Abstract：
:Intracisternal (i.c.) administration of the endogenous tridecapeptide neurotensin (NT) has been previously shown to significantly reduce the incidence of cold-restraint stress (CRS)-induced gastric ulcers in rats. In this study we confirm the cytoprotective activity of central NT, and document structure-activity relationships for this effect of NT. When tested in a dose equimolar to 17.9 nmol of NT the NT analogs [Gln4]NT, D-Trp11-NT, and D-Arg8-NT were cytoprotective, whereas D-Arg9-NT was not. Gonadotropin-releasing hormone (Gn-RH) and melanocyte-stimulating hormone-release inhibiting factor (MIF-1), two oligopeptides structurally unrelated to NT exhibited no cytoprotective efficacy in this paradigm. The C-terminal fragments of NT, xenopsin and NT8-13, and the N-terminal fragment NT1-6 were completely ineffective. Finally, NT1-8 and NT1-10, two N-terminal fragments of NT produced significant cytoprotective activity at this dose level. The cytoprotection afforded by NT1-8 and NT1-10, like that of NT, was dose-dependent with ED50's similar to that of NT (NT = 16.2 nmol, NT1-8 = 17.8 nmol and NT1-10 = 19.9 nmol). In conclusion, we demonstrate that smaller molecular weight forms of NT thought to be degradation products of NT can effectively exert biological effects.
journal_name
Brain Resjournal_title
Brain researchauthors
Hernandez DE,Richardson CM,Nemeroff CB,Orlando RC,St-Pierre S,Rioux F,Prange AJ Jrdoi
10.1016/0006-8993(84)90414-1subject
Has Abstractpub_date
1984-05-28 00:00:00pages
153-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90414-1journal_volume
301pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Ventilated, chloralose anesthetized cats were subjected to 3.2 atmosphere fluid percussion injury and compared with sham operated controls. In both groups, global cerebral blood flow (CBF), cerebral metabolic rate of oxygen utilization (CMRO2), cerebral metabolic rate of glucose utilization (CMRG1), and 31P magnetic r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91205-s
更新日期：1992-07-10 00:00:00
abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01463-7
更新日期：1998-03-09 00:00:00
abstract：:There is evidence that acute exposure to kainic acid (KA) induces the release of endogenous ligands for opioid receptors and that mu-opioid agonists intensify KA-induced neurodegeneration. The aim of the present study was to investigate any acute toxic effects of KA upon mu-opioid receptors labelled with [3H]-DAMGO. 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00992-5
更新日期：1998-12-14 00:00:00
abstract：:In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.039
更新日期：2009-06-18 00:00:00
abstract：:Intracisternal injections of hypocretin-1 (hcrt-1) have been shown to elicit sympathoexciatory responses. However, the location of central sites that may mediate these cardiovascular effects have not been clearly elucidated. This study was done in male Wistar rats to investigate the effects of microinjections of hcrt-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.008
更新日期：2003-11-21 00:00:00
abstract：:A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90495-5
更新日期：1979-12-21 00:00:00
abstract：:Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02600-3
更新日期：2003-06-13 00:00:00
abstract：:Iontophoretic injection of cAMP elicits a slow, transient inward current in identified buccal feeding motoneurons and in the giant cerebral interneuron of the snail, Lymnaea stagnalis. The current is voltage independent, and is abolished in the absence of extracellular Na+. Application of the phosphodiesterase inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91330-3
更新日期：1988-01-12 00:00:00
abstract：:To examine the structural interactions between synaptically connected neurons in Aplysia, we have developed a method for simultaneously labeling two identified cell with different and compatible intraneuronal marking agents (horseradish peroxidase and [3H]N-acetyl-D-galactosamine) visible in both the light and electro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90621-8
更新日期：1979-09-14 00:00:00
abstract：:Glucose modulates substantia nigra (SN) dopamine (DA) neuronal activity and GABA axon terminal transmitter release by actions on an ATP-sensitive potassium channel (K(ATP)). Here, the effect of altering SN glucose levels on striatal DA release was assessed by placing microdialysis probes into both the SN and striatum ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02573-7
更新日期：2000-08-25 00:00:00
abstract：:Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90040-i
更新日期：1990-12-17 00:00:00
abstract：:Surgical tissue samples of the human dentate gyrus were immunostained for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA)-synthesizing enzyme, and studied by both light and electron microscopy. Immunoreactive neurons and terminals displayed similar morphological characteristics as known from studies ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91181-4
