Abstract:
:The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be increased or decreased. We first performed immunohistochemical characterization of the subZI and found neurons and/or fibers in this area positive for melanin concentrating hormone, oxytocin, arginine vasopressin, agouti-related protein and alpha-melanocyte stimulating hormone. Functional characterization of the subZI was tested via site-specific microinjections. The MC3/4-R agonist, melanotan II [MTII (0.025, 0.05 and 0.075nmol)], and specific MC4-R agonist (cyclo [ß-Ala-His-D-Phe-Arg-Trp-Glu]-NH2; 0.024nmol) both significantly increased IBAT temperature (T(IBAT)) and pretreatment with the MC4R antagonist, HS024 (0.072nmol) blocked the MC4-R agonist-induced increased T(IBAT) in conscious, freely-moving Siberian hamsters. Injection of the MC4-R antagonist alone significantly decreased T(IBAT) up to 3h post injection. Collectively, these results highlight the identification of a brain area that possesses high concentrations of MC4-R mRNA and SNS outflow neurons to IBAT that has not been previously reported to be involved in the control of T(IBAT). These results add to previously identified neural nodes that are components of the central circuits controlling thermogenesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Vaughan CH,Shrestha YB,Bartness TJdoi
10.1016/j.brainres.2011.07.003subject
Has Abstractpub_date
2011-09-09 00:00:00pages
17-27eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01242-Xjournal_volume
1411pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.062
更新日期:2004-10-22 00:00:00
abstract::The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91231-x
更新日期:1986-10-01 00:00:00
abstract::The ability of midbrain raphe (MR) cells grafted into serotonin-depleted brain to restore hippocampal responses to synaptically released serotonin was studied using a serotonin-releasing drug, D-fenfluramine (FFA). In normal rats, FFA enhances reactivity of the dentate gyrus (DG) to perforant-path stimulation, while s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91517-k
更新日期:1990-06-25 00:00:00
abstract::The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with no change in input resistance or resting membrane pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90098-4
更新日期:1988-07-12 00:00:00
abstract::Cerebrovascular carbon dioxide (CO2) reactivity is an important hemodynamic index in cerebrovascular disease. In the present study T2*-weighted magnetic resonance image (T2* WI) was evaluated as a non-invasive method to investigate changes in CO2 reactivity. Fourteen rats were subjected to permanent or, 30 and 90 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/S0006-8993(96)01079-7
更新日期:1997-01-09 00:00:00
abstract::Brain microdialysis and high-performance liquid chromatography with electrochemical detection were utilized to study the effect of the selective non-competitive NMDA antagonist MK-801 (dizocilpine) on striatal dopamine (DA) release in the anesthetized rat. Perfusion of 100 microM and 300 microM (+/-)-MK-801 through th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91828-7
更新日期:1994-03-28 00:00:00
abstract::Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.076
更新日期:2007-02-16 00:00:00
abstract::Previous observations show that neonatal removal of nerve growth factor results in an increased number of fine dorsal root axons in the adult animal. The present study shows that the same treatment results in 49% more axons in the adult tract of Lissauer, which is an area of spinal white matter that contains predomina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90262-4
更新日期:1988-10-04 00:00:00
abstract::We have previously demonstrated an absence of ovarian steroid negative feedback on pulsatile luteinizing hormone (LH) release between estrus and early diestrus 1 (D1) in the rat estrous cycle. The object of the present study was to determine if there was a steroid-independent endogenous opioid peptide (EOP) suppressio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90902-4
更新日期:1987-07-28 00:00:00
abstract::Ia synapses in laminae VI and IX of the cat's spinal cord were examined in the electron microscope following iontophoretic injection of horseradish peroxidase (HRP) into single, identified, Ia afferent fibers from gastrocnemius muscles. Ia boutons contacting motoneuron dendrites in lamina IX contained spherical synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90831-x
更新日期:1984-05-23 00:00:00
abstract::This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90938-3
更新日期:1987-10-06 00:00:00
abstract::The present study was carried out in order to determine whether angiotensin II (ANG II) exerts its stimulatory effect on plasma concentration of arginine vasopressin (AVP) and adrenocorticotrophic hormone (ACTH) by interacting with a (gamma-aminobutyric acid) GABAergic pathway. For this purpose, the effect of the GABA...
