Glycine cleavage system in astrocytes.

Abstract:

:The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest staining being noted in the hippocampus, the cerebellar cortex, the Bergmann glia in the cerebellum and the Muller cells in the retina. The weakest staining was seen in the brainstem and spinal cord. P-protein was found to be located in the mitochondria by an ultrastructual study.

journal_name

Brain Res

journal_title

Brain research

authors

Sato K,Yoshida S,Fujiwara K,Tada K,Tohyama M

doi

10.1016/0006-8993(91)91436-5

subject

Has Abstract

pub_date

1991-12-13 00:00:00

pages

64-70

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91436-5

journal_volume

567

pub_type

杂志文章
  • Motor function and dopamine release measurements in transgenic Huntington's disease model rats.

    abstract::Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.02.042

    authors: Ortiz AN,Osterhaus GL,Lauderdale K,Mahoney L,Fowler SC,von Hörsten S,Riess O,Johnson MA

    更新日期:2012-04-23 00:00:00

  • The Vps33a gene regulates behavior and cerebellar Purkinje cell number.

    abstract::A mutation in the Vps33a gene causes Hermansky-Pudlak Syndrome (HPS)-like-symptoms in the buff (bf) mouse mutant. The encoded product, Vps33a, is a member of the Sec1 and Class C multi-protein complex that regulates vesicle trafficking to specialized lysosome-related organelles. As Sec1 signaling pathways have been im...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.02.035

    authors: Chintala S,Novak EK,Spernyak JA,Mazurchuk R,Torres G,Patel S,Busch K,Meeder BA,Horowitz JM,Vaughan MM,Swank RT

    更新日期:2009-04-17 00:00:00

  • Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice.

    abstract::Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on the environmental temperature. Here, we evaluate whether a cold environment (4 degrees C) or drugs which chloride and glutamate ion channel function block METH neurotoxicity in mice. Adult male CD mice received METH i.p. (4 x 10 mg/...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(09)90007-5

    authors: Ali SF,Newport GD,Holson RR,Slikker W Jr,Bowyer JF

    更新日期:1994-09-26 00:00:00

  • Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model.

    abstract::Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.10.089

    authors: Kang JM,Park HJ,Choi YG,Choe IH,Park JH,Kim YS,Lim S

    更新日期:2007-02-02 00:00:00

  • Brain damage in a mouse model of global cerebral ischemia. Effect of NMDA receptor blockade.

    abstract::The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)03014-2

    authors: Olsson T,Wieloch T,Smith ML

    更新日期:2003-08-29 00:00:00

  • The effects of pattern shape, subliminal stimulation, and voluntary control on multistable visual perception.

    abstract::Spontaneous figure reversal of ambiguous patterns was analyzed in humans. A) With Necker-"cube"-like, or "drum"-like figures, having square or round shaped "front" and "rear" surfaces, and either large or small "depth", the perceptual intervals corresponding to both interpretations of "drum" were longer than those of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.04.064

    authors: Taddei-Ferretti C,Radilova J,Musio C,Santillo S,Cibelli E,Cotugno A,Radil T

    更新日期:2008-08-15 00:00:00

  • Activity of identified cortically projecting and other basal forebrain neurones during large slow waves and cortical activation in anaesthetized rats.

    abstract::To examine the role played by the basal forebrain cholinergic system in cortical activation, neuronal activity was investigated in the globus pallidus and substantia innominata of urethane-anaesthetized rats during large cortical slow waves and spontaneous or elicited low voltage fast activity. An effort was made to i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91521-6

    authors: Détári L,Vanderwolf CH

    更新日期:1987-12-22 00:00:00

  • Trajectory of contralateral entorhinal axons which reinnervate the fascia dentata of the rat following ipsilateral entorhinal lesions.

    abstract::Unilateral destruction of the entorhinal area in the rat results in the proliferation of a pathway from the surviving contralateral entorhinal area to the fascia dentata denervated by the lesions (the crossed temporodentate pathway). The present study analyzes the point of entry of these reinnervating fibers into the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90464-3

    authors: Steward O

    更新日期:1980-02-10 00:00:00

  • Estrogen-dependent post-translational change in the nitric oxide system may mediate the leptin action on LH and prolactin secretion.

