当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Spinal mechanisms underlying A-85380-induced effects on acute thermal pain.

Spinal mechanisms underlying A-85380-induced effects on acute thermal pain.

Abstract：

:Systemic administration of nicotinic receptor (nAChR) agonists is antinociceptive in models of acute pain whereas their intrathecal (i. t.) administration has been reported to be antinociceptive, nociceptive or without effect. It has been hypothesized that the action induced is dependent upon the subtype and location of the nAChR activated. In addition, there is considerable evidence that nAChR ligand-induced antinociception is mediated by other neurotransmitter systems via descending pathways from the brainstem to the spinal cord. The present study investigated the effects of i. t. and systemic administration of A-85380, a novel nAChR agonist, in the paw withdrawal model of acute thermal pain in the rat. Given i.t. , A-85380 (1 and 10 nmol/rat) decreased the latency to paw withdrawal by 2-4 s. This pronociception was accompanied by a spontaneous flinching behavior. Both of these effects were differentially blocked by i.t. pretreatment with the nAChR antagonists mecamylamine (10 nmol)>MLA (100 nmol)>DHbetaE (50% with 1000 nmol) but not by alpha-bungarotoxin (0% at 0.63 nmol). Given systemically, A-85380 (0.56 micromol/kg, i.p.) induced antinociception as indicated by an increased latency to paw withdrawal, an effect differentially altered by i.t. pretreatment with monoaminergic antagonists (100 nmol/rat). While mecamylamine and prazosin had no effect, scopolamine, methysergide and MDL 72222 partially antagonized and idazoxan completely antagonized A-85380-induced antinociception. Finally, as measured by in vivo microdialysis, levels of 5-HT, but not NE, in the i.t. space of the lumber region of the spinal cord were significantly increased following the systemic administration of A-85380. Together these data suggest that the nociceptive properties of spinally administered nAChR agents are not mediated by either an alpha(4)beta(2) or an alpha(7) subtype nAChR, whereas the antinociceptive properties of systemically-administered nAChR agents are mediated by descending noradrenergic, serotonergic and muscarinic inhibitory pathways.

journal_name

Brain Res

journal_title

Brain research

authors

Rueter LE,Meyer MD,Decker MW

doi

10.1016/s0006-8993(00)02472-0

subject

Has Abstract

pub_date

2000-07-28 00:00:00

pages

93-101

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(00)02472-0

journal_volume

872

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Sites of aromatization of [3H]testosterone in forebrain of male, female and androgen receptor-deficient Tfm mice: an autoradiographic study.

    abstract：:The distribution of radioactivity after injection of [3H]testosterone was studied in the forebrain of adult mice by thaw-mount autoradiography. Nuclear labeling was high in neurons in the dorsal part of the medial nucleus of the amygdala and in the dorsocaudal part of the bed nucleus of the stria terminalis. Low nucle...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90630-x

    authors： Schleicher G,Stumpf WE,Morin JK,Drews U

    更新日期：1986-11-12 00:00:00

  • Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

    abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)01488-8

    authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

    更新日期：1996-03-25 00:00:00

  • Musical scale properties are automatically processed in the human auditory cortex.

    abstract：:While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.08.023

    authors： Brattico E,Tervaniemi M,Näätänen R,Peretz I

    更新日期：2006-10-30 00:00:00

  • Postural change and straining induced by distension of the rectum, vagina and urinary bladder of decerebrate dogs.

    abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90223-4

    authors： Fukuda H,Fukai K

    更新日期：1986-08-20 00:00:00

  • The effect of acidosis on adenosine release from cultured rat forebrain neurons.

    abstract：:During cerebral ischemia, dysregulated glutamate release activates N-methyl-d-aspartate (NMDA) receptors which promotes excitotoxicity and intracellular acidosis. Ischemia also induces cellular adenosine (ADO) release, which activates ADO receptors and reduces neuronal injury. The aim of this research was to determine...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.01.115

    authors： Zamzow CR,Bose R,Parkinson FE

    更新日期：2006-04-12 00:00:00

  • Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead.

    abstract：:The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2011.11.062

    authors： Baranowska-Bosiacka I,Gutowska I,Marchlewicz M,Marchetti C,Kurzawski M,Dziedziejko V,Kolasa A,Olszewska M,Rybicka M,Safranow K,Nowacki P,Wiszniewska B,Chlubek D

    更新日期：2012-01-30 00:00:00

  • Catecholamine effects on dissociated tiger salamander Muller (glial) cells.

    abstract：:Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90081-j

    authors： Henshel DS,Miller RF

    更新日期：1992-03-20 00:00:00

  • Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats.