journal_title:Brain research
pub_type: 临床试验,杂志文章
doi:10.1016/0006-8993(89)90100-5
更新日期:1989-07-03 00:00:00
abstract::Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91521-1
更新日期:1988-03-01 00:00:00
abstract::This report examines the effect of decreasing serum osmolality on movement into the ventricular system of fluid and of test material injected into the brain. Trace quantities of 22NaCl and 125I-labeled cat serum albumin (CSA) were injected into cerebral white matter of cats. The rates of cerebrospinal fluid volume flo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90885-5
更新日期:1978-08-04 00:00:00
abstract::Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90371-h
更新日期:1990-12-24 00:00:00
abstract::Alteration in the blood-nerve barrier may be of primary importance in the development of experimental lead neuropathy. Using quantitative track autoradiography, we have directly demonstrated that there is a 15-fold increase in the rate of 210Pb accumulation in the endoneurium 70 days after the onset of chronic intoxic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90318-8
更新日期:1981-11-23 00:00:00
abstract::Androgens are involved in a variety of centrally mediated functions after binding to their intracellular receptors. In the present report, we have employed the androgen receptor antibody, PG-21, and indirect immunohistochemistry to examine the distribution of cells containing androgen receptor-like immunoreactivity (A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00983-3
更新日期:1995-12-12 00:00:00
abstract::Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03243-2
更新日期:2002-11-08 00:00:00
abstract::Intracellular recordings and labelings with horseradish peroxidase (HRP) of expiratory (E) neurons were performed in decerebrate, paralyzed, and ventilated rats. A total of 37 neurons were recorded, from which 4 cells and 1 axon were labeled. They were located in two regions of the ventrolateral medulla. One was in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90687-5
更新日期:1992-04-03 00:00:00
abstract::Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (+/-)-SKF 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol) [DA D1-like]; bromocriptine, [DA D2 selective]; quinpirole, [DA D2/D3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-OH-DPAT), [DA D3/D2 preferr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01395-5
更新日期:1999-06-05 00:00:00
abstract::Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90695-4
更新日期:1984-10-29 00:00:00
abstract::Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90773-0
更新日期:1994-12-15 00:00:00
abstract::Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90838-1
更新日期:1982-05-06 00:00:00
abstract::When observing bistable stimuli, the percept can change in the absence of changes in the stimulus itself. When intermittently presenting a bistable stimulus, the number of perceptual alternations can increase or decrease, depending on the duration of the period that the stimulus is removed from screen between stimulus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.078
更新日期:2009-02-03 00:00:00
abstract::The organization of globus pallidus (GP) projections was studied in cats using autoradiographic and horseradish peroxidase (HRP) techniques. Both methods confirmed the existence of a topographically organized projection to subthalamic nucleus (STN). Although all but the most caudal GP projects to STN, the heaviest pro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90003-7
更新日期:1980-05-05 00:00:00
abstract::Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90715-7
更新日期:1984-05-14 00:00:00
abstract::Temperature dysregulation is well known in generalized convulsive status epilepticus but so far has not been reported in non-convulsive forms. In order to detect possible subtle alterations, we have analyzed the capability to compensate for external cooling in an animal model of limbic status epilepticus. Rats with el...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.034
更新日期:2007-01-05 00:00:00
abstract::The influence of the superficial layers of the superior colliculus (SC) on responses of the lateral geniculate nucleus was studied in anesthetized and paralyzed rabbits. Fifty to one hundred nanoliters of inactivating drugs were injected through a micropipette positioned in the SC in register with the geniculate cells...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90959-5
更新日期:1986-06-04 00:00:00
abstract::To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91044-8
更新日期:1984-03-05 00:00:00
abstract::The behavioural response following infusion of a novel, stable substance P (SP) analogue, DiMe-C7, into the ventral tegmental area (VTA) of rats was characterized and contrasted with the response to an equal dose of the parent compound SP. DiMe-C7 produced a longer-lasting behavioural stimulation than SP as evidenced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90777-6
更新日期:1982-04-22 00:00:00