulimia type and two polymorphisms of COMT gene. The additional goal has been the analysis of correlation among chosen personality and psychological features of ED women with the research gene variations. METHODS:The group taken as research sample consisted of adult 103 women (mean age=22.45+/-3.8 years) suffered from serious ED with illness lasting minimum 12 months. According to ICD-10 criteria, 61 women were diagnosed as anorexia nervosa while as 42 bulimia nervosa. The control group consisted of 108 ethnically and age-matched women with excluded major psychiatric disorders. The study groups were filling up the Eating Disorders Inventory and the Temperament and Character Inventory. The genotype of catechol-O-methyltransferase in two polymorphisms rs4633 (his102his) and rs4680 (val158met) was determined. RESULTS:The joined GGCT genotype increased the risk of having ED over fivefold and over sevenfold the risk of having bulimia. Also haplotype CT was found three times more often in ED women than in controls. Besides the homozygous genotypes, AACC and GGCC reduced substantially the relative risk of ED. The patients with the low activity COMT genotype scored higher in EDI scales ineffectiveness, drive for thinness and perfectionism. The high activity genotype was connected with underdeveloped features of character marked in the poor cooperativeness and the poor self-directedness. These connections among genotypes and character scales were more expressed in bulimia group.
journal_name
Brain Resjournal_title
Brain researchauthors
Mikołajczyk E,Grzywacz A,Samochowiec Jdoi
10.1016/j.brainres.2009.10.035subject
Has Abstractpub_date
2010-01-11 00:00:00pages
142-8eissn
0006-8993issn
1872-6240pii
S0006-8993(09)02213-6journal_volume
1307pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We previously reported that the level of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta proteins increases with postnatal age. In the present study, we investigated the developmental changes in whole protein substrates of CaM kinase II as compared with those of cAMP-dependent protein kinase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90861-3
更新日期:1994-10-03 00:00:00
abstract::The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146798
更新日期:2020-07-01 00:00:00
abstract::Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cort...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1991-04-26 00:00:00
abstract::Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.036
更新日期:2007-03-16 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.054
更新日期:2011-01-12 00:00:00
abstract::Damage to the cerebral endothelium from ischemia could exacerbate brain injury by altering vascular integrity, but little is known concerning the response of cerebral endothelial cells to hypoxia. To address this issue, cerebral capillary endothelial cells were isolated from 14-day-old rats, grown to confluence, and p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90367-0
更新日期:1994-08-08 00:00:00
abstract::Focal axonal swellings are characteristic of a wide range of neuropathies. Three neuron-specific monoclonal antibodies have been used to identify focal axonal swellings in the normal developing rat cerebellar cortex. Between 7 and 15 days postnatal, swellings are a common feature of the granular layer and white matter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91018-8
更新日期:1986-01-22 00:00:00
abstract::The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00423-n
更新日期:1995-07-17 00:00:00
abstract::Immobilization of frogs for 1 h induces analgesia which is blocked but not reversed by low doses of naloxone. After 9 days of daily immobilization for 1 h, the treatment fails to cause analgesia thus indicating that tolerance has developed. Animals tolerant to immobilization-induced analgesia do not show cross-toleran...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90073-8
更新日期:1984-04-02 00:00:00
abstract::A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00542-3
更新日期:1998-08-17 00:00:00
abstract::Previous research with deafferented subjects suggests that efference copy can be used to update limb position. However, the contributions of efference copy to limb localization are currently unclear. We examined the performance of JDY, a woman with severe, longstanding proprioceptive deficits from a sensory peripheral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.063
更新日期:2010-10-08 00:00:00
abstract::Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91593-3
更新日期:1986-03-05 00:00:00
abstract::Intracerebral administration of 6-hydroxydopamine (6-HDA) along the dorsal noradrenergic bundle produced a gradual and long-lasting decrease of norepinephrine (NE) in hippocampus. This decrease in NE levels initially was accompanied by a parallel decrease in the activity of the rate-limiting enzyme for NE biosynthesis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90056-8
