Aging and neuropathic pain.

Abstract:

:Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation of the left sciatic nerve. The extent to which the aging process affects the thermal hyperalgesic responsiveness of these animals was investigated. The results demonstrate that the aging process differentially alters nociceptive processing.

journal_name

Brain Res

journal_title

Brain research

authors

Novak JC,Lovell JA,Stuesse SL,Cruce WL,McBurney DL,Crisp T

doi

10.1016/s0006-8993(99)01522-x

subject

Has Abstract

pub_date

1999-07-03 00:00:00

pages

308-10

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01522-X

journal_volume

833

pub_type

杂志文章
  • Modulation of the myotatic reflex gain in man during intentional movements.

    abstract::Human subjects were asked to perform sinusoidal tracking movements (0.5--3.0 Hz) with their forearms while external torque disturbances were applied at the elbow. The changes in angular position, velocity, and acceleration produced by these disturbances were found to be represented in the reflex changes in EMG activit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90946-4

    authors: Dufresne JR,Soechting JF,Terzuolo CA

    更新日期:1980-07-07 00:00:00

  • Modulation of sodium currents in rat sensory neurons by nucleotides.

    abstract::The effects of various nucleotides on the fast tetrodotoxin-sensitive (f-TTX-S) and the slow tetrodotoxin-resistant (s-TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were investigated using the patch-clamp technique. Nucleoside triphosphates (NTPs; ATP, GTP, UTP and CTP) and nucleoside diphosphates (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.01.061

    authors: Park SY,Kim HI,Shin YK,Lee CS,Park M,Song JH

    更新日期:2004-05-01 00:00:00

  • Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development.

    abstract::A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2018.02.046

    authors: Chou SJ,Tole S

    更新日期:2019-02-15 00:00:00

  • A topographic measurement of brain pH.

    abstract::The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90869-0

    authors: Kogure K,Alonso OF,Martinez E

    更新日期:1980-08-11 00:00:00

  • Effects of xanthine derivatives on electroretinographic responsiveness.

    abstract::In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02328-3

    authors: Andjus RK,Konjević D,Damjanović I,Gacić Z

    更新日期:2000-06-23 00:00:00

  • Relationship among fMRI, contrast sensitivity and visual acuity.

    abstract::The purpose of this study was to ascertain whether visual acuity or contrast sensitivity function (CSF) is proportional to visual cortical function based on fMRI volume and level of activation or Z-score. Forced choice procedures were utilized to measure the monocular log minimal angle of resolution (logMAR) visual ac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.10.082

    authors: Leguire LE,Algaze A,Kashou NH,Lewis J,Rogers GL,Roberts C

    更新日期:2011-01-07 00:00:00

  • Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test.

    abstract::Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic system in mice is affected by EP-MRI. The short- and long-term effects of EP-MRI on immobil...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.08.011

    authors: Aksoz E,Aksoz T,Bilge SS,Ilkaya F,Celik S,Diren HB

    更新日期:2008-10-21 00:00:00

  • Retinotopically inappropriate synapses of subnormal density formed by surgically misdirected optic fibers in goldfish tectum.

    abstract::Selected optic fibers were surgically deflected from one tectum onto the opposite host tectum which was denervated by eye enucleation. At 6-8 months, deflected fibers were labeled with horseradish peroxidase and the retinotopically inappropriate part of tectum was examined using electron microscopy. Numerous (labeled)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(88)90058-2

    authors: Hayes WP,Meyer RL

    更新日期:1988-02-01 00:00:00

  • Intracortical connections of the anterior ectosylvian and lateral suprasylvian visual areas in the cat.

    abstract::Intra- and interhemispheric connections between the anterior ectosylvian visual area (AEV) and other visual cortical areas including the lateral suprasylvian (LSS) were examined in the cat using the retrograde double-label fluorescence technique. The areal and laminar distributions of labeled neurons were mapped follo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90189-1

    authors: Miceli D,Repérant J,Ptito M

    更新日期:1985-11-18 00:00:00

  • Effect of MK-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus.

    abstract::Several investigations have shown that the N-methyl-D-aspartate (NMDA) antagonist MK-801 interferes both with learning and a candidate neural mechanism for learning, the long-term potentiation (LTP) phenomenon. The low doses of MK-801 reported to block learning, however, may not be sufficient to block LTP. The present...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90371-f

    authors: Robinson GB,Reed GD

    更新日期:1992-01-08 00:00:00

  • Afferent projections related to attack sites in the pontine tegmentum.

    abstract::Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90009-x

    authors: Smith DA,Flynn JP

    更新日期:1979-03-23 00:00:00

  • Reduction of [3H]muscimol binding sites in rat dorsal spinal cord after neonatal capsaicin treatment.

    abstract::Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90160-2

    authors: Singer E,Placheta P

    更新日期:1980-12-08 00:00:00

  • Cerebrospinal fluid (CSF) and brain monoamine metabolites in the developing rat pup.

    abstract::Concentrations of the neurotransmitters, serotonin (5-HT), dopamine (DA), and norepinephrine (NE) were measured in the developing rat brain at 12, 19, 26 and 42 days of age. The amino acid precursors, tryptophan (TRP) and tyrosine (TYR) were measured along with the 5-HT and DA metabolites, 5-hydroxyindoleacetic acid (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90146-4

    authors: Shaywitz BA,Anderson GM,Cohen DJ

    更新日期:1985-01-01 00:00:00

  • The time course of semantic and orthographic encoding in Chinese word production: an event-related potential study.

