Abstract：
:The effect of maternal hyperthermia on the developmental state of newborn guinea pig brains has been studied. Mean litter size and mean body weights of young from control and experimental mothers did not differ. Mean brain weight of young from control mothers (2.72 +/- 0.02 g) was larger than that from experimental mothers (2.3 +/- 0.03 g). This reduced brain weight was expressed in terms of body weight and showed a mean deficit of 16.4 +/- 1% (range 3.4 to 36.1%). A good correlation was observed between the degree of microencephaly and brain DNA content in experimental young, and the mean reduction in DNA level was 14.9% which compares well with the mean weight reduction. Data from dissected brains indicate that much of the reduction in brain weight and DNA content observed following maternal hyperthermia was owing to an effect on the cerebral hemisphere. Specific activities of synaptic and microsomal membrane marker enzymes were similar in preparations from control and microencephalic young. However, the activities of the enzymes, when expressed in terms of DNA content, were higher in cerebral preparations from microencephalic young as compared with controls. Microencephaly is associated with a reduced cell number (DNA content) but a compensatory elaboration of neuronal dendritic processes also seems to occur.
journal_name
Brain Resjournal_title
Brain researchauthors
Hutchinson R,Bowler Kdoi
10.1016/0165-3806(84)90306-7subject
Has Abstractpub_date
1984-06-01 00:00:00pages
219-27issue
2eissn
0006-8993issn
1872-6240journal_volume
316pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91560-2
更新日期：1992-11-20 00:00:00
abstract：:Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury is neuroprotective in animal models. Recent studies have demonstrated that animals housed in an enriched environment condition after an experimental stroke obtained a better functional outcome than those ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.036
更新日期：2013-11-13 00:00:00
abstract：:The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor antagonist) on alcohol intake by C57BL/6 mice in a restricted access paradigm were examined. During the pretreatment baseline phase, mice consumed an average of 1.3 g/...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90672-a
更新日期：1993-12-10 00:00:00
abstract：:The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90958-x
更新日期：1991-06-14 00:00:00
abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90800-o
更新日期：1992-03-06 00:00:00
abstract：:Long-term memory formation for passive-avoidance learning in the day-old chick is known to have two distinct time windows of protein synthesis (F.M. Freeman, S.P.R. Rose, A.B. Scholey, 1995. Two time windows of anisomycin-induced amnesia for passive-avoidance training in the day-old chick. Neurobiol. Learn. Mem. 63, 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02181-8
更新日期：2000-05-12 00:00:00
abstract：:The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.081
更新日期：2010-02-08 00:00:00
abstract：:Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.034
更新日期：2013-01-25 00:00:00
abstract：:Rats were exposed to 1.3 gHz microwave energy to assess the uptake of several neutral polar substances in certain areas of the brain. A quantitative, radioactive isotope method, which uses an internal standard, was employed to measure the loss of test substances to brain tissue. Single, 20 min exposure, to either puls...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90726-0
更新日期：1977-05-06 00:00:00
abstract：:Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90901-0
更新日期：1983-10-24 00:00:00
abstract：:The binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled and 'yoked' control rat brains was evaluated in subjects sacrificed 60 days after the sixth generalized convulsion. Decreases in the Bmax for [3H]flunitrazepam binding to 'central-type' benzodiazepine receptors were observed in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90210-x
更新日期：1983-11-21 00:00:00
abstract：:Regional cerebral blood flow (RCBF) and local cerebral glucose utilization (LCGU) were studied in normal, awake newborn beagle puppies using quantitative autoradiography. A highly significant linear relationship between RCBF and LCGU was present for all brain structures. Special attention was directed to the subependy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90709-1
更新日期：1984-05-14 00:00:00
abstract：:Anesthetized Sprague-Dawley rats fitted with intracerebroventricular (i.c.v.) cannulas were infused with one of the aminopeptidase inhibitors, amastatin or bestatin, over a 5-min period. After infusion, 1-2 X 10(6) cpm of [125I]angiotensin II ([125I]AII) or [125I]angiotensin III ([125I]AIII) was injected through the s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91279-6
更新日期：1988-05-17 00:00:00
