Prolonged antinociception following carbon dioxide anesthesia in the laboratory rat.


:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) antinociception. Control animals, placed in the same chamber filled with air, showed no such effects. Rats exposed to 70% CO2 exhibited effects on the hot plate comparable to those seen after inhalation of 100% CO2, indicating that the response is not due to CO2-induced hypoxia. Additionally, recovery from halothane-induced anesthesia of comparable duration did not result in antinociception, confirming that anesthesia alone is not sufficient to produce the effect. Pretreatment with the opiate antagonist naltrexone (0.1-10 mg/kg i.p.) did not diminish the CO2-induced antinociception, suggesting that endogenous opioids are not obligatory in the mechanism of this response. Furthermore, hypophysectomy abolished hot-plate antinociception in animals exposed to 100% CO2 while sham-treated controls exhibited a pattern of hot-plate responses similar to that reported above. Taken together, these findings show that: (1) recovery from CO2-induced anesthesia results in a prolonged mild antinociception, detectable with thermal and mechanical nociceptive tests; and (2) this response may represent a novel from of environmentally induced antinociception, mediated by a non-opiate hormonal substance.


Brain Res


Brain research


Mischler SA,Alexander M,Battles AH,Raucci JA Jr,Nalwalk JW,Hough LB




Has Abstract


1994-03-21 00:00:00














  • Transition from ischemic neuronal necrosis to infarction in repeated ischemia.

    abstract::To study morphological changes in the cortex that follow repeated ischemia, one, two, and three 7-min unilateral occlusions of the carotid artery at 6-h intervals, and three, four, and five 7-min similar occlusions at 12-h intervals were produced in gerbils. Animals with one and two 7-min occlusions at 6-h intervals s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hanyu S,Ito U,Hakamata Y,Yoshida M

    更新日期:1995-07-17 00:00:00

  • Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats.

    abstract::The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

    更新日期:1999-10-16 00:00:00

  • An autoradiographic study of the formation of the lateral motor column in the chick embryo.

    abstract::An autoradiographic determination of the time of origin of the lateral motor columns (LMC) of the chick embryo has been made. The first motor neurons of the brachial LMC are born at stage 15; the earliest birthdates of lumbar LMC neurons are at stage 17. At least 95% of the motor neurons of both brachial and lumbar co...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hollyday M,Hamburger V

    更新日期:1977-08-26 00:00:00

  • Attenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture model.

    abstract::Sustained neuroinflammation contributes to the pathogenesis of postoperative cognitive dysfunction. Dexmedetomidine, a selective α-2 adrenergic receptor agonist, exhibits a protective role in the brain. This study investigated whether dexmedetomidine pretreatment attenuates neuroinflammation induced by tibial fracture...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhu YJ,Peng K,Meng XW,Ji FH

    更新日期:2016-08-01 00:00:00

  • Effects of intra-amygdala injections of NMDA receptor antagonists on acquisition and retention of inhibitory avoidance.

    abstract::These experiments examined the effects of intra-amygdala injections of NMDA receptor antagonists on the acquisition and retention of inhibitory avoidance. In Expt. I, rats received bilateral intra-amygdala injections of the NMDA antagonists D,L-AP5 (1-10 micrograms), D-AP5 (0.03-1 micrograms), CPP (0.125 or 0.375 micr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kim M,McGaugh JL

    更新日期:1992-07-10 00:00:00

  • Calcitonin gene-related peptide projection from the ventromedial thalamic nucleus to the insular cortex: a combined retrograde transport and immunocytochemical study.

    abstract::We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wh...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shimada S,Shiosaka S,Hillyard CJ,Girgis SI,MacIntyre I,Emson PC,Tohyama M

    更新日期:1985-09-30 00:00:00

  • Relationships between neurons expressing neuronal nitric oxide synthase, degree of microglia activation and animal survival. A study in the rat cortex after transient ischemia.

    abstract::The focal ischemia obtained in an animal model of middle cerebral artery occlusion (MCAo) causes the "core" of damage in the striatum and the "penumbra" of damage in the fronto-parietal cortex. The latter is mainly functionally affected and shows changes in nNOS and iNOS expression during the acute phase of ischemia. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vannucchi MG,Bizzoco E,Corsani L,Gianfriddo M,Pedata F,Faussone-Pellegrini MS