更新日期:1984-12-24 00:00:00
abstract::In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02328-3
更新日期:2000-06-23 00:00:00
abstract::Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful stimulus in the absence of inflammation remains unknown. Thus, we evaluated the involvement of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.044
更新日期:2011-04-18 00:00:00
abstract::Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were fou...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90360-7
更新日期:1976-10-22 00:00:00
abstract::We studied the effects of transcranial magnetic stimulation (TMS) on muscle activation patterns and joint kinematics during oscillatory movements of a joint within a two-joint (elbow-wrist) synergy. Healthy young adults (N=8) performed cyclic movements in one of the joints while the other joint was or was not involved...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03958-6
更新日期:2003-01-31 00:00:00
abstract::Intradentate administration of colchicine has been reported to affect the cholinergic muscarinic system in the hippocampus, causing a reduction in quinclidinylbenzilate binding sites and an increase in choline acetyltransferase activity. Since the cholinergic muscarinic system is coupled to the formation of inositolph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91419-4
更新日期:1989-01-16 00:00:00
abstract::The mammalian circadian clock located in the suprachiasmatic nuclei (SCN) continues to oscillate when isolated in a brain slice preparation, and can be phase shifted in vitro by a variety of serotonergic (5-HTergic) agents. We have previously shown that 5-HT and a 5-HT agonist, quipazine, induce phase advances in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90348-4
更新日期:1994-04-25 00:00:00
abstract::In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90286-9
更新日期:1976-08-13 00:00:00
abstract::Reducing external calcium from 1.0 to 0.1 mM increased the flash sensitivity and the time-to-peak (tp) of linear responses of rod photoreceptors. The quantitative relation between flash sensitivity and tp was the same as during light adaptation. However, the calcium ionophore A23187 reduced sensitivity without affecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90405-6
更新日期:1985-04-15 00:00:00
abstract::Experiments were performed which demonstrate that low power, pulsed microwave exposure induces a significant increase in local cerebral blood flow within the brain of the conscious rat. Previous studies purporting to examine changes in brain vascular permeability induced by microwave radiation must be re-evaluated in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90668-5
更新日期:1981-01-05 00:00:00
abstract::A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91641-6
更新日期:1987-12-29 00:00:00
abstract::The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90098-3
更新日期:1986-09-03 00:00:00
abstract::Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential impor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01191-9
更新日期:1999-04-10 00:00:00
abstract::There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/0165-0173(85)90010-4
更新日期:1985-06-01 00:00:00
abstract::Compelling evidence from experimental animal disease models and early-phase clinical trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path towards the development of clinically applicable exogenous stem cell therapies. Building from current advances in the field of NSC biology a...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2019.146615
更新日期:2020-02-15 00:00:00
abstract::The actions of pentobarbital (PB) and diphenylhydantoin (DPH) have been studied on neurons of dorsal root ganglia from adult rats. At anesthetic level (i.e. 1--2 x 10(-4) M), PB greatly enhanced neuronal responses to gamma-aminobutyric acid (GABA); at 10(-3) M PB caused a small depolarization and profoundly attenuated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90370-x
更新日期:1981-03-02 00:00:00
abstract::ERPs were acquired in the test phases of three memory experiments, where three classes of word were presented. These were: (i) words encountered in a prior study phase (studied words), (ii) words presented at test for the first time (new words), and (iii) new words repeated after a lag of 7-9 intervening words (repeat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.095
更新日期:2006-10-09 00:00:00
abstract::The influence of extracellular sinusoidal electric fields on the amplitude of population spikes evoked by single test pulses in excitatory pathways to CA1 pyramidal neurons was studied in rat hippocampal slices. The fields in the tissue were of the order of EEG gradients. Stimulation at 5 Hz, a frequency representativ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90293-2
更新日期:1984-12-10 00:00:00