Abstract：
:This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration evoked changes in blood pressure and heart rate. The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex. Capsaicin evoked dose-dependent hypotension and bradycardia at the same sites. These results further support the possibility that SP may be a neurotransmitter or neuromodulator of baroreceptor afferents in the NTS.
journal_name
Brain Resjournal_title
Brain researchauthors
Lukovic L,de Jong W,de Wied Ddoi
10.1016/0006-8993(87)90938-3subject
Has Abstractpub_date
1987-10-06 00:00:00pages
312-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90938-3journal_volume
422pub_type
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