    abstract：:Vascular dysfunction is important in the pathogenesis of peripheral complications of diabetes. However, the effects of diabetes on cerebral blood flow and the role of vascular deficits in the pathogenesis of diabetic encephalopathy are still unknown. The present study examined whether experimental diabetes is associat...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)04211-7

    authors： Manschot SM,Biessels GJ,Cameron NE,Cotter MA,Kamal A,Kappelle LJ,Gispen WH

    更新日期：2003-03-21 00:00:00

  • Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive.

    abstract：:To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. R...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00194-2

    authors： Kang W,Wilson MA,Bender MA,Glorioso JC,Wilson SP

    更新日期：1998-05-04 00:00:00

  • The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing.

    abstract：:This study examined whether baseline PPI levels reflect individual efficiency in tasks associated with routine versus supervisory attentional systems (SAS). PPI and neuropsychological data were collected from 30 healthy male subjects. High PPI was associated with shorter movement times on the 5-choice Reaction Time an...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.01.056

    authors： Giakoumaki SG,Bitsios P,Frangou S

    更新日期：2006-03-17 00:00:00

  • Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP.

    abstract：:Tyrosine hydroxylase immunohistochemical examination of the mesencephalon of severely parkinsonian MPTP-treated macaque fascicularis monkeys revealed a marked loss of substantia nigra pars compacta (SNc) neurons in both medial and central portions of the nucleus with a relative sparing of neurons in the dorsal-most po...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90691-3

    authors： Schneider JS,Yuwiler A,Markham CH

    更新日期：1987-05-12 00:00:00

  • Upregulation of the brainstem preproglucagon system in the obese Zucker rat.

    abstract：:A group of neurons in the caudal nucleus of the solitary tract (NTS) processes preproglucagon to glucagon-like peptide 1 (GLP-1), GLP-2 and oxyntomodulin. Whereas the anorectic capacity of all three neuropeptides has been demonstrated, only relatively little is known of preproglucagon mRNA regulation in the brain stem...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.10.026

    authors： Vrang N,Larsen PJ,Jensen PB,Lykkegaard K,Artmann A,Larsen LK,Tang-Christensen M

    更新日期：2008-01-02 00:00:00

  • Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable spreading depression induced by microdialysis of elevated K+ in hippocampus of anesthetized rats.

    abstract：:The potential shifts (delta Vo) associated with spreading depression (SD) were analysed with the help of multiple extracellular recording and ion-selective microelectrodes in the CA1 region of the dorsal hippocampus of anesthetized rats. Recurrent waves of SD were induced by perfusing high K+ solution through microdia...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91412-l

    authors： Herreras O,Somjen GG

    更新日期：1993-05-07 00:00:00

  • Relationship between large conductance calcium-activated potassium channel and bursting activity.

    abstract：:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)01943-0

    authors： Jin W,Sugaya A,Tsuda T,Ohguchi H,Sugaya E

    更新日期：2000-03-31 00:00:00

  • Relative effects of mannitol and hypertonic saline on calpain activity, apoptosis and polymorphonuclear infiltration in traumatic focal brain injury.

    abstract：:The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.05.045

    authors： Soustiel JF,Vlodavsky E,Zaaroor M

    更新日期：2006-07-26 00:00:00

  • Regeneration of primary afferent neurons containing substance P-like immunoreactivity.

    abstract：:We compared changes in levels of substance P-like immunoreactivity (SPLI) in L4-6 dorsal root ganglia (DRG), L4-6 dorsal roots, sciatic nerve, tibial nerve and hind foot skin in rats following resection or crush injury of the sciatic nerve. The initial depletion of SPLI, which occurred in all areas sampled, was simila...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90725-0

    authors： Bisby MA,Keen P

    更新日期：1986-02-12 00:00:00

  • Audiogenic seizures evoked in DBA/2 mice induce c-fos oncogene expression into subcortical auditory nuclei.

    abstract：:Recently the nuclear proto-oncogene c-fos has been shown to be rapidly and transiently expressed following seizures in many types of epilepsies. Until now, immunohistochemical as well as in situ hybridization studies have reported that the dentate gyrus of the hippocampus and most of the cortical areas were invariably...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90988-n

    authors： Le Gal La Salle G,Naquet R

    更新日期：1990-06-04 00:00:00

  • Contribution of fat metabolism to 'glucoprivic' feeding produced by fourth ventricular 5-thio-D-glucose.

    abstract：:We examined whether manipulations of fat metabolism influence the feeding response to peripheral or central administration of 5-thio-D-glucose (5-TG), a potent inhibitor of glucose utilization. The increase in food intake produced by peritoneal (50 mg/kg) or fourth ventricular (50, 100, 150 micrograms) 5-TG was potent...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)91181-x

    authors： Tordoff MG,Flynn FW,Grill HJ,Friedman MI

    更新日期：1988-04-05 00:00:00

  • Decreases in excitatory synaptic transmission and increases in recurrent inhibition in the rat dentate gyrus after transient cerebral ischemia.