    abstract::Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.03.049

    authors: Zhang Q,Damian MF

    更新日期:2009-06-01 00:00:00

  • An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

    abstract::Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.11.065

    authors: Ziobro JM,Deshpande LS,Delorenzo RJ

    更新日期:2011-01-31 00:00:00

  • Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice.

    abstract::Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.11.017

    authors: Allah Yar R,Akbar A,Iqbal F

    更新日期:2015-01-21 00:00:00

  • Sex hormone binding globulin stimulates female sexual receptivity.

    abstract::Sex hormone binding globulin (SHBG) is found in the brain and acts directly on plasma membrane-associated receptors in the prostate gland. Infusing SHBG into the medial preoptic area or medial basal hypothalamus of female rats increases their female sexual receptivity. SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E pl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02569-5

    authors: Caldwell JD,Moe BD,Hoang J,Nguyen T

    更新日期:2000-08-18 00:00:00

  • Dynamic responses of presynaptic terminal membrane pools following KCl and sucrose stimulation.

    abstract::The cholinergic presynaptic terminals of Torpedo electric organ have been examined morphometrically following stimulation by KCI and sucrose. The objective was to confirm correlations predicted by the vesicle hypothesis between miniature end-plate potentials (MEPPs) and morphometric changes in terminal ultrastructure....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00109-1

    authors: Fox GQ,Kriebel ME

    更新日期:1997-04-25 00:00:00

  • Reduction of fetal rat spinal cord volume following maternal morphine injection.

    abstract::Previous studies have shown behavioral changes in pre- and postnatal rats exposed to morphine before and during gestation. The present study has attempted to discover morphological correlates of these changes in the fetal rat spinal cord. Pregnant Wistar rats were injected subcutaneously on days 12-18 of gestation wit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Kirby ML

    更新日期:1980-11-24 00:00:00

  • Fluid reasoning deficits in children with ADHD: evidence from fMRI.

    abstract::Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with deficits in fluid reasoning, which may be related to self-regulation of cognition and behavior, and requires intact attention, working memory, and inhibition skills. No functional magnetic resonance imaging (fMRI) studies have directly examined fluid r...

    journal_title:Brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.brainres.2012.05.021

    authors: Tamm L,Juranek J

    更新日期:2012-07-17 00:00:00

  • A histologically derived stereotaxic atlas and substance P immunohistochemistry in the brain of the least shrew (Cryptotis parva) support its role as a model organism for behavioral and pharmacological research.

    abstract::Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alte...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.04.061

    authors: Ray AP,Darmani NA

    更新日期:2007-07-02 00:00:00

  • Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to omega-conotoxin.

    abstract::The presynaptic neurotoxin omega-conotoxin (omega-CgTx) was tested for its ability to inhibit voltage-dependent calcium flux and transmitter release in rat brain synaptosomes. Conotoxin (0.001-10 microM) had no effect on calcium uptake or endogenous dopamine release from rat striatal synaptosomes in the absence of pot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90207-7

    authors: Woodward JJ,Rezazadeh SM,Leslie SW

    更新日期:1988-12-13 00:00:00

  • Haemorrhage-induced release of noradrenaline, 5-hydroxytryptamine and uric acid in the supraoptic nucleus of the rat, measured by microdialysis.

    abstract::Concentrations of monoamines and metabolites and uric acid were measured in sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease in blood pressure of 40 mm Hg was induced by withdrawing 3-4 ml of blood from an indwelling jugular cathet...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91016-5

    authors: Kendrick KM,Leng G

    更新日期:1988-02-09 00:00:00

  • Menstrual cycle phase modulates cognitive control over male but not female stimuli.

    abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.05.061

    authors: Roberts GM,Newell F,Simões-Franklin C,Garavan H

    更新日期:2008-08-11 00:00:00

  • Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder.

    abstract::A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it is proposed that a hyper-responsi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.09.038

    authors: Brace LR,Kraev I,Rostron CL,Stewart MG,Overton PG,Dommett EJ

    更新日期:2015-12-10 00:00:00

  • NMDA receptor antagonist blocks the bradycardic but not the pressor response to L-glutamate microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats.

    abstract::In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/S0006-8993(96)01169-9

    authors: Colombari E,Bonagamba LG,Machado BH

    更新日期:1997-02-28 00:00:00

  • NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion.

    abstract::Transient ischemia increases tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor. Several tyrosine kinases are involved in this process. In this study, effect of ischemia and reperfusion (I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02619-1

    authors: Liu Y,Zhang G,Gao C,Hou X

    更新日期:2001-08-03 00:00:00

  • Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice.

    abstract::Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00848-8

    authors: Ling GY,Cao WH,Onodera M,Ju KH,Kurihara H,Kurihara Y,Yazaki Y,Kumada M,Fukuda Y,Kuwaki T

    更新日期:1998-10-19 00:00:00

  • The nigrostriatal dopamine system: role in the development of hypertension in spontaneously hypertensive rats.

    abstract::The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91739-6

    authors: Linthorst AC,van Giersbergen PL,Gras M,Versteeg DH,de Jong W

    更新日期:1994-03-14 00:00:00

  • Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats.

    abstract::The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01952-6

    authors: Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

    更新日期:1999-10-16 00:00:00