Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.

abstract：:We electrically stimulated individual Mauthner (M-) cells to determine their motor contribution to C-starts of swimming goldfish. In comparison with sensory-evoked C-starts, M-reflexes triggered by electrical stimulation of single M-cells were significantly weaker and less variable. Stage 1 turns were both longer in d...

journal_title：Brain research

authors： Nissanov J,Eaton RC,DiDomenico R

更新日期：1990-05-28 00:00:00

abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...

journal_title：Brain research

authors： van der Kooy D,Carter DA

更新日期：1981-04-27 00:00:00

abstract：:The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...

journal_title：Brain research

authors： Devesa A,O'Connor JE,Garciá C,Puertes IR,Viña JR

更新日期：1993-08-06 00:00:00

abstract：:Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colo...

journal_title：Brain research

authors： Glösmann M,Ahnelt PK

更新日期：2002-03-01 00:00:00

abstract：:The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...

journal_title：Brain research

authors： Freudenthal R,Romano A

更新日期：2000-02-14 00:00:00

abstract：:We have developed a novel imaging system "real-time bioradiography", which is able to estimate the dynamic changes of physiological function and metabolism in living tissues using positron emitter-labeled tracers and chemiluminescence probes. The apparatus is comprised of a photon-counting camera, image-controller, cu...

journal_title：Brain research

authors： Sasaki T,Iwamoto A,Tsuboi H,Watanabe Y

更新日期：2006-03-10 00:00:00

abstract：:The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...

journal_title：Brain research

authors： Fukuda H,Tomimatsu T,Watanabe N,Mu JW,Kohzuki M,Endo M,Fujii E,Kanzaki T,Murata Y

更新日期：2001-08-10 00:00:00

abstract：:The effects of local and global context on concurrent sound segregation were examined using a mistuned harmonic paradigm. Presented with the same sounds over three conditions, participants were asked to either categorise the incoming complex according to pitch or harmonicity (active listening) or watch a muted subtitl...

journal_title：Brain research

authors： Dyson BJ,Alain C

更新日期：2008-01-16 00:00:00

abstract：:The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...

journal_title：Brain research

authors： Meng SZ,Ozawa Y,Itoh M,Takashima S

更新日期：1999-10-02 00:00:00

abstract：:Recent experimental data have shown that hyperbaric oxygen therapy (HBOT) was associated increased Bcl-2 expression at the injury site that correlated with reduced apoptosis. We hypothesized that HBOT mediated enhancement of Bcl-2 expression and increased intracellular oxygen bio-availability may both contribute to pr...

journal_title：Brain research

authors： Palzur E,Zaaroor M,Vlodavsky E,Milman F,Soustiel JF

更新日期：2008-07-24 00:00:00

abstract：:Rarely do we encounter a single odorant in our environment. Perception of odours, therefore, usually depends on the reception and neural processing of many components. However, little is known about how and where odour mixtures are processed. Evidence is presented here that suppression of one odour by another, a commo...

journal_title：Brain research

authors： Bell GA,Laing DG,Panhuber H

更新日期：1987-11-17 00:00:00

abstract：:Previous observations show that neonatal removal of nerve growth factor results in an increased number of fine dorsal root axons in the adult animal. The present study shows that the same treatment results in 49% more axons in the adult tract of Lissauer, which is an area of spinal white matter that contains predomina...

journal_title：Brain research

authors： Hulsebosch CE,Coggeshall RE

更新日期：1988-10-04 00:00:00

abstract：:Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...

journal_title：Brain research

authors： Pickel VM,Chan J,Sesack SR

更新日期：1993-02-05 00:00:00

abstract：:Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(ΔE9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mic...

journal_title：Brain research

authors： Kalifa S,Polston EK,Allard JS,Manaye KF

更新日期：2011-02-28 00:00:00

abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...

journal_title：Brain research

authors： Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto M

更新日期：2003-12-12 00:00:00

abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

journal_title：Brain research

authors： Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

更新日期：2009-12-01 00:00:00

abstract：:The sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. Four sham-lesioned males served as controls. Lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypot...

