Abstract：
:Extracellular levels of acetylcholine (ACh) were measured in the central nucleus of the amygdala using microdialysis in 20-min intervals before, during, and after 1 h feeding in food-deprived rats. The results were compared to the effects of peripheral injections of glucose or 'low' (200 mU) and 'high' (1 U) doses of insulin. Feeding caused a 40% increase in extracellular ACh in the amygdala during the hour-long meal. Acetylcholine returned to baseline 1 h after food was removed. Systemic injections of either glucose or insulin in ad libitum fed rats also resulted in an increase in ACh levels (+50-60%), but with a different time course. Glucose elevated ACh to a plateau within 20 min for an hour's duration; whereas both doses of insulin caused a peak in ACh release in the first 20 min followed by gradual return to baseline. The 'low' and 'high' doses of insulin had similar effects on ACh release even though they had different hypoglycemic potency as measured in blood samples. These results suggest that ACh in the AMY is involved in feeding and the response to glucose utilization.
journal_name
Brain Resjournal_title
Brain researchauthors
Hajnal A,Pothos EN,Lénárd L,Hoebel BGdoi
10.1016/s0006-8993(97)01291-2subject
Has Abstractpub_date
1998-02-23 00:00:00pages
41-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01291-2journal_volume
785pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The primary olfactory cortex of mouse embryos varying in age from the 13th to the 15th day of gestation is investigated with the aid of several techniques: Nissl and Golgi preparations, autoradiography and electron microscopy. It is observed that the earliest cells to complete their migrations are diffusely scattered ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90641-2
更新日期：1977-03-04 00:00:00
abstract：:The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.031
更新日期：2004-11-12 00:00:00
abstract：:Natural stimulation was used to map the receptive fields of single cells recorded from the rostral medial portion of the dorsal accessory olive (rDAO) and the subjacent principal olive (PO) of the barbiturate anesthetized cat. Previous reports indicated a somatotopic mapping of the entire contralateral body within the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91742-b
更新日期：1993-03-12 00:00:00
abstract：:Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the ph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90097-7
更新日期：1993-10-08 00:00:00
abstract：:We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02920-6
更新日期：2000-11-10 00:00:00
abstract：:Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02014-x
更新日期：2000-03-31 00:00:00
abstract：:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03975-6
更新日期：2003-02-07 00:00:00
abstract：:In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90331-1
更新日期：1978-09-29 00:00:00
abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90433-3
更新日期：1980-09-15 00:00:00
abstract：:Nestin is an embryonic intermediate filament that transiently expressed in the neural stem/progenitor cells in the developing central nervous system (CNS). Growing evidence has shown that abundant expression of nestin also occurs in both pathological glial-derived tumor cells and reactive astrocytes in various CNS inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.026
更新日期：2008-02-27 00:00:00
abstract：:A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03032-9
更新日期：2002-09-20 00:00:00
abstract：:The present in vitro study was performed to characterize neurons within dorsal regions of the nucleus tractus solitarii (NTS), principally at the level of area postrema, and known to receive inputs predominantly from cardiovascular and respiratory afferents (i.e. cardiorespiratory NTS). This report describes 4 classes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90358-t
更新日期：1993-02-26 00:00:00
abstract：:Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.061
更新日期：2007-07-02 00:00:00
abstract：:The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02412-9
更新日期：2000-02-21 00:00:00
abstract：:Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodiu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90426-8
更新日期：1979-01-12 00:00:00
abstract：:The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90384-5
更新日期：1982-01-14 00:00:00
abstract：:The effects of unilateral intrahippocampal injections of the non-competitive NMDA receptor antagonist, MK-801, on local cerebral glucose utilisation have been examined in conscious rats using [14C]2-deoxyglucose autoradiography. The intrahippocampal injection of MK-801 (10 nmol) induced significant marked increases in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90995-n
更新日期：1990-06-04 00:00:00
abstract：:A normobar hypoxia (9% oxygen) of 8 h reduces the neurotoxicity of a subcutaneous injection of 10 mg/kg kainic acid given one week later. Both seizures and degenerative changes, including cell death of hippocampal and cortical neurons are markedly decreased by hypoxia. It is also shown that hypoxia also markedly reduc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91693-4
更新日期：1994-05-02 00:00:00
abstract：:The VIIIth cranial nerve projections in the hagfish, which has only one circular canal in the ear, were studied by transganglionic HRP transport. This nerve has two branches, the nervus utricularis (N. utr.) and the nervus saccularis (N. sac.), each with its own ganglion, the ganglion utriculare (G. utr.) and the gang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91610-5
更新日期：1985-06-24 00:00:00
abstract：:Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.058
更新日期：2009-04-10 00:00:00
abstract：:Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91187-3
更新日期：1983-11-28 00:00:00
abstract：:Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90160-2
更新日期：1980-12-08 00:00:00
abstract：:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.034
更新日期：2009-01-16 00:00:00
abstract：:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91005-2
更新日期：1976-09-10 00:00:00
abstract：:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.013
更新日期：2004-06-04 00:00:00
abstract：:Slices of the molecular layer of the dentate gyrus of the hippocampal formation were incubated with either [14C]glucose, [14C]pyruvate or 14C glutamine and the efflux of endogenous and radioactive glutamate was monitored under various conditions. After prelabeling with either [14C]glutamine or [14C]glucose elevation o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90306-8
更新日期：1979-06-08 00:00:00
abstract：:Labyrinthine-intact guinea pigs received unilateral, brainstem cannula injections of (1) 2.5 micrograms of the selective dihydropyridine L-type Ca2+ channel agonist, Bay K 8644 (n = 4 animals); (2) 10 micrograms Bay K 8644 (n = 4); 12.5 micrograms of the selective dihydropyridine L-type Ca2+ channel antagonist, nifedi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90677-f
更新日期：1993-12-10 00:00:00
abstract：:In this study, a single unit activity was recorded in the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla of anesthetized, morphine-dependent rats. The spontaneous activity of PGi neurons was significantly decreased by administration of morphine (10 mg/kg; i.p.) in sham-operated, cont...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01029-4
更新日期：1998-12-14 00:00:00
abstract：:Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91094-h
更新日期：1991-02-08 00:00:00
abstract：:The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90071-6
更新日期：1988-08-02 00:00:00
