Abstract:
:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) current injections. Evoked synaptic transmission at both junctions was reduced by lowering the extracellular concentration of calcium ions ([Ca2+]) below 2 mM. Raising [Ca2+] above 2 mM to 8 mM did not further increase synaptic transmission. Mg2+, Sr2+, and Ba2+ did not substitute for Ca2+ in the transmission process.
journal_name
Brain Resjournal_title
Brain researchauthors
Hackett JTdoi
10.1016/0006-8993(76)91005-2subject
Has Abstractpub_date
1976-09-10 00:00:00pages
35-46issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(76)91005-2journal_volume
114pub_type
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