    abstract::Gonadotrophin-releasing hormone (GnRH) neurons do not express the leptin receptor (OB-R) in the medial preoptic area (MPOA) and the medial basal hypothalamus (MBH). We assessed whether the effect of leptin on the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) in proestrus...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.02.001

    authors: Del Bianco-Borges B,Franci CR

    更新日期:2015-04-16 00:00:00

  • Cerebrospinal fluid (CSF) and brain monoamine metabolites in the developing rat pup.

    abstract::Concentrations of the neurotransmitters, serotonin (5-HT), dopamine (DA), and norepinephrine (NE) were measured in the developing rat brain at 12, 19, 26 and 42 days of age. The amino acid precursors, tryptophan (TRP) and tyrosine (TYR) were measured along with the 5-HT and DA metabolites, 5-hydroxyindoleacetic acid (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90146-4

    authors: Shaywitz BA,Anderson GM,Cohen DJ

    更新日期:1985-01-01 00:00:00

  • What can development teach us about menopause?

    abstract::Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by ...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2010.11.094

    authors: McCarthy MM

    更新日期:2011-03-16 00:00:00

  • The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat.

    abstract::The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91244-b

    authors: Vera PL,Nadelhaft I

    更新日期:1990-09-03 00:00:00

  • The distribution and central termination of single cutaneous and muscle unmyelinated fibres in rat spinal cord.

    abstract::An electrophysiological approach has been used to trace the central course of individual C fibres from a cutaneous (sural) and muscle (gastrocnemius) nerve in anaesthetized rats. Single C fibres were recorded from the central part of cut peripheral nerves and a glass micropipette used to map the spinal cord with low t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91410-6

    authors: McMahon SB,Wall PD

    更新日期:1985-12-16 00:00:00

  • Activity of prolidase isoenzymes in the rat brain: subcellular and regional distribution during development.

    abstract::Prolidase deficiency is characterized by chronic ulcerative dermatitis, mental retardation, and frequent infections. In the present study we examined the characteristics of rat brain prolidase isoenzymes. Prolidase isoenzymes (PD I and PD II) were isolated from the rat brain using DEAE cellulose column chromatography....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.09.081

    authors: Chi H,Lu J,Liu G,Tong J,Nakayama K,Yamashita K,Kitaoka N,Kodama H

    更新日期:2009-12-15 00:00:00

  • Convergence of subthalamic and striatal efferents at pallidal level in primates: an anterograde double-labeling study with biocytin and PHA-L.

    abstract::Small injections of two highly sensitive anterograde tracers, Phaseolus vulgaris-leucoagglutinin (PHA-L) and biocytin, into the striatum and the subthalamic nucleus of squirrel monkeys (Saimiri sciureus) have revealed a high degree of convergence of striatal and subthalamic fibers upon single pallidal cells. Both affe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90648-s

    authors: Hazrati LN,Parent A

    更新日期:1992-01-13 00:00:00

  • Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes.

    abstract::Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.009

    authors: Dodge JC,Badura LL

    更新日期:2004-08-06 00:00:00

  • Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.

    abstract::Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.008

    authors: Dong M,Xi G,Keep RF,Hua Y

    更新日期:2013-04-10 00:00:00

  • Dissociation of mu and delta opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro.

    abstract::Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91312-3

    authors: Lupica CR,Proctor WR,Dunwiddie TV

    更新日期:1992-10-16 00:00:00

  • Reduction by sevoflurane of adenosine 5'-triphosphate-activated inward current of locus coeruleus neurons in pontine slices of rats.

    abstract::Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03125-0

    authors: Masaki E,Kawamura M,Kato F

    更新日期:2001-12-07 00:00:00

  • Goldfish retinotectal transmission in vitro: component current sink-source pairs isolated by varying calcium and magnesium levels.

    abstract::Field potentials and radial current source-densities (CSDs) evoked by optic tract stimulation were observed in goldfish tectum in vitro. The effects of different concentrations of calcium and magnesium were studied to improve understanding of component events in retinotectal transmission and interpretations of effects...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91408-4

    authors: Langdon RB,Manis PB,Freeman JA

    更新日期:1988-02-16 00:00:00

  • Differential effects of duration of sleep fragmentation on spatial learning and synaptic plasticity in pubertal mice.

