Abstract：
:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the spinal cord in untreated, colchicine-treated, and adrenalectomized (ADX) male rats. In untreated animals, very few CRF-stained cells were retrogradely labeled after tracer injections in either target, while a modest number, comparable to that seen in previous studies, of vasopressinergic cells were found to project to one or both structures. Animals pretreated with colchicine, a non-specific inhibitor of axonal transport, displayed CRF immunoreactivity in a small percentage of retrogradely labeled neurons in the PVH; the number of retrogradely labeled vasopressin-immunoreactive cells was comparable to that seen in untreated rats. Despite the fact that ADX animals displayed enhanced immunostaining for both peptides in the parvocellular division of the PVH, the number of retrogradely labeled cells stained for each peptide was similar to that seen in controls. The results establish that CRF is contained within the long descending projections of the PVH, and are consistent with the view that adrenal steroid withdrawal preferentially enhances the expression of CRF and vasopressin in parvocellular neurosecretory neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Sawchenko PEdoi
10.1016/0006-8993(87)91641-6subject
Has Abstractpub_date
1987-12-29 00:00:00pages
253-63issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91641-6journal_volume
437pub_type
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