journal_title：Brain research

authors： Lloyd SA,Dixson AF

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:To determine whether antisense oligonucleotides (AODNs) targeted against CRX, a photoreceptor-specific trans-acting factor, suppress CRX expression and interphotoreceptor retinoid binding protein (IRBP) promoter activity. METHODS:Cultures of human retinoblastoma cells were transfected with chloramphenicol acet...

journal_title：Brain research

authors： Boatright JH,Borst DE,Stodulkova E,Nickerson JM

更新日期：2001-10-19 00:00:00

abstract：:Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals...

journal_title：Brain research

authors： Nation JR,Livermore CL,Bratton GR

更新日期：1995-12-08 00:00:00

abstract：:Motoneurons in the lumbar spinal cord of chick embryos 6 days old, the age when their cell death starts, were labeled in vivo by retrograde axonal transport of horseradish peroxidase (HRP) and then cultured as cord fragments or isolated cells. In Eagle's minimum essential medium with no additives, spinal cord cells su...

journal_title：Brain research

authors： Tanaka H,Obata K

更新日期：1983-09-01 00:00:00

abstract：:In an attempt to demonstrate a protective effect against convulsions induced by hyperbaric oxygen (OHP), aminooxyacetic acid (AOAA at 2.5 mg/kg) was administered subcutaneously to 60 white leghorn cockerels (aged 21-28 days) at periods of 1-72 h before exposure to OHP. A transient protection was noted 1-8 h after admi...

journal_title：Brain research

authors： Davison AJ

更新日期：1983-10-16 00:00:00

abstract：:We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...

journal_title：Brain research

authors： Czigler I,Winkler I,Pató L,Várnagy A,Weisz J,Balázs L

更新日期：2006-08-09 00:00:00

abstract：:(1) The levels of glycolytic intermediates in the brain tissue of 15-day-old homozygous and heterozygous Gunn rats were determined with or without novobiocin treatment in vivo, and the inhibitory effects of bilirubin on the glycolytic activity and the key glycolytic enzyme activities were investigated in vitro. (2) t...

journal_title：Brain research

authors： Katoh-Semba R

更新日期：1976-08-27 00:00:00

abstract：:The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...

journal_title：Brain research

authors： Ren C,Zoltewicz S,Guingab-Cagmat J,Anagli J,Gao M,Hafeez A,Li N,Cao J,Geng X,Kobeissy F,Mondello S,Larner SF,Hayes RL,Ji X,Ding Y

更新日期：2013-12-02 00:00:00

abstract：:We have previously shown that NS-7 [4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride] reduces the size of cerebral infarction measured by 2,3,5-triphenyltetrazolium chloride staining at 48 h after permanent middle cerebral artery occlusion (MCAO) in rats. To determine whether NS-7 improves...

journal_title：Brain research

authors： Tamura M,Aoki Y,Seto T,Itoh Y,Ukai Y

更新日期：2001-01-26 00:00:00

abstract：:The effects of different ionic media on Ca2+ uptake and release in isolated brain microsomes were investigated. KCl (100 mM) provided the best medium for Ca2+ uptake in the presence of ATP. The effect of myo-inositol 1,4,5-trisphosphate (IP3) on Ca2+ release was examined and was maximum at 0.2 microM. IP3-induced Ca2+...

journal_title：Brain research

authors： Shah J,Cohen RS,Pant HC

更新日期：1987-09-01 00:00:00

abstract：:An initial decrement followed by a significant recovery of choline acetyltransferase and acetylcholinesterase activities in the ipsilateral hippocampus was observed in rats with unilateral, partial transection of the fimbria. Regeneration of hippocampal cholinergic terminals could account for the parallel return towar...

journal_title：Brain research

authors： Dravid AR,van Deusen EB

更新日期：1983-10-24 00:00:00

abstract：:Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...

journal_title：Brain research

authors： Miyoshi Y,Date I,Ohmoto T

更新日期：1995-05-29 00:00:00

abstract：:Evidence is presented which suggests that central neural changes occur during the brief early phase after subcutaneous formalin injection that are essential for the expression of pain during the long-lasting (tonic) later phase. First, tonic pain responses to subcutaneous formalin injections are abolished only if the ...

journal_title：Brain research

authors： Coderre TJ,Vaccarino AL,Melzack R

更新日期：1990-12-03 00:00:00

abstract：:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...

journal_title：Brain research

authors： Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A

更新日期：2010-06-25 00:00:00