Abstract：
:Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to local injection of physostigmine, an inhibitor of acetylcholine metabolism. While intrahippocampal physostigmine elicited hippocampal seizure activity in 80% of the animals tested during withdrawal from chronic exposure to low levels of ethanol, seizure activity was elicited in only 30% of ethanol-naive subjects. These results suggest that chronic ethanol exposure may increase the sensitivity of hippocampal neurons to cholinergic stimulation, and that some of the symptoms of ethanol withdrawal may be related to this change.
journal_name
Brain Resjournal_title
Brain researchauthors
Gonzalez LPdoi
10.1016/0006-8993(85)90500-1subject
Has Abstractpub_date
1985-06-03 00:00:00pages
384-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90500-1journal_volume
335pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91245-n
更新日期：1993-02-19 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:The blood-brain barrier consists of the cerebral microvascular endothelium, pericytes, astrocytes, and neurons. In this study, we analyzed the influence of primary porcine brain capillary pericytes on the barrier integrity of primary porcine brain capillary endothelial cells in a species-consistent in vitro coculture ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.096
更新日期：2010-08-06 00:00:00
abstract：:Examination of glycolmethacrylate embedded olfactory bulbs of normal rats revealed that the granule cells of the accessory olfactory bulb were dissimilar from the majority of main olfactory bulb granule cells. Cells from these structures can be discriminated on the basis of spherical form. nuclear diameter, nucleoplas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90711-9
更新日期：1982-03-25 00:00:00
abstract：:Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used to investigate the actions of drugs of abuse. However, few studies have examined both paradigms in the same group of animals. We were interested in developing a combined protocol which successfully induced both conditio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.054
更新日期：2008-06-05 00:00:00
abstract：:Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91185-1
更新日期：1994-10-24 00:00:00
abstract：:The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and D-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) bu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90840-2
更新日期：1988-06-28 00:00:00
abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90510-5
更新日期：1987-11-10 00:00:00
abstract：:Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91212-7
更新日期：1988-09-13 00:00:00
abstract：:Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90023-0
更新日期：1987-06-30 00:00:00
abstract：:The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90287-2
更新日期：1985-05-27 00:00:00
abstract：:The effects of intracerebroventricular (i.c.v.) infusion of arginine vasopressin (AVP) on intracranial pressure (ICP), blood pressure (BP) and plasma AVP were investigated in conscious goats. The animals were implanted with ventricular (V) and cisternal (C) cannulae under halothane anaesthesia and allowed to recover p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90850-x
更新日期：1987-10-13 00:00:00
abstract：:Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90076-7
更新日期：1981-04-27 00:00:00
abstract：:To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90713-6
更新日期：1991-08-30 00:00:00
abstract：:We monitored biosynthetic activity of optic tract glia during regeneration of retinal ganglion cell axons in the goldfish and found that the greatest level of incorporated [3H]thymidine and [3H]leucine occurred in glia by 10-15 days after axotomy. During this period there was a marked increase in the number of oligode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90624-9
更新日期：1985-07-22 00:00:00
abstract：:The olfactory sensory neurons are unique in the vertebrate nervous system in that they are replaced following experimentally induced degeneration. Unilateral removal of the olfactory bulb in hamster results in degeneration of all mature receptor neurons followed by a neurogenesis and partial replacement of the recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90483-9
更新日期：1984-07-30 00:00:00
abstract：:Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90195-1
更新日期：1979-01-26 00:00:00
abstract：:Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90951-9
更新日期：1982-10-28 00:00:00
abstract：:Monkeys were trained to depress a hold key for a period of 2 sec. After this hold period, either a red or a green cue lamp appeared in random sequence. The red lamp required the monkey to move his hand from the hold key to a target button within 1 sec of the cue presentation. The green lamp required continued depressi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90986-0
更新日期：1976-01-09 00:00:00
abstract：:Attachment, growth and morphological differentiation of isolated adult rat oligodendrocytes cultured on a naturally produced basement membrane-like extracellular matrix (ECM) occurred much faster than on poly-L-lysine (PLL) coated tissue culture dishes. In each individual trial the cells cultured on ECM exhibited, wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91049-1
更新日期：1983-05-09 00:00:00
abstract：:The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90073-2
更新日期：1985-09-01 00:00:00
abstract：:The properties of 5 beta-reductase, 5 alpha-reductase and aromatase, 3 testosterone metabolizing enzymes, were studied in the quail brain by an in vitro incubation technique. The results describe the changes in time of metabolite production and the effects of temperature, enzyme and cofactor concentrations. The appare...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91118-1
更新日期：1984-07-02 00:00:00
abstract：:Retrogradely labeled neurons are observed in the central nervous system of the toad after peripheral application of peroxidase to the anterior and posterior stumps of the VIIIth nerve. