Abstract：
:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary acidic protein (GFAP). In some rats, vehicle was injected into the nbM and in others 6-hydroxydopamine (6-OHDA) was injected into the ventral tegmental area (VTA). Quantitative Western blot analysis revealed significantly greater immunoreactivity for GFAP in the prefrontal cortex of nbM-lesioned rats. Immunohistochemical examination revealed fibrous and hypertrophic GFAP-positive astrocytes even one day after surgery, and this reaction was stronger at 3 days after surgery. After this peak, GFAP-immunoreactivity of the astrocytes decreased from 7 days to 21 days. In contrast, GFAP-positive astrocytes were not observed in the brains of vehicle-injected or VTA-lesioned rats, even 21 days after surgery. The present results indicate that cortical astrocytes respond to cholinergic deafferentation. In addition, our findings provide new insights into the abnormalities of cortical glial cells after cholinergic deafferentation in Alzheimer's disease.
journal_name
Brain Resjournal_title
Brain researchauthors
Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake Tdoi
10.1016/0006-8993(92)90800-osubject
Has Abstractpub_date
1992-03-06 00:00:00pages
63-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90800-Ojournal_volume
574pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Within the bullfrog semicircular canal crista, hair cell tuft types were defined and mapped with the aid of scanning electron microscopy. Intracellular recording and Lucifer Yellow labeling techniques were used to study afferent responses and arborization patterns. Dye-filled planar afferent axons had mean distal axon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90107-m
更新日期：1990-11-26 00:00:00
abstract：:Many of the behavioral consequences of dopamine system activation are thought to be mediated by substantia nigra pars reticulata output pathways. Extracellular, single unit recording studies were conducted to determine how i.v. administration of the dopamine agonist, apomorphine, affects the activity of these pars ret...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90380-9
更新日期：1984-07-23 00:00:00
abstract：:Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage. Since kainate increases the release of excitatory amino acid neurotransmitters such as glutamate, this synd...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90227-5
更新日期：1994-08-01 00:00:00
abstract：:Increases in extracellular potassium concentrations reliably increase burst rates in cultured fetal murine spinal cord networks. This effect could be mimicked by either blocking voltage-gated potassium conductances or facilitating excitatory synaptic interactions, but not by blocking specific calcium-dependent potassi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90039-6
更新日期：1994-04-18 00:00:00
abstract：:The possible involvement of protein kinase A (PKA) in the muscarinic inhibition of the slow afterhyperpolarizing current (IAHP) was investigated in rat hippocampal pyramidal cells. IAHP was recorded using the whole cell method in hippocampal slices, and Rp-cAMPS, a PKA antagonist, was applied intracellularly. The inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90096-5
更新日期：1994-05-23 00:00:00
abstract：:The present work evaluated the reproducibility and variance of the cerebral blood flow (CBF) response to natural whisker stimulation in the barrel cortex of awake behaving mice. The animal was placed on an air float ball that allowed the animal to walk, while the head of the animal was fixed in a custom-made stereotac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.007
更新日期：2011-01-19 00:00:00
abstract：:Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.049
更新日期：2009-06-01 00:00:00
abstract：:Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90698-9
更新日期：1982-12-16 00:00:00
abstract：:Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01260-o
更新日期：1995-01-09 00:00:00
abstract：:The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.065
更新日期：2007-08-13 00:00:00
abstract：:Interactive-activation models posit that visual word recognition involves co-activation of orthographic neighbors (e.g., note, node) and competition among them via lateral inhibitory connections. Behavioral evidence of this lexical competition comes from masked priming paradigms, in which target words elicit slower re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.029
更新日期：2018-04-15 00:00:00
abstract：:While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.023
更新日期：2006-10-30 00:00:00
abstract：:Biocytin is useful for intracellular filling in living slices because it is soluble, has high electrophoretic mobility and a high affinity for avidin. In fixed slices, however, membrane potential cannot be used to signify that a cell is impaled. Thus, it is necessary to inject a fluorescent molecule so that impalement...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90776-j
更新日期：1993-04-09 00:00:00
abstract：:Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01422-e
更新日期：1995-03-06 00:00:00
