Calcium dependency of excitatory chemical synaptic transmission in the frog cerebellum in vitro.

Abstract:

:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) current injections. Evoked synaptic transmission at both junctions was reduced by lowering the extracellular concentration of calcium ions ([Ca2+]) below 2 mM. Raising [Ca2+] above 2 mM to 8 mM did not further increase synaptic transmission. Mg2+, Sr2+, and Ba2+ did not substitute for Ca2+ in the transmission process.

journal_name

Brain Res

journal_title

Brain research

authors

Hackett JT

doi

10.1016/0006-8993(76)91005-2

subject

Has Abstract

pub_date

1976-09-10 00:00:00

pages

35-46

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(76)91005-2

journal_volume

114

pub_type

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