abstract：:Single motor unit activity was recorded from human lower lip muscles while subjects maintained a firing rate of 20 ips using audio and visual feedback. Each motor unit was classified as belonging to one of three muscles, orbicularis oris inferior (OOI), mentalis (MENT), or depressor labii inferior (DLI). Reflex respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91274-4
更新日期：1982-11-11 00:00:00
abstract：:Discrete axon-sparing lesions were placed unilaterally in the mesencephalon by the local injection of kainic acid. Unilateral lesions of the dorsal reticular formation just beneath the superior colliculus and lateral to the periacqueductal grey resulted in consistent ipsiversive apomorphine-induced circling. Only weak...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90579-5
更新日期：1981-03-16 00:00:00
abstract：:The glutaminase activity in rat and guinea pig retina is twice as high in photoreceptor inner segments as in any other layer. Since the inner segments are involved in non-transmitter-related metabolic functions, it is suggested that glutaminase should not necessarily be taken to imply glutamatergic neurotransmission u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91178-4
更新日期：1987-01-13 00:00:00
abstract：:Whole-cell patch recordings of neurons in the rostral (gustatory) nucleus tractus solitarius (rNTS) were performed in a brain slice preparation from rat medulla. Neural responses to brief applications (10-45 s) of substance P (SP), via a constant superfusion apparatus, were recorded. SP transiently depolarized 80 of 1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91603-p
更新日期：1993-08-13 00:00:00
abstract：:To clarify the effects of arachidonic acid (AA) and its metabolites on desensitization of nicotinic acetylcholine (ACh) receptor channel in mouse skeletal muscle cells, we investigated the time-dependent decrease in the channel opening frequency of ACh (1 microM)-activated channel currents by the cell-attached patch c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02206-4
更新日期：2000-01-03 00:00:00
abstract：:Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90166-5
更新日期：1984-09-24 00:00:00
abstract：:Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A lin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00708-1
更新日期：1996-08-26 00:00:00
abstract：:The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90341-9
更新日期：1977-12-02 00:00:00
abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90992-8
更新日期：1985-12-09 00:00:00
abstract：:To characterize properties and mechanisms of non-photic entrainment of circadian rhythms, the effects of scheduled feeding were assessed in intact and suprachiasmatic nuclei (SCN) ablated C57BL/6j mice. During ad libitum food access, mice with no or partial SCN damage exhibited free-running activity and drinking rhyth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00571-4
更新日期：1997-08-15 00:00:00
abstract：:Using an immunoperoxidase technique, somatostatin-28-like immunoreactive (LIR) neurons were observed in the main and accessory olfactory bulb (MOB and AOB) of adult rats. In the MOB, a restricted population of periglomerular cells in the glomerular layer, some superficial short-axon cells in the juxtaglomerular layer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91242-9
更新日期：1990-09-03 00:00:00
abstract：:Our previous single unit and ultrastructural studies of visual cortex of dark-reared rats revealed an impairment of intracortical inhibitory mechanisms [2,3,5]. Neurochemical changes in inhibitory neurotransmitter and/or neuropeptides, such as gamma-aminobutyric acid (GABA) and somatostatin (SS), respectively, may con...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00553-3
更新日期：1995-08-21 00:00:00
abstract：:The cell-mediated inflammatory component of experimental autoimmune encephalomyelitis (EAE) in mice is measured by the radioisotopic technique. Mice are challenged with autologous spinal cord homogenate in Freund's complete adjuvant and at various time intervals after such immunization given [125I]5-iodo-2'-deoxyuridi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90850-3
更新日期：1979-10-05 00:00:00
abstract：:Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00797-t
更新日期：1995-10-30 00:00:00
abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00706-v
更新日期：1995-10-09 00:00:00
abstract：:Primary gaze fixation in healthy individuals is frequently interrupted by microsaccades and saccadic intrusions (SI). The neural systems responsible for the control of attention and eye movements are believed to overlap and in line with this, the behaviour of microsaccades appears to be affected by exogenous and endog...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.047
更新日期：2007-04-13 00:00:00
abstract：:In vivo release of labeled serotonin ([3H]5-HT) from the parietal cortex was investigated by cortical cup technique and electrical stimulation of midbrain raphe in rats anesthetized with pentobarbital sodium. The spontaneous efflux of tritium from the parietal cortex preload with [3H]5-HT followed a multiphasic expone...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90137-2
更新日期：1981-07-20 00:00:00