abstract：:We cloned the genes for the mouse homologue of the neuromedin B receptor (NMB-R) and the bombesin receptor subtype 3 (BRS-3). Both receptor genes consist of three exons with well-conserved intron-exon borders. Although the NMB-R gene spans more than 10 kb, the BRS-3 gene spans only about 4 kb. Comparison of the mouse ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00380-6
更新日期：1997-07-11 00:00:00
abstract：:The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.07.034
更新日期：2015-12-02 00:00:00
abstract：:Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.086
更新日期：2010-08-06 00:00:00
abstract：:Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. This suggests that glucocorticoid availability in the ventral hippocampus during stress may be reduced during am...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.05.030
更新日期：2016-08-01 00:00:00
abstract：:Using quantitative receptor radioautography, binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 were studied in rats 4 week after end-to-side portacaval anastomosis and in sham-operated controls. Portacaval anastomosis resulted in region-selective increases in density of [3H]PK 11195 b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91222-z
更新日期：1992-07-10 00:00:00
abstract：:Partial, unilateral olfactory nerve section was performed in mice, and the behavior of the olfactory marker protein (OMP) studied, after this experimental manipulation, with the peroxidase--antiperoxidase method. The protein, which in normal mice is present only in mature olfactory sensory neurons, after unilateral le...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90162-1
更新日期：1981-03-30 00:00:00
abstract：:Male laboratory rats were raised in two colonies, each of 27 rats, and then given intraventricular injections of the norepinephrine neurotoxin 6-hydroxydopamine (6-OHDA) or the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or saline. They were then returned to their enclosure and behavior during the next 50 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90688-0
更新日期：1976-02-13 00:00:00
abstract：:Hybridization histochemical and immunohistochemical methods were used to characterize the distribution of corticotropin-releasing factor (CRF) messenger RNA (mRNA) and peptide, respectively, in the central auditory system of the rat. Cell bodies expressing CRF mRNA and/or immunoreactivity (IR) were detected at each le...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90571-c
更新日期：1991-04-26 00:00:00
abstract：:The effects of 17beta-estradiol (17betaE2) on spontaneous and excitatory amino acid (EAA) induced nucleus tractus solitarius (NTS) neuronal activity were investigated by electrophysiological and immunohistochemical experiments in ovariectomized female Sprague-Dawley rats. Out of 62 NTS neurons tested, 42 were inhibite...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02629-5
更新日期：2003-06-20 00:00:00
abstract：:After a moderate global cerebral ischemia, two hypothetical populations of pyramidal neurons are present among the hippocampal CA1 pyramidal neurons: one that will die and another one that will survive. Prior analysis of dissected hippocampal CA1 regions has shown a reduction of the GluR1-3 mRNA following ischemia. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)01985-0
更新日期：2001-03-09 00:00:00
abstract：:Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90499-2
更新日期：1984-07-30 00:00:00
abstract：:Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.074
更新日期：2005-07-05 00:00:00
abstract：:The N400 is an event-related potential (ERP) component that is elicited by semantically meaningful stimuli; one of its defining characteristics is that it is amplified for sentence completions that are semantically unexpected or incongruous with the preceding context. Some prior reports using visual sentence reading p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.099
更新日期：2010-10-08 00:00:00
abstract：:Leukocyte behavior in the cerebral microvasculature following vessel occlusion has not been fully elucidated. The purpose of this study was to investigate the effects of cilostazol on leukocyte behavior (rolling and adhesion) in murine cerebral microvessels following transient bilateral carotid artery occlusion using ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.11.017
更新日期：2014-01-16 00:00:00
abstract：:Nitric oxide (NO) is a neuronal messenger that it is thought to be involved in the nociceptive transmission modulation. The activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) was shown to be identical to NOS activity in the brain. Since the periaqueductal gray matter (PAG) plays an important ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00255-8
更新日期：1998-05-18 00:00:00
abstract：:Here we describe a sustained outward potassium current (IK) in retinal horizontal cells (HCs). IK is unusually small over the range of membrane potentials normally experienced by these cells, which are chronically depolarized. We hypothesize that this unique IK will reduce the amount of neurotransmitter required to sh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90204-o
更新日期：1990-09-24 00:00:00
