Abstract:
:Tyrosine kinase B (TrkB) levels in the adult guinea pig cochlear nucleus (CN) were determined from Western blots for up to 60 days after unilateral cochlear ablation (UCA). Compared to TrkB levels on the intact side, those on the lesioned side were elevated in the anteroventral CN (AVCN) at 7 and 60 days and in the posteroventral CN (PVCN) at 30 days. TrkB levels were depressed in the AVCN and the dorsal CN (DCN) at 30 days. Elevations in the AVCN on the lesioned side at 7 days coincided with a period of synaptogenesis. Other changes were temporally related to up- or downregulations of transmitter release and synaptic receptor activities that were evident after UCA. The findings suggest that changes in signaling through TrkB may contribute to the plasticities in the CN that were evident after UCA.
journal_name
Brain Resjournal_title
Brain researchauthors
Suneja SK,Potashner SJdoi
10.1016/s0006-8993(02)03679-xsubject
Has Abstractpub_date
2002-12-13 00:00:00pages
366-8issue
2eissn
0006-8993issn
1872-6240pii
S000689930203679Xjournal_volume
957pub_type
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