Abstract：
:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral artery (MCA). Infarct volume was measured at 48 h after the injury. Administration of minocycline alone or minocycline plus mild hypothermia reduced infarct volume significantly. However, mild hypothermia in combination with minocycline did not show any additive effect. These results suggest that minocycline is beneficial in focal ischemic brain injury, and the lack of the enhanced neuroprotection may be due to the brief exposure to hypothermia.
journal_name
Brain Resjournal_title
Brain researchauthors
Wang CX,Yang T,Shuaib Adoi
10.1016/s0006-8993(02)04045-3subject
Has Abstractpub_date
2003-02-14 00:00:00pages
327-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302040453journal_volume
963pub_type
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