    abstract：:Excitatory transmission along the perforant path from the entorhinal cortex to the granule cells of the dentate gyrus was evaluated two days after 10 min of transient cerebral ischemia in the rat. The amplitude of the population spike, and the amplitude and the initial slope of the population excitatory postsynaptic p...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)91446-7

    authors： Chang HS,Steward O,Kassell NF

    更新日期：1989-12-29 00:00:00

  • Relative sparing of primary auditory cortex in Williams Syndrome.

    abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.11.038

    authors： Holinger DP,Bellugi U,Mills DL,Korenberg JR,Reiss AL,Sherman GF,Galaburda AM

    更新日期：2005-03-10 00:00:00

  • Recovery of choline acetyltransferase and acetylcholinesterase activities in the ipsilateral hippocampus following unilateral, partial transection of the fimbria in rats.

    abstract：:An initial decrement followed by a significant recovery of choline acetyltransferase and acetylcholinesterase activities in the ipsilateral hippocampus was observed in rats with unilateral, partial transection of the fimbria. Regeneration of hippocampal cholinergic terminals could account for the parallel return towar...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)90921-6

    authors： Dravid AR,van Deusen EB

    更新日期：1983-10-24 00:00:00

  • Effect of steroid competition and time on the uptake of (3H)corticosterone in the rat brain; an autoradiographic study.

    abstract：:The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(75)90937-3

    authors： Rhees RW,Grosser BI,Stevens W

    更新日期：1975-01-10 00:00:00

  • Dynamic changes of brain networks during feedback-related processing of reinforcement learning in schizophrenia.

    abstract：:Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2020.146979

    authors： Zhao Z,Wang C,Yuan Q,Zhao J,Ren Q,Xu Y,Li J,Yu Y

    更新日期：2020-11-01 00:00:00

  • Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum.

    abstract：:Based on electrophysiological data showing that repeated cocaine administration produces persistent enhancement of D1 dopamine (DA) receptor-mediated responses in nucleus accumbens (NAc), we investigated whether changes in neurochemical properties of these receptors resulted when rats were injected with cocaine (15 mg...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90783-6

    authors： Mayfield RD,Larson G,Zahniser NR

    更新日期：1992-02-28 00:00:00

  • Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax.

    abstract：:Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.01.080

    authors： Sharma K,Mehra RD

    更新日期：2008-04-14 00:00:00

  • Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings.

    abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.03.064

    authors： Dunn JP,Cowan RL,Volkow ND,Feurer ID,Li R,Williams DB,Kessler RM,Abumrad NN

    更新日期：2010-09-02 00:00:00

  • The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization.

    abstract：:Serotonin 1A (5HT1A) receptor agonists have shown neuroprotective properties in different models of central nervous system injury. Activation of neuronal 5HT1A receptors appears to be involved in the neuroprotective effects. It remains to be elucidated if astroglial cells are responsive to the 5HT1A neuroprotective ef...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.10.019

    authors： Ramos AJ,Rubio MD,Defagot C,Hischberg L,Villar MJ,Brusco A

    更新日期：2004-12-31 00:00:00

  • Opening the blood-brain barrier to zinc.

    abstract：:Sheep with guide tubes implanted over the brain lateral ventricles, in order to facilitate episodic sampling of cerebrospinal fluid (CSF), were used to determine the effects of increasing cranial blood osmolality or electroconvulsive shock (ECS) on the permeability of the blood-brain barrier (BBB) to zinc. Zinc acetat...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90513-b

    authors： Blair-West JR,Denton DA,Gibson AP,McKinley MJ

    更新日期：1990-01-15 00:00:00

  • Changes in the activity of testosterone-metabolizing enzymes in the brain of male and female zebra finches during the post-hatching period.

    abstract：:The kinetic properties of the testosterone-metabolizing enzymes were studied in the hypothalamus of adult and young zebra finches of both sexes. Estradiol, 5 alpha-dihydrotestosterone, 5 beta-dihydrotestosterone and 5 beta-androstane-3 alpha,17 beta-diol were identified as metabolites of testosterone in males and fema...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)90406-4

    authors： Vockel A,Pröve E,Balthazart J

    更新日期：1988-11-01 00:00:00

  • Distribution of histaminergic, muscarinic and serotonergic binding sites in cat spinal cord with emphasis on the region surrounding the central canal.

    abstract：:[3H]Quinuclidinyl benzilate (QNB), [3H]lysergic acid diethylamide (LSD) and [3H]pyrilamine were used with radiohistochemistry to determine the distribution of muscarinic, serotonergic and histaminergic binding sites, respectively, in cat spinal cord. Each ligand displayed a unique pattern of binding sites in the super...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)91128-x

    authors： Seybold VS

    更新日期：1985-09-09 00:00:00