    abstract:STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.04.037

    authors: Wallace E,Kim DY,Kim KM,Chen S,Blair Braden B,Williams J,Jasso K,Garcia A,Rho JM,Bimonte-Nelson H,Maganti R

    更新日期:2015-07-30 00:00:00

  • Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats.

    abstract::Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.10.085

    authors: Hrnkova M,Zilka N,Minichova Z,Koson P,Novak M

    更新日期:2007-01-26 00:00:00

  • Oxygen therapy improves energy metabolism in focal cerebral ischemia.

    abstract::Oxygen therapy (OT) with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves the oxygenation of penumbral tissue in experimental ischemic stroke. However, whether this results in the improvement of energy metabolism is unclear. We investigated the effect of both OTs on tissue acidosis and on ATP production....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.07.064

    authors: Sun L,Strelow H,Mies G,Veltkamp R

    更新日期:2011-09-30 00:00:00

  • Decreased brainstem function following cardiac arrest and resuscitation in aged rat.

    abstract::There is a high incidence of cardiac arrest and poorer post-resuscitation outcome in the elderly population. Cardiac arrest and resuscitation results in ischemia/reperfusion injury associated with oxidative stress, leading to post-resuscitation mortality and delayed selective neuronal cell loss. In this study we inves...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.02.080

    authors: Xu K,Puchowicz MA,Sun X,LaManna JC

    更新日期:2010-04-30 00:00:00

  • Effects of lesions in the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei on vasopressin and oxytocin in rat brain and spinal cord.

    abstract::The content of arginine vasopressin and oxytocin in various extrahypothalamic sites of the rat brain and spinal cord was determined by specific radioimmunoassays after lesions had been made in either the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei (SCN). In some animals all 3 nuclei were destroye...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91093-5

    authors: Hawthorn J,Ang VT,Jenkins JS

    更新日期:1985-10-28 00:00:00

  • Temporal and anatomical considerations involved in the effects of amygdaloid lesions on prolactin secretion in ovariectomized estrogenized rats.

    abstract::Plasma prolactin (PRL) levels were investigated in chronically catheterized control, sham-lesioned, and amygdala (AMYG)-lesioned rats under a variety of conditions. Ovariectomized (OVX) rats injected with 0.5 mg of polyestradiol phosphate (PEP) exhibited a circadian rhythm of PRL secretion characteristic of proestrus ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90202-4

    authors: Peters JA,Gala RR

    更新日期:1980-04-14 00:00:00

  • Involvement of the heme oxygenase-carbon monoxide-cGMP pathway in the nociception induced by acute painful stimulus in rats.

    abstract::Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful stimulus in the absence of inflammation remains unknown. Thus, we evaluated the involvement of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.02.044

    authors: Carvalho PG,Branco LG,Panissi CR

    更新日期:2011-04-18 00:00:00

  • Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: in vitro anoxia and ouabain exposure.

    abstract::In the present investigation, electron probe X-ray microanalysis was used to characterize the effects of in vitro ouabain (2 mM) or anoxia on elemental composition (e.g. Na, K, Ca) and water content of rat peripheral (tibial) nerve myelinated axons and Schwann cells. Results showed that independent of axon size, both ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00855-k

    authors: Lehning EJ,Doshi R,Stys PK,LoPachin RM Jr

    更新日期:1995-10-02 00:00:00

  • Adaptive plasticity in the primate spinal stretch reflex: reversal and re-development.

    abstract::Monkeys can gradually increase or decrease the amplitude of the segmentally mediated spinal stretch reflex (SSR) without change in initial muscle length or background EMG activity. Both increase (under the SSR increases mode) and decrease (under the SSR decreases mode) occur slowly, progressing steadily over weeks. Th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90259-7

    authors: Wolpaw JR

    更新日期:1983-11-14 00:00:00

  • Sex hormone binding globulin facilitates female sexual receptivity except when coupled to dihydrotestosterone.

    abstract::Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity. SHBG has receptors on plasma membranes of the prostate gland where binding of the 5alpha-reduced androgen di...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02956-6

    authors: Caldwell JD,Höfle S,Englöf I

    更新日期:2002-09-06 00:00:00