更新日期：1987-01-13 00:00:00
abstract：:We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90137-4
更新日期：1987-03-01 00:00:00
abstract：:Saccadic adaptation is the progressive correction of systematic saccade targeting errors. When a saccade to a particular target is adapted, saccades within a spatial window around the target, the adaptation field, are affected as a function of their distance from the adapted target. Furthermore, previous studies sugge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.040
更新日期：2007-10-03 00:00:00
abstract：:An expanding body of data has indicated that the seizure prone state in genetically epilepsy-prone rats (GEPRs) is partially caused by deficits in central nervous system noradrenergic transmission. Several lines of evidence suggest that the noradrenergic terminals in the superior colliculus (SC) may act as determinant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01139-6
更新日期：1998-01-12 00:00:00
abstract：:Neuropeptide-Y (NPY) cells in the intergeniculate leaflet (IGL) are known to modulate effects of arousal on the mammalian circadian system. However, the route through which this information reaches the IGL has not been established. Here, we provide evidence that the orexins (hypocretins) are uniquely positioned as a p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.043
更新日期：2005-08-16 00:00:00
abstract：:Regional cerebral blood flow (RCBF) and local cerebral glucose utilization (LCGU) were studied in normal, awake newborn beagle puppies using quantitative autoradiography. A highly significant linear relationship between RCBF and LCGU was present for all brain structures. Special attention was directed to the subependy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90709-1
更新日期：1984-05-14 00:00:00
abstract：:Lithium is detected in the mouse brain with the aid of a (n,alpha) nuclear reaction. The resolving power is of a few micron. The detection efficiency is estimated in a first series of experiments with brain sections of progressively increasing thickness. This allows us to make the microlocation of lithium in the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90239-5
更新日期：1980-10-13 00:00:00
abstract：:The neurosteroid allopregnanolone is a potent and efficacious modulator of gamma-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 micrograms/5 microliters) on basal and stress-induced release of acetylcholine were investigated in various regions o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01478-0
更新日期：1996-02-26 00:00:00
abstract：:The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.003
更新日期：2011-09-09 00:00:00
abstract：:Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.009
更新日期：2006-12-13 00:00:00
abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90350-1
更新日期：1986-05-14 00:00:00
abstract：:Past studies of polymer-encapsulated cell lines implanted in the brain indicated their usefulness for transmitter replacement therapy in animal models. Such grafts may have potentially important clinical applications, but their placement into neural parenchyma may cause a traumatic injury resulting in a leaky blood-br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90929-p
更新日期：1991-06-14 00:00:00
abstract：:The effect of cerebellar stimulation on the accommodation of the lens was examined in anesthetized cats. An infrared optometer was used to measure the refractive power of the lens during stimulation of the cerebellum. The area giving responses within latencies shorter than 160 msec and amplitudes larger than 0.15 diop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90334-7
更新日期：1978-09-29 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91171-c
更新日期：1990-03-26 00:00:00
abstract：:In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.005
更新日期：2009-11-03 00:00:00
abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90510-5
更新日期：1987-11-10 00:00:00
abstract：:The bioelectric activity of the rat superior cervical ganglion (SCG) infected with pseudorabies virus (PRV) was examined in vitro 30-38 h after inoculation. Simultaneous intra- and extracellular recordings on the internal (ICN) and external carotid nerves (ECN) revealed a synchronized spontaneous activity. This synchr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90642-4
更新日期：1982-05-20 00:00:00
abstract：:To study morphological changes in the cortex that follow repeated ischemia, one, two, and three 7-min unilateral occlusions of the carotid artery at 6-h intervals, and three, four, and five 7-min similar occlusions at 12-h intervals were produced in gerbils. Animals with one and two 7-min occlusions at 6-h intervals s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00449-z
更新日期：1995-07-17 00:00:00