    更新日期:2007-02-09 00:00:00

  • Organization of layers II-III connections in human visual cortex revealed by in vitro injections of biocytin.

    abstract::In the search for cortical mechanisms subserving psychological phenomena, a better understanding of human cortical circuitry is crucial. In this report we describe aspects of intrinsic connectivity of supragranular layers in human visual cortex, revealed by extracellular injections of the anterograde tracer biocytin i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kenan-Vaknin G,Ouaknine GE,Razon N,Malach R

    更新日期:1992-10-30 00:00:00

  • Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration.

    abstract::Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. The present ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hemby SE,Horman B,Tang W

    更新日期:2005-12-07 00:00:00

  • Brain extracts that promote the proliferation of neuroblasts from chick embryo in culture.

    abstract::The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Barakat I,Sensenbrenner M

    更新日期:1981-06-01 00:00:00

  • Long-lasting effects of naltrexone, an opioid receptor antagonist, on cell proliferation in developing rat forebrain.

    abstract::Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmahl W,Funk R,Miaskowski U,Plendl J

    更新日期:1989-05-08 00:00:00

  • Characterization of metorphamide-like immunoreactivity in the zona incerta and lateral hypothalamus: co-localization with alpha-melanocyte-stimulating hormone-like immunoreactivity.

    abstract::Double-staining in either vibratome or paraffin sections using contrasting chromogens revealed an alpha-melanocyte-stimulating hormone (alpha-MSH)-containing cell group in the arcuate nucleus, a metorphamide-containing cell group in the paraventricular hypothalamus, and an extensive group of magnocellular perikarya in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Merchenthaler I,Maderdrut JL,Weber E,Petrusz P

    更新日期:1988-06-14 00:00:00

  • Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice.

    abstract::Interpretation of the cellular and molecular pathogenic basis of post-minimal traumatic brain injury is a significant clinical and scientific problem, especially due to the high prevalence of motor vehicle--and other accidents. Pathogenetic brain mechanisms following traumatic impact are usually investigated by using ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tashlykov V,Katz Y,Gazit V,Zohar O,Schreiber S,Pick CG

    更新日期:2007-01-26 00:00:00

  • The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain.

    abstract::The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat foreb...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Frankel PS,Cunningham KA

    更新日期:2002-12-27 00:00:00

  • Tachykinins protect cholinergic neurons from quinolinic acid excitotoxicity in striatal cultures.

    abstract::The neuroprotective effect of tachykinins against excitotoxic death of cholinergic neurons was studied in rat striatal cell cultures. Quinolinic acid (QUIN) and kainic acid (KA) produced a dose dependent decrease in choline acetyltransferase activity, but KA was more potent. Our results show that substance P (SP) tota...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Calvo N,Reiriz J,Pérez-Navarro E,Alberch J

    更新日期:1996-11-18 00:00:00

  • Kindling of the ventral tegmental area induces supersensitivity in the central dopamine system.

    abstract::Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimulations (100 microA at 1 min intervals) delivered once per day for 14 c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Watanabe T,Morimoto K,Nakamura M,Hirao T,Ninomiya T,Ando N,Suwaki H

    更新日期:2004-04-02 00:00:00

  • The entopeduncular nucleus: Golgi morphometrics of serially reconstructed neurons in adult cats.

    abstract::Computer-assisted morphometrics were used to characterize mature somatodendritic architecture in Golgi-stained neurons of the entopeduncular nucleus (EN) of the adult cat. Only one form of adult EN neuron was apparent and characterized by common features including: relatively large conical somata, long aspiny and mode...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dvergsten CL,Hull CD,Levine MS,Adinolfi AM,Fisher RS,Buchwald NA

    更新日期:1986-06-11 00:00:00

  • Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model.

    abstract::Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kang JM,Park HJ,Choi YG,Choe IH,Park JH,Kim YS,Lim S

    更新日期:2007-02-02 00:00:00

  • The superior cervical ganglia are not necessary for entrainment or persistence of the pineal melatonin rhythm in Japanese quail.

    abstract::The avian pineal exhibits a daily rhythm in the synthesis and secretion of the hormone, melatonin, which is involved in maintaining temporal order within the circadian system of some species. The pineal is richly innervated by sympathetic nerves which originate in the superior cervical ganglia (SCG) and, in the chicke...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Barrett RK,Underwood H

