Abstract:
:Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition changes. This disproportionate decline in energy expenditure would not be sufficient to account for the over 80% recidivism rate to pre-weight loss levels of body fatness after otherwise successful weight reduction if there were a corresponding reduction in energy intake. In fact, reduced body weight maintenance is accompanied by increased energy intake above that required to maintain reduced weight. The failure to reduce energy intake in response to decreased energy output reflects decreased satiation and perception of how much food is eaten and multiple changes in neuronal signaling in response to food which conspire with the decline in energy output to keep body energy stores (fat) above a CNS-defined minimum (threshold). Much of this biological opposition to sustained weight loss is mediated by the adipocyte-derived hormone "leptin."
journal_name
Brain Resjournal_title
Brain researchauthors
Rosenbaum M,Kissileff HR,Mayer LE,Hirsch J,Leibel RLdoi
10.1016/j.brainres.2010.05.062subject
Has Abstractpub_date
2010-09-02 00:00:00pages
95-102eissn
0006-8993issn
1872-6240pii
S0006-8993(10)01266-7journal_volume
1350pub_type
杂志文章,评审相关文献
BRAIN RESEARCH文献大全abstract::Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.048
更新日期:2003-12-24 00:00:00
abstract::Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.047
更新日期:2015-01-12 00:00:00
abstract::We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91089-b
更新日期:1993-07-23 00:00:00
abstract::Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats. The morphine-induced increase in DA oxidative metabolism is highly correlated with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00371-0
更新日期:1998-06-22 00:00:00
abstract::To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.007
更新日期:2017-10-15 00:00:00
abstract::Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.078
更新日期:2010-12-17 00:00:00
abstract::Increased permeability of the brain-blood barrier (BBB) in the piriform cortex (PC) has been reported in various animal models of temporal lobe epilepsy. Since BBB disruption induced by epileptogenic insult has not fully clarified, we attempted to determine whether changes in BBB-related molecules are associated with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.080
更新日期:2011-01-19 00:00:00
abstract::The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.016
更新日期:2004-09-03 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01461-p
更新日期:1995-02-27 00:00:00
abstract::Partial sciatic nerve ligation in mice caused a marked and persistent decrease in the latency of paw withdrawal from a thermal stimulus only on the ipsilateral side. This thermal hyperalgesia was abolished by repeated intrathecal pretreatment with a specific antibody to brain-derived neurotrophic factor (BDNF), but no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03666-1
更新日期:2002-12-27 00:00:00
abstract::The current study was performed to evaluate the mechanisms and therapeutic effects of overexpressing neuroglobin (Ngb) on spinal cord injury (SCI). Adeno-associated virus (AAV) was injected in the T12 section 7 days before SCI. Animals were randomly divided into four groups: a sham group, a vehicle group, an AAV-EGFP ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.03.020
更新日期:2014-05-08 00:00:00
abstract::Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00123-8
更新日期:1995-03-27 00:00:00
abstract:UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90847-4
更新日期:1986-02-05 00:00:00
abstract::The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90238-6
更新日期:1988-08-01 00:00:00
abstract::The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90239-2
更新日期:1987-12-15 00:00:00
abstract::Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03178-5
更新日期:2002-10-04 00:00:00
abstract::Effects of inhibition of nitric oxide (NO) synthesis on the cerebrovascular autoregulatory vasodilator response to hypotension were studied in conscious rats. Cerebral blood flow (CBF) was determined with [14C]iodoantipyrine in a saline-treated control group and in three groups following inhibition of NO synthase acti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00129-e
更新日期:1995-04-24 00:00:00
abstract::The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be inc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.07.003
更新日期:2011-09-09 00:00:00
abstract::The localization of serotonergic, various peptidergic and possibly cholinergic neurons in the medullary raphe nuclei that project to the lumbosacral spinal cord have been studied using a retrograde transport method combined with immunocytochemical and histochemical techniques. Spinally projecting neurons stained for s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90079-3
更新日期:1983-12-12 00:00:00
abstract::While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.06.032
更新日期:2016-09-01 00:00:00
abstract::A Rous Sarcoma virus transformed cerebellar cell line, BC6, secretes a factor which causes clonal glial cell lines to rapidly (1 h) extend processes. The factor shows a degree of specificity since only 3 out of 10 lines which exhibit either glial or combined glial and neuronal properties respond. The active factor app...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90214-6
更新日期:1983-12-01 00:00:00
abstract::Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91337-g
更新日期:1990-08-13 00:00:00
abstract::Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.089
更新日期:2007-02-02 00:00:00
abstract::There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02965-7
更新日期:2002-09-13 00:00:00
abstract::Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90481-1
更新日期:1987-11-03 00:00:00
abstract::Glutamate induced responses in the surface membrane of Xenopus oocyte by injection with mRNA from crustacea and insect muscle. Glutamate (10(-5) to 10(-4) M) elicited smooth current responses which resembled those induced by kainate. This smooth current reversed direction at about 0 mV and was blocked by a spider toxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90048-9
更新日期:1987-12-01 00:00:00
abstract::A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.014
更新日期:2007-12-05 00:00:00
abstract::The relationship between seizure propensity and the vascular anatomy of the anterior cerebral arteries, or stroke induced by unilateral ligation of the common carotid artery, was investigated utilizing well differentiated colonies of seizure-prone (SP) and non-seizure-prone (NSP) gerbils. Twenty SP and 20 NSP gerbils ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90867-8
更新日期:1982-02-25 00:00:00
abstract::A major effect of volatile anesthetics is to reduce excitatory synaptic transmission. In the present study the stimulated release of glutamate under the influence of increasing concentrations of isoflurane was studied in vitro by utilizing hippocampal slices from Wistar rats. Ca(2+)-dependent release was calculated by...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91282-3
更新日期:1994-11-14 00:00:00
abstract::Acute and chronic abuses of psychostimulant drugs such as methamphetamine (METH) have been known to cause cell death. In particular, neurotoxicity caused by such drugs is one of the most serious adverse events in humans. Although various effects on neuronal cells caused by METH have been studied, the cellular and mole...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.043
更新日期:2010-09-17 00:00:00