Abstract：
:GM1 ganglioside injections (i.p.) reduce amphetamine-induced asymmetric rotation in rats 48 h after a partial unilateral transection of the nigrostriatal pathway. We found that this reduction was maximal when rats received their first GM1 injection within 2 h after surgery. Rats injected 4-12 h after surgery, or rats only pretreated with GM1, showed no significant effect on rotation. Striatal membrane Na+,K+-ATPase in rats injected with GM1 0-2 h after hemitransection showed only a 10% loss in activity (versus the untransected hemisphere) as compared to control losses of 38%. The maintenance of membrane Na+,K+-ATPase activity in GM1-treated rats may be one mechanism by which a balance between hemispheres in striatal dopaminergic transmission is preserved, resulting in reduced asymmetric rotation. The observation that there is a critical postsurgical period when GM1 administration results in optimal functional recovery supports our hypothesis that gangliosides are exerting an acute effect on damaged CNS tissue. This acute effect is further evidenced by the reduced loss of membrane Na+,K+-ATPase following injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Li YS,Mahadik SP,Rapport MM,Karpiak SEdoi
10.1016/0006-8993(86)90871-1subject
Has Abstractpub_date
1986-07-09 00:00:00pages
292-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90871-1journal_volume
377pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01420-5
更新日期：1997-03-21 00:00:00
abstract：:Responses elicited by stimulating the pre-versus postganglionic nerves were compared in cat bladder parasympathetic neurons. We observed that synaptic potentials recorded on stimulating the postganglionic nerve trunk were different from those elicited with preganglionic nerve stimulation. These findings suggest that l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91634-9
更新日期：1987-12-01 00:00:00
abstract：:Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.053
更新日期：2016-10-01 00:00:00
abstract：:Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.02.049
更新日期：2016-10-15 00:00:00
abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90342-7
更新日期：1992-05-22 00:00:00
abstract：:Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90697-t
更新日期：1991-01-18 00:00:00
abstract：:Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91372-n
更新日期：1990-03-05 00:00:00
abstract：:In anaesthetized cats, effects of iontophoretic application of angiotensin II were studied in the nuclei of the tractus solitarius. Specifically, its effects were tested on single respiratory neurones, having rhythmic activity related temporally with the phrenic nerve discharge, and on presumed reflex interneurones, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91232-7
更新日期：1987-03-24 00:00:00
abstract：:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.006
更新日期：2013-08-02 00:00:00
abstract：:Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90693-h
更新日期：1993-02-05 00:00:00
abstract：:Results of previous studies suggested that incertohypothalamic dopamine (IHDA) neurons located in the medial zona incerta (MZI) project to the central nucleus of the amygdala (cAMY), horizontal diagonal band of Broca (HDB), and paraventricular nucleus (PVN). The overall goal of the present study was to determine the r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00809-9
更新日期：1998-10-19 00:00:00
abstract：:The effect of a dihydropyridine Ca2+ antagonist, cilnidipine, on voltage-dependent Ca2+ channels was studied in acutely dissociated rat CA1 pyramidal neurons using the nystatin-perforated patch recording configuration under voltage-clamp conditions. Cilnidipine had no effect on low-voltage-activated (LVA) Ca2+ channel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02295-7
更新日期：2000-01-31 00:00:00
abstract：:Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02399-9
更新日期：2000-02-28 00:00:00
abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00355-t
更新日期：1995-06-05 00:00:00
abstract：:The role of subcortical input and/or output pathways in the development of cortical networks was examined in organotypic tissue cultures derived from neonatal mouse brain. Comparisons were made between cultures of cerebral neocortex grown with large amounts of subcortical tissue and those that were completely isolated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91631-8
更新日期：1986-02-19 00:00:00
abstract：:Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats. The effect of intracerebroventricular (i.c.v.) administration of leptin on the nNOS mRNA level in the PVN and SON of fasting rats was studied by in situ hybridization his...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02065-x
更新日期：1999-11-06 00:00:00
abstract：:Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00404-6
更新日期：1997-07-18 00:00:00
abstract：:Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.04.035
更新日期：2016-07-01 00:00:00
abstract：:The regulation of corticotropin-releasing hormone (CRH) mRNA expression following maternal nutrient restriction was examined in the fetal hypothalamus. Pregnant guinea pigs were food restricted for 48 h or fed normally during late gestation. After nutrient restriction, CRH mRNA levels in the hypothalamic paraventricul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02089-3
更新日期：2001-03-30 00:00:00
abstract：:Reward deficit, expressed as anhedonia, is one of the major symptoms associated with neuropsychiatric disorders, but the underlying maladaptations have not been understood. Herein, we test the hypothesis that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) may participate in the process. The stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146595
更新日期：2020-02-01 00:00:00
abstract：:The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90773-0
更新日期：1986-08-06 00:00:00
abstract：:Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90054-8
更新日期：1976-09-03 00:00:00
abstract：:Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.085
更新日期：2009-05-19 00:00:00
abstract：:The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90239-2
更新日期：1987-12-15 00:00:00
abstract：:As an approach to understanding why central neurons fail to regenerate, we have studied the response to proximal axotomy of transcallosal neurons of the cerebral cortex of the mouse. Anatomical studies have indicated only very slight regenerative responses by this population of cortical neurons. To further examine the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00100-5
更新日期：1997-05-02 00:00:00
abstract：:Cerebral cortex membranes from rats habituated to manipulations preceding decapitation (habituated rats) had 40% higher GABA binding than membranes from naive animals. Diazepam (5 X 10(-6) M), added to membranes from naive rats, increased GABA binding to the level of habituated rats, but failed to induce any further i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91114-4
更新日期：1984-07-02 00:00:00
abstract：:Somatosensory information has been thought to ascend from the spinal cord to limbic areas of the telencephalon through indirect, multisynaptic pathways. We now report that injections of Fluoro-gold into either the nucleus accumbens or the septal nuclei labeled hundreds of neurons in the spinal cord. These and our rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90981-5
更新日期：1989-09-11 00:00:00
abstract：:The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90238-6
更新日期：1988-08-01 00:00:00
abstract：:Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.016
更新日期：2008-07-30 00:00:00
abstract：:An immunohistochemical investigation of the bovine pineal gland was performed using both a rabbit polyclonal antibody and a rat monoclonal antibody against choline acetyltransferase (ChAT). A network of ChAT-immunoreactive (IR) nerve fibers was located throughout the pineal gland, both in the perivascular spaces and b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91268-6
更新日期：1991-04-05 00:00:00