    更新日期:1992-01-13 00:00:00

  • Influence of a 1-h immobilization stress on sleep and CLIP (ACTH(18-39)) brain contents in adrenalectomized rats.

    abstract::Basal sleep amounts in adrenalectomized rats (AdX), as compared to intact animals, exhibit a significant increase in slow-wave sleep (SWS), a tendency towards an increase in paradoxical sleep (PS), and circadian rhythms (SWS and PS) flattened in amplitude. An immobilization stress (IS) of 1 h, imposed on AdX rats at t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bonnet C,Marinesco S,Debilly G,Kovalzon V,Cespuglio R

    更新日期:2000-01-24 00:00:00

  • Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats.

    abstract::Aging leads to a decrease in the number of neurons expressing vasopressin (VP) and vasoactive intestinal polypeptide (VIP) in the suprachiasmatic nucleus (SCN) of the rat. Similar results were observed following prolonged alcohol consumption and withdrawal. In the latter circumstances, the administration of nerve grow...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pereira PA,Cardoso A,Paula-Barbosa MM

    更新日期:2005-06-28 00:00:00

  • Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina.

    abstract::Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Daniels MP,Vogel Z

    更新日期:1980-11-10 00:00:00

  • Central amygdaloid nucleus lesion attenuates exaggerated hemodynamic responses to noise stress in the spontaneously hypertensive rat.

    abstract::The regional hemodynamic basis of the cardiovascular response to acute noise stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the role of the central amygdaloid nucleus in mediating this response was investigated. Using the pulsed Doppler flow probe technique it was determined that in respons...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Galeno TM,Van Hoesen GW,Brody MJ

    更新日期:1984-01-23 00:00:00

  • Auditory evoked M100 reflects onset acoustics of speech sounds.

    abstract::Magnetoencephalography (MEG) was used to investigate the response to speech sounds that differ in onset dynamics, parameterized as words that have initial stop consonants (e.g., /b/, /t/) or do not (e.g., /m/, /f/). Latency and amplitude of the M100 auditory evoked neuromagnetic field, recorded over right and left aud...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章


    authors: Gage N,Poeppel D,Roberts TP,Hickok G

    更新日期:1998-12-14 00:00:00

  • Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats.

    abstract::Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zettler C,Rush RA

    更新日期:1993-06-18 00:00:00

  • Differential expression of CPD1 during postnatal development in the mouse cerebellum.

    abstract::Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Radrizzani M,Vilá-Ortiz G,Cafferata EG,Di Tella MC,González-Guerrico A,Perandones C,Pivetta OH,Carminatti H,Idoyaga Vargas VP,Santa-Coloma TA

    更新日期:2001-07-13 00:00:00

  • Axonal transport in serotonin neurons of the midbrain raphe.

    abstract::The projections of serotonin-containing neurons of the midbrain raphe nuclei (nucleus raphe dorsalis, nucleus centralis superior) are studied by analysis of axonal transport of labeled amino acids. These results are correlated with regional alterations of serotonin content following midbrain raphe lesions which produc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Halaris AE,Jones BE,Moore RY

    更新日期:1976-05-14 00:00:00

  • Differential response of hippocampal and prefrontal oscillations to systemic LPS application.

    abstract::The early electrophysiological phenomena linked to systemic inflammation are largely underexplored. We developed here local field analyses to detect prodromal oscillatory abnormalities. We identified early band-specific patterns in local field potential recorded from freely-moving rats injected intraperitoneally with ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mamad O,Islam MN,Cunningham C,Tsanov M

    更新日期:2018-02-15 00:00:00

  • Serotonergic phase advances of the mammalian circadian clock involve protein kinase A and K+ channel opening.

    abstract::The mammalian circadian clock located in the suprachiasmatic nuclei (SCN) continues to oscillate when isolated in a brain slice preparation, and can be phase shifted in vitro by a variety of serotonergic (5-HTergic) agents. We have previously shown that 5-HT and a 5-HT agonist, quipazine, induce phase advances in the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Prosser RA,Heller HC,Miller JD

    更新日期:1994-04-25 00:00:00

  • Evidence for functional regeneration in the adult lamprey spinal cord following transection.

    abstract::We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cohen AH,Baker MT,Dobrov TA

    更新日期:1989-09-04 00:00:00