Inositol trisphosphate-induced calcium release in brain microsomes.

Abstract:

:The effects of different ionic media on Ca2+ uptake and release in isolated brain microsomes were investigated. KCl (100 mM) provided the best medium for Ca2+ uptake in the presence of ATP. The effect of myo-inositol 1,4,5-trisphosphate (IP3) on Ca2+ release was examined and was maximum at 0.2 microM. IP3-induced Ca2+ release was dependent on extramicrosomal free Ca2+ concentration with maximal release at 5.0 microM free Ca2+. Replacement of KCl by sucrose or NaCl did not show any response to IP3. Electron microscopy showed that the microsomal fraction consisted of characteristic endoplasmic reticulum-derived vesicular profiles and were free of mitochondria or plasma membrane contamination. Our results support the concept that the endoplasmic reticulum is the target for IP-3 induced mobilization of Ca2+ in the cell.

journal_name

Brain Res

journal_title

Brain research

authors

Shah J,Cohen RS,Pant HC

doi

10.1016/0006-8993(87)90562-2

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

1-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90562-2

journal_volume

419

pub_type

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