Abstract：
:Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memory ('knowing that' a particular maze location contains food) while leaving procedural memory intact ('knowing how' to search for food in the maze). This specific memory impairment was prevented by pretreatment with the opiate antagonist naloxone. Naloxone also improved memory performance when given to non-stimulated subjects.
journal_name
Brain Resjournal_title
Brain researchauthors
Collier TJ,Routtenberg Adoi
10.1016/0006-8993(84)90166-5subject
Has Abstractpub_date
1984-09-24 00:00:00pages
384-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90166-5journal_volume
310pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The periodicity of the myelin sheath in glutaraldehyde carbohydrazide (GACH) embedded tissues from three 10-day-old and two 43-day-old mice was investigated with the electron microscope. The mean repeat period and number of repeats per fiber was measured in 31-89 fibers in the trapezoid bodies, olfactory tract and sci...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90051-2
更新日期：1976-09-03 00:00:00
abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.022
更新日期：2009-02-23 00:00:00
abstract：:An immunohistochemical investigation of the bovine pineal gland was performed using both a rabbit polyclonal antibody and a rat monoclonal antibody against choline acetyltransferase (ChAT). A network of ChAT-immunoreactive (IR) nerve fibers was located throughout the pineal gland, both in the perivascular spaces and b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91268-6
更新日期：1991-04-05 00:00:00
abstract：:The purpose of the present study is to examine the effects of mental fatigue and motivation on neural network dynamics activated during task switching. Mental fatigue was induced by 2 h of continuous performance; after which subjects were motivated by using social comparison and monetary reward as motivating factors t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.015
更新日期：2009-05-13 00:00:00
abstract：:The sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. Four sham-lesioned males served as controls. Lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90405-2
更新日期：1988-11-01 00:00:00
abstract：:Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90001-9
更新日期：1983-06-01 00:00:00
abstract：:Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91800-7
更新日期：1994-07-11 00:00:00
abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.018
更新日期：2014-10-02 00:00:00
abstract：:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91557-0
更新日期：1988-05-31 00:00:00
abstract：:The neurotoxic effects of chronic ethanol exposure were investigated in rat hippocampus by electrophysiological analysis of the Schaffer collateral-commissural input to stratum radiatum of CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special diet at leas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90777-0
更新日期：1981-09-28 00:00:00
abstract：:By utilizing the microinjection of low nanoliter volumes of convulsant drug and recording from the injection site, we have been able to electrophysiologically identify a layer of cat striate cortex that is most sensitive to the epileptogenic effects of penicillin. This band encompasses cortical depths of approximately...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91084-8
更新日期：1982-06-10 00:00:00
abstract：:Within the framework of the dual process model of recognition memory, prior work with event-related potentials (ERPs) has suggested that an early component, the FN400, is a correlate of familiarity while a later component, the Late Positive Complex (LPC), is a correlate of recollection. However, other work has questio...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2006.04.050
更新日期：2006-06-22 00:00:00
abstract：:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01466-3
更新日期：1999-06-19 00:00:00
abstract：:The focal ischemia obtained in an animal model of middle cerebral artery occlusion (MCAo) causes the "core" of damage in the striatum and the "penumbra" of damage in the fronto-parietal cortex. The latter is mainly functionally affected and shows changes in nNOS and iNOS expression during the acute phase of ischemia. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.029
更新日期：2007-02-09 00:00:00
abstract：:In alert cats, extracellular spikes of neurons in the medial pontine tegmentum were recorded simultaneously with whole nerve discharges of the abducens and medial rectus nerves during horizontal vestibular nystagmus. Nystagmus-related neurons were classified by their firing patterns in relation to the abrupt cessation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90941-0
更新日期：1981-10-05 00:00:00
abstract：:The effect of central and peripheral administration of a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on morphine hyperthermia was studied in male Sprague-Dawley rats. The first series of experiments examined the effect of subcutaneous (s.c.) administration of L-NAME on the hyperthermia i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02025-x
更新日期：2001-03-16 00:00:00
abstract：:A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03048-1
更新日期：2001-01-19 00:00:00
abstract：:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90374-4
更新日期：1986-04-23 00:00:00
abstract：:Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well known and popular herbal medicine used worldwide. Among more than 30 ginsenosides, the active ingredients of ginseng, ginsenosides Rb1 and Rg1 are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. In our study, p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.030
更新日期：2004-09-17 00:00:00
abstract：:The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91237-8
更新日期：1994-02-21 00:00:00
abstract：:Frequency-modulated (FM) sweeps are important components of most natural sounds. To examine the processing of these stimuli we applied a two-tone paradigm. Repeated stimulus presentation usually leads to reduced neuronal responses. However, in a former study repetition enhancements which have been observed when FM ton...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.009
更新日期：2011-09-09 00:00:00
abstract：:The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00923-2
更新日期：1997-11-14 00:00:00
abstract：:Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90016-5
更新日期：1990-12-17 00:00:00
abstract：:Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90184-6
更新日期：1984-01-01 00:00:00
abstract：:The contribution of neurons in the nucleus medianus (NM) in mediating the drinking and pressor responses elicited by administration of angiotensin II (AII) either directly into the subfornical organ (SFO) or intravenously was investigated in conscious, unrestrained rats. Microinjection of AII into the SFO elicited a r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90692-6
更新日期：1989-05-29 00:00:00
abstract：:Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.006
更新日期：2015-11-02 00:00:00
abstract：:The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146879
更新日期：2020-08-15 00:00:00
abstract：:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04045-3
更新日期：2003-02-14 00:00:00
abstract：:It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00191-1
更新日期：1997-05-02 00:00:00
abstract：:Possible synergistic effects of the glucocorticoid dexamethasone (DEX, 10(-7) M) and the adenylate cyclase agonist forskolin (FSK, 10(-5) M) on [Met5]enkephalin (ME) accumulation were examined in enriched rat glial cultures and in mixed neuronal/glial cultures. In enriched glial cultures, DEX and FSK each stimulated t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00443-x
更新日期：1996-08-19 00:00:00
