Abstract:
:Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals from each condition received 12 repeated daily i.p. injections of 10 mg/kg cocaine-HCl, or saline. Locomotor activity (total distance traveled) was recorded in Digiscan Activity Monitors for a 20-min baseline period prior to each injection, and for a 40-min period post-injection. On Day 13 of testing, all animals received saline injections only in the test chambers, in an effort to evaluate the role of conditioned cues in the expression of cocaine sensitization. On Day 14-16 of testing, all animals received successive daily challenges of 10, 20, and 40 mg/kg cocaine in the test chamber. The results indicated that the initiation (development) of behavioral sensitization to 10 mg/kg cocaine was attenuated in cadmium-exposed rats. Moreover, the supersensitivity to higher doses of cocaine during dose-effect testing that was registered by control animals pretreated with cocaine, was not evident in cadmium-exposed pretreatment animals. These data suggests that environmental contaminants may alter drug responsiveness, and thereby may influence patterns of drug selection and use.
journal_name
Brain Resjournal_title
Brain researchauthors
Nation JR,Livermore CL,Bratton GRdoi
10.1016/0006-8993(95)01060-2subject
Has Abstractpub_date
1995-12-08 00:00:00pages
223-32issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01060-2journal_volume
702pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.12.085
更新日期:2009-05-19 00:00:00
abstract::L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.065
更新日期:2003-12-12 00:00:00
abstract::A commissural-associational entorhino-entorhinal projection in the guinea pig was analyzed using anterograde and retrograde axonal tracing techniques. The projection originated in layer II and terminated in layer Ia of both the medial entorhinal area (MEA) and the lateral entorhinal area (LEA). A few cells in other la...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90117-0
更新日期:1989-12-25 00:00:00
abstract::Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01522-x
更新日期:1999-07-03 00:00:00
abstract::The effect of chronic ethanol administration on the fine structure of the hippocampal CA1 stratum oriens was examined in two lines of mice selectively bred for their differential sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS mice). Two experiments were performed. In the first experiment, mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90718-9
更新日期:1987-04-21 00:00:00
abstract::The demyelination (dmy) rat is a unique mutant exhibiting severe myelin breakdown in the central nervous system (CNS). In this study, we conducted immunohistochemical and morphometrical investigations in the dmy rat. From around 6 weeks of age, the affected rats developed ataxia especially in the hindlimbs. Afterwards...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.007
更新日期:2004-10-01 00:00:00
abstract::In this study, we observed the chronological alterations of neurofilament 150 (NF-150) immunoreactivity in the gerbil hippocampus and dentate gyrus after 5 min transient forebrain ischemia. NF-150 immunoreactivity in the sham-operated group was mainly detected in mossy fibers and in the hilar region of the dentate gyr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.001
更新日期:2004-07-30 00:00:00
abstract::It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90234-5
更新日期:1989-08-28 00:00:00
abstract::Putative N-type voltage-sensitive calcium channels were localized autoradiographically in thaw-mounted rat brain slices using [125I]omega-conotoxin GVIA as a ligand. Density of the toxin binding sites were highly heterogeneous throughout the brain. The highest density of the binding sites was observed in the glomerula...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90790-1
更新日期:1988-06-07 00:00:00
abstract::Anterograde and retrograde tracing experiments employing WGA-HRP were used to identify an auditory projection area within the frontal telencephalon of the pigeon. The projection originates in a nucleus of the lateral lemniscus, travels with the quintofrontal tract and terminates within nucleus basalis. The location of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91499-x
更新日期:1986-11-29 00:00:00
abstract::Up to today, the neuronal bases of activating and establishing a memory trace are not well understood. Several findings point towards the idea that the activation of an engram is mirrored in induced oscillatory bursts in the gamma frequency range (> 20 Hz; induced gamma band responses; iGBRs). In the present study, we...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.069
更新日期:2006-06-30 00:00:00
abstract::Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90164-9
更新日期:1989-08-07 00:00:00
abstract::The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90316-f
更新日期:1993-09-03 00:00:00
abstract::Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.050
更新日期:2008-03-27 00:00:00
abstract::We have developed a serum-free chemically defined medium which allows the obtainment of a primary culture highly enriched in ciliated ependymal cells. Serum was never used. Mechanically dissociated neonatal rat brain hemisphere cells were seeded on a fibronectin substratum. Culture medium was minimum Eagle's medium un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80228-1
更新日期:1986-03-01 00:00:00
abstract::Development of noradrenergic responses in the rat dorsal motor nucleus of the vagus (DMV) from postnatal days 0 to 22 was studied by a conventional microelectrode technique using brain slice preparations. Between postnatal days 0 and 6, noradrenaline (NA) caused only alpha 1-adrenoceptor-mediated depolarizations. By p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91170-0
更新日期:1989-07-31 00:00:00
abstract::Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02086-8
更新日期:2001-04-06 00:00:00
abstract::The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.071
更新日期:2007-07-23 00:00:00
abstract::Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01284-2
更新日期:1995-12-24 00:00:00
abstract:INTRODUCTION:Ischemic postconditioning (IpostC) has been described in both heart and brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and neurological function in the middle cerebral artery occlusion (MCAO) model. The second aim was to determine the involvement of the mitoc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.054
更新日期:2011-02-23 00:00:00
abstract::We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems). In the tail-pinch test, the antinociceptive effect of DSIP was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91569-2
更新日期:1989-02-20 00:00:00
abstract::Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91163-7
更新日期:1986-10-08 00:00:00
abstract::Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.006
更新日期:2015-11-02 00:00:00
abstract::The present experiments describe the effect of NMDA and kainate agonists of the NMDA and non-NMDA subtype of receptors respectively of the excitatory amino acids (EAAs) system in prepubertal (16 days of age) and peripubertal (30-day-old rats) male rats on the in vitro hypothalamic release of GnRH, and on the in vivo L...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01216-8
更新日期:1996-01-29 00:00:00
abstract::The ultrastructural localizations of rat corticoliberin (rCRF) and methionine-enkephalin octapeptide (Met-Enk-8) in the external layer of the rat median eminence were examined by double-immunogold labeling with anti-rCRF and anti-Met-Enk-8 sera labeled with small-sized (Gs) and medium-sized (Gm) gold particles, respec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90487-7
更新日期:1986-04-09 00:00:00
abstract::Retinal lesions in pigeons produced a marked depletion of somata and neuropil staining for both calbindin-D28k and parvalbumin immunoreactivities in the contralateral optic tectum. Calbindin-like immunoreactivity reappeared in some tectal layers by 6 weeks postlesion, whereas paravalbumin-like immunoreactivity recover...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91206-8
更新日期:1994-10-24 00:00:00
abstract::Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.094
更新日期:2007-10-26 00:00:00
abstract::Co-activation of group I metabotropic glutamate (mGlu) receptors and adenosine receptors resulted in an augmented cyclic AMP response in primary cultures of rat striatal neurones. L-glutamate and the selective group I agonist, (S)-dihydroxyphenylglycine (S-DHPG) evoked concentration-dependent potentiations of cyclic A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00094-8
更新日期:1998-04-27 00:00:00
abstract::We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91085-1
更新日期:1986-10-22 00:00:00
abstract::Intracisternal (i.c.) administration of the endogenous tridecapeptide neurotensin (NT) has been previously shown to significantly reduce the incidence of cold-restraint stress (CRS)-induced gastric ulcers in rats. In this study we confirm the cytoprotective activity of central NT, and document structure-activity relat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90414-1
更新日期:1984-05-28 00:00:00