Abstract：
:Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was found that the first appearance of a positive HRP reaction coincided with the time when nerve processes are first detected in the limb-bud by silver techniques (i.e. at 4.5 days of incubation). Only neurons with processes in the region of injection showed a positive reaction. The demonstration of a retrograde transport mechanism in neurons and axons which are still undergoing growth and differentiation provides a possible mechanism for the peripheral regulation of certain features of CNS neurogenesis. The application of this technique during development may also allow one to map neuroanatomical pathways during their formation.
journal_name
Brain Resjournal_title
Brain researchauthors
Oppenheim RW,Heaton MBdoi
10.1016/0006-8993(75)90007-4subject
Has Abstractpub_date
1975-11-14 00:00:00pages
291-302issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(75)90007-4journal_volume
98pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Extracellular levels of acetylcholine (ACh) were measured in the central nucleus of the amygdala using microdialysis in 20-min intervals before, during, and after 1 h feeding in food-deprived rats. The results were compared to the effects of peripheral injections of glucose or 'low' (200 mU) and 'high' (1 U) doses of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01291-2
更新日期：1998-02-23 00:00:00
abstract：:Humans rely on the integration of information from multiple sensory modalities to interact successfully with their environment. In the present series of studies, we investigated how the visuomotor system integrates congruent and incongruent visual and tactile sensory inputs for goal-directed action comprehension and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.081
更新日期：2008-11-25 00:00:00
abstract：:The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91436-5
更新日期：1991-12-13 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02585-x
更新日期：2003-06-27 00:00:00
abstract：:Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also been used to ide...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.030
更新日期：2009-02-27 00:00:00
abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90142-x
更新日期：1990-11-26 00:00:00
abstract：:CNS inflammation is a sequela of a variety of neuropathological conditions resulting in extensive tissue loss. Inflammation is mediated primarily by phagocytic cells, but the mechanisms of CNS tissue destruction are not fully understood. Hypochlorous acid (HOCl) is by far the most abundant agent generated by phagocyti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.080
更新日期：2004-02-06 00:00:00
abstract：:Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90308-1
更新日期：1984-12-10 00:00:00
abstract：:A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91100-7
更新日期：1993-07-23 00:00:00
abstract：:Female rats were subjected to unilateral left or right, bilateral, or sham ablation of the cerebral cortex. Eight weeks after surgery, the rats were sacrificed by decapitation and spleen cells were grown in culture for 96 h in the presence or absence of the T-cell mitogen concanavalin A or the B-cell mitogen lipopolys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90042-5
更新日期：1989-03-27 00:00:00
abstract：:The so-called on- and off-cells of the rostral ventromedial medulla (RVM) send their axons to the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and activation of off-cells coincides with an inhibition, of withdrawal reflexes elicited by noxious agents. Considerable evidence sup...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.02.025
更新日期：2018-05-01 00:00:00
abstract：:Tyrosine kinase B (TrkB) levels in the adult guinea pig cochlear nucleus (CN) were determined from Western blots for up to 60 days after unilateral cochlear ablation (UCA). Compared to TrkB levels on the intact side, those on the lesioned side were elevated in the anteroventral CN (AVCN) at 7 and 60 days and in the po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03679-x
更新日期：2002-12-13 00:00:00
abstract：:We investigated the effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) on cytosolic free calcium ([Ca2+]i) at a single cell level in both type-1 and type-2 cultured rat astrocytes using a calcium-sensitive fluorescent dye, fura-2. Type-1 astrocytes were relatively silent during the 20 min observat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90790-0
更新日期：1994-10-31 00:00:00
abstract：:The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. This circadian rhythm was blunted significantly during the infusion of clonidine. The fall in body temperat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91088-7
更新日期：1986-10-22 00:00:00
abstract：:The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90706-3
更新日期：1989-05-29 00:00:00
abstract：:The time course of the variations in tyrosine hydroxylase (TH) activity was measured in the rat locus coeruleus (LC) after lesions of the nucleus raphe dorsalis (NRD), nucleus raphe centralis superior (NRCS) and nucleus raphe pontis (NRP). A certain number of lesions were performed in the raphe magnus (RM), the caudal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91008-3
更新日期：1982-03-11 00:00:00
abstract：:To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the correct ratio of lon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02084-4
更新日期：2001-03-23 00:00:00
abstract：:Paranodal glial loops (lateral belt cytoplasm) of myelinated CNS and PNS fibres contain tubules of agranular reticulum, as well as microtubules, wound spirally around the axon. Similar agranular elements run circumferentially in the expanded rims of sheet-like astrocytic processes encapsulating thalamic synaptic glome...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90414-x
更新日期：1980-09-08 00:00:00
abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91311-n
更新日期：1991-04-05 00:00:00
abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90174-4
更新日期：1986-01-01 00:00:00
abstract：:Several lines of evidence support a role for nerve growth factor (NGF) in the sympathetic sprouting response that occurs following septal cholinergic denervation of the rat hippocampal formation. The present study was undertaken to compare the distribution of NGF-like immunoreactivity and the topography of sympathetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01344-h
更新日期：1995-02-20 00:00:00
abstract：:A hemodynamic mechanism has long been assumed to play an important role in watershed infarction. In recent years, however, clinical evidence has indicated that an embolic mechanism is involved. The mechanism by which emboli are trapped preferentially in watershed areas remains unclear. In the present study, we develop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.11.028
更新日期：2018-01-15 00:00:00
abstract：:Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00940-r
更新日期：1995-11-27 00:00:00
abstract：:The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90884-3
更新日期：1978-08-04 00:00:00
abstract：:A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged, normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynapti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90836-2
更新日期：1981-11-30 00:00:00
abstract：:Glutamate carboxypeptidase II may modulate excitatory neurotransmission through the catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) and possibly other endogenous peptide substrates. To investigate the molecular properties of cloned human GCP II (hGCP II), we analyzed the NAAG-hydrolytic activity convey...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00244-3
更新日期：1998-06-08 00:00:00
abstract：:The effects of injecting cholecystokinin (CCK) into the third ventricle or into selected hypothalamic sites on electrical firing rate of sympathetic nerves to interscapular brown fat (IBAT) has been investigated in anesthetized rats. The hypothesis for these experiments was that there was a reciprocal relationship bet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91486-x
更新日期：1992-12-04 00:00:00
abstract：:Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition change...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2010.05.062
更新日期：2010-09-02 00:00:00
abstract：:Murine spinal cord primary mixed cultures were treated with the respiratory inhibitor, rotenone, to mimic hypoxic conditions. Under these conditions neurons rapidly underwent oncosis (necrosis) with a complete loss in viability occurring within 260 min; however, astrocytes, which accounted for most of the cell populat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01086-0
更新日期：1999-03-13 00:00:00
abstract：:The postnasal development of the Na-independent [3H]glutamate binding sites, which exhibit some characteristics of postsynaptic glutamate receptors, has been studied in rat hippocampal membranes. The amount of binding sites (expressed in pmol/hippocampus) represents 4% of the adult level at postnatal day (PND) 4, incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90092-4
更新日期：1981-01-01 00:00:00
