Abstract：
:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions including Lewy bodies in Parkinson's disease, neurofibrillary tangles in Alzheimer's disease, polyQ inclusions in expansion repeat diseases and various proteinopathies associated with ALS and frontotemporal dementia. Using specific ubiquilin-2 antibodies and a series of transgenic mouse models of proteinopathies associated with neurodegenerative disease, we show that ubiquilin-2 preferentially associates with huntingtin polyQ expansion aggregates compared to α-synuclein, tau and several other types of protein inclusions. These results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions, but only infrequently in other types of protein inclusions. In cultured cells, ubiquilin-2 associates with huntingtin/polyQ aggregates, but this is not compromised by disease-causing mutations. Although ubiquilin proteins can function as chaperones to shuttle proteins for degradation, there is persistent co-localization between ubiquilin-2 and polyQ aggregated proteins during disease progression in the N586-82Q-C63 Huntington's disease mouse model. Thus, the co-localization of ubiquilin-2 with the huntingtin aggregates does not appear to facilitate aggregate removal.
journal_name
Brain Resjournal_title
Brain researchauthors
Rutherford NJ,Lewis J,Clippinger AK,Thomas MA,Adamson J,Cruz PE,Cannon A,Xu G,Golde TE,Shaw G,Borchelt DR,Giasson BIdoi
10.1016/j.brainres.2013.06.006subject
Has Abstractpub_date
2013-08-02 00:00:00pages
62-73eissn
0006-8993issn
1872-6240pii
S0006-8993(13)00836-6journal_volume
1524pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The 'commissural' innervation of the dentate gyrus molecular layer has been analyzed in normal adult rats and in those in which the ipsilateral entorhinal cortex had been removed by aspiration at 14 days post-natal. This ablation severely deafferents the distal two-thirds of the molecular layer and induces 'sprouting'...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90512-2
更新日期：1979-10-12 00:00:00
abstract：:Previous studies in piglets show that opioid-induced pial artery dilation was impaired following fluid percussion brain injury (FPI). This study was designed to determine the role of the newly described opioid nociceptin orphanin FQ (NOC/oFQ) in such impaired dilation to other opioids after FPI. CSF NOC/oFQ concentrat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02367-2
更新日期：2000-06-30 00:00:00
abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90021-0
更新日期：1987-04-01 00:00:00
abstract：:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.027
更新日期：2007-08-20 00:00:00
abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90244-7
更新日期：1987-09-08 00:00:00
abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90993-9
更新日期：1978-11-17 00:00:00
abstract：:The effects of two kinds of antibiotics, minocycline (MNC) and ampicillin (AB-PC), on human sleep were investigated on 19 healthy male students to test for a relationship between human sleep and protein synthesis. These drugs and placebos were capsulated identically in appearance and were given to the subjects using t...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/0006-8993(83)90101-4
更新日期：1983-12-12 00:00:00
abstract：:This research examined the electrophysiological, behavioral and neuroanatomical changes following an injection of kainic acid (KA) which destroyed most of the CA3 pyramidal cells in the hippocampus. For 5 days following the injection of KA, the evoked potential (EP) in the CA1 pyramidal cells produced by stimulation o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90677-2
更新日期：1984-10-29 00:00:00
abstract：:Systemic administration of nicotinic receptor (nAChR) agonists is antinociceptive in models of acute pain whereas their intrathecal (i. t.) administration has been reported to be antinociceptive, nociceptive or without effect. It has been hypothesized that the action induced is dependent upon the subtype and location ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02472-0
更新日期：2000-07-28 00:00:00
abstract：:Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90494-5
更新日期：1988-08-16 00:00:00
abstract：:Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91800-7
更新日期：1994-07-11 00:00:00
abstract：:Vestibular nerve branches innervating the sensory epithelia of the three semicircular canals or of the three otolith organs of frogs were selectively labeled in-vitro with biocytin. Labeled afferent fibers from the semicircular canals, utricle, and lagena were encountered in each of the four vestibular nuclei and thei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03075-x
更新日期：2001-12-07 00:00:00
abstract：:Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1980-11-24 00:00:00
abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:After the microinjection of morphine (5 micrograms/0.5 microliter) into the periaqueductal gray resulted in an increase in the hot-plate and tail-flick response latency of the unanesthetized rat, the alpha-adrenergic antagonists yohimbine, rauwolscine and corynanthine were given intrathecally. This treatment resulted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90424-x
更新日期：1985-06-10 00:00:00
abstract：:This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91192-2
更新日期：1984-11-19 00:00:00
abstract：:Antibodies were raised in rabbits against the neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) coupled to bovine serum albumin via a carbodiimide linkage. One of these rabbit antisera, which preferentially recognizes coupled NAAG-like immunoreactivity (LIR), has been previously used to immunocytochemically localize...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90045-9
更新日期：1988-06-01 00:00:00
abstract：:The ventral tegmental area is a site of action by psychostimulants in the production of behavioral sensitization. Recently, G proteins of the ventral tegmental area have been implicated in behavioral sensitization to cocaine. To further investigate the specific role of G proteins, rats were treated with either 15 or 3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90049-f
更新日期：1992-05-08 00:00:00
abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01461-3
更新日期：1998-03-09 00:00:00
abstract：:Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90307-x
更新日期：1984-12-10 00:00:00
abstract：:Transependymal absorption of cerebrospinal fluid (CSF) in hydrocephalus is suggested by periventricular edema, but the necessary bulk flow of interstitial fluid (ISF) has not been found. We performed ventriculocisternal perfusions in adult cats using CSF with the extracellular marker [3H]sucrose. CSF pressure was main...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90616-3
更新日期：1982-01-28 00:00:00
abstract：:Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against isch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.060
更新日期：2009-09-29 00:00:00
abstract：:Recently developed antisera selective for angiotensin Type 2 (AT2) receptors were used to localize AT2 receptors in rat brain by immunohistochemistry. While the results from these experiments were largely consistent with previous autoradiographic and radioligand binding analyses of AT2 receptor populations in brain, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90794-3
更新日期：1994-10-31 00:00:00
abstract：:In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02890-0
更新日期：2000-11-10 00:00:00
abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
abstract：:Evidence from a number of sources indicates that the major site of pro-opiomelanocortin (POMC)-producing cells in the CNS is the arcuate nucleus of the hypothalamus. Using immunocytochemical techniques, a second, smaller group of POMC cells has been detected in the nucleus tractus solitarius (NTS) area of the caudal m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91007-2
更新日期：1992-08-07 00:00:00
abstract：:The distribution of S-100-immunoreactive material was examined in the central nervous system of the gastropod snail. Helix pomatia, and electrophysiological properties of S-100-positive neurons were characterized. Immunocytochemical studies revealed S-100-like protein to be present in neurons localized in the cerebral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01584-1
更新日期：1996-04-15 00:00:00
abstract：:The current experiment aimed to explore age differences in brain activity associated with successful memory retrieval in older adults with different levels of executive functioning, at different levels of task demand. Memory performance and fMRI activity during a recognition task were compared between a young group an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.009
更新日期：2016-01-15 00:00:00
abstract：:Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Studies reported in this paper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90552-9
更新日期：1985-03-11 00:00:00
abstract：:Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.035
更新日期：2014-06-20 00:00:00
