Abstract：
:[3H]Quinuclidinyl benzilate (QNB), [3H]lysergic acid diethylamide (LSD) and [3H]pyrilamine were used with radiohistochemistry to determine the distribution of muscarinic, serotonergic and histaminergic binding sites, respectively, in cat spinal cord. Each ligand displayed a unique pattern of binding sites in the superficial laminae of the dorsal horn [3H]Pyrilamine binding sites were localized most superficially, while [3H]LSD binding sites were densest in the region of the laminae II/III border. The distribution of [3H]QNB binding sites partially overlapped those of LSD and pyrilamine. In the region surrounding the central canal, pyrilamine binding sites were concentrated within a zone 100 microns lateral to the canal while [3H]QNB and [3H]LSD binding sites were localized outside of this zone. The distribution of binding sites in the region surrounding the central canal may provide an important neurochemical correlate for lamina X in the cat as defined by Rexed.
journal_name
Brain Resjournal_title
Brain researchauthors
Seybold VSdoi
10.1016/0006-8993(85)91128-xsubject
Has Abstractpub_date
1985-09-09 00:00:00pages
291-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91128-Xjournal_volume
342pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion channel block between cells, suggesting differential expressi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00007-9
更新日期：1998-04-13 00:00:00
abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.066
更新日期：2008-03-04 00:00:00
abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90864-9
更新日期：1985-11-04 00:00:00
abstract：:Anandamide, the ethanolamide of arachidonic acid, is an endogenous cannabinoid. It is an agonist at CB1 and CB2 cannabinoid receptors as well as the vanilloid receptor, VR1. It is analgesic in inflammatory and neuropathic pain. Both central and peripheral mechanisms are considered to participate in its analgesia. Prim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.004
更新日期：2005-11-16 00:00:00
abstract：:The relationship between changes in regional brain bioamine levels and the expression of intraspecies aggressive behavior was evaluated in two murine models. In one study, normal male mice were maintained either in aggregate (i.e., normal, intraspecies social behavioral controls) or isolated (i.e., developed, non-soci...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03963-x
更新日期：2003-02-14 00:00:00
abstract：:The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17 beta-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91057-2
更新日期：1987-01-27 00:00:00
abstract：:Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.045
更新日期：2011-08-17 00:00:00
abstract：:The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90017-5
更新日期：1994-04-18 00:00:00
abstract：:The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91597-0
更新日期：1994-08-29 00:00:00
abstract：:The glutamate terminals in rat rostral neostriatum were removed on one side by ipsilateral frontal cortical ablation. Intraperitoneal administration of L-methioninesulfoximine (MSO), an inhibitor of glutamine synthetase, induced different changes in amino acid concentration in the rostral neostriatum on the intact and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90261-6
更新日期：1985-07-08 00:00:00
abstract：:Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no signif...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90949-6
更新日期：1983-10-31 00:00:00
abstract：:Projections from the hypothalamus to cells of origin of the greater petrosal nerve were studied by the HRP and autoradiographic techniques in the rat. After an injection of [3H]amino acids into the hypothalamus and an application of HRP to the greater petrosal nerve, we found that a compact group of HRP-labeled neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90744-3
更新日期：1984-01-02 00:00:00
abstract：:Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90007-4
更新日期：1975-11-14 00:00:00
abstract：:A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it is proposed that a hyper-responsi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.038
更新日期：2015-12-10 00:00:00
abstract：:The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90002-4
更新日期：1989-06-05 00:00:00
abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.017
更新日期：2005-02-28 00:00:00
abstract：:Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91651-9
更新日期：1994-05-09 00:00:00
abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.07.026
更新日期：2016-05-01 00:00:00
abstract：:We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90937-5
更新日期：1984-08-06 00:00:00
abstract：:Axonal and glial cell development within rat optic nerve in which gliogenesis was altered by systemic injection of 5-azacytidine (5-AZ) was examined by quantitative electron microscopy. In neonatal (0-2 days) rat optic nerves, all fibers are premyelinated, and they exhibit a fairly uniform diameter (approximately 0.22...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91436-8
更新日期：1986-08-13 00:00:00
abstract：:Affective disorders and memory impairments precede the classical motor symptoms seen in Parkinson's disease (PD) and the currently approved antiparkinsonian agents do not alleviate the non-motor symptoms as well as the underlying dopaminergic neuron degeneration. On the other hand, there is increasing evidence that in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.029
更新日期：2013-06-04 00:00:00
abstract：:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90137-7
更新日期：1982-07-01 00:00:00
abstract：:Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00404-6
更新日期：1997-07-18 00:00:00
abstract：:The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum (monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovarie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90632-w
更新日期：1993-07-16 00:00:00
abstract：:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.109
更新日期：2006-08-23 00:00:00
abstract：:Glycogen synthase kinase (GSK)-3beta and extracellular signal-regulated kinase (ERK) regulate several cellular signaling pathways in common, including embryonic development, cell differentiation and apoptosis. In this study, we investigated whether GSK-3beta inhibition is involved in ERK activation, which affects the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.018
更新日期：2007-12-01 00:00:00
abstract：:Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91061-5
更新日期：1991-03-08 00:00:00
abstract：:We identified cell bodies of a pair of the cardio-inhibitory (CI) neurons in the first thoracic ganglion (TG1) of Bathynomus doederleini. Each of the cell bodies gives rise to a single axon, which runs into the contralateral hemiganglion of TG1 via the commissure and runs to the heart via the fourth root as CI axon. S...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90789-x
更新日期：1991-09-06 00:00:00
abstract：:Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were fou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90360-7
更新日期：1976-10-22 00:00:00
abstract：:Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.063
更新日期：2015-07-01 00:00:00
