Abstract：
:Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was antagonized in both hemispheres by the D2 antagonist eticlopride, but not by the D1 antagonist SCH 23390. In neurologically intact rats, the D1 agonist SKF 38393, which alone did not elicit pallidal Fos expression, augmented the quinpirole-induced Fos response. Thus, D1 agonists can synergize with D2 agonists in inducing GP c-fos; but the D2-stimulated induction does not depend on concurrent D1 agonism.
journal_name
Brain Resjournal_title
Brain researchauthors
Marshall JF,Cole BN,LaHoste GJdoi
10.1016/0006-8993(93)91166-psubject
Has Abstractpub_date
1993-12-31 00:00:00pages
308-13issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91166-Pjournal_volume
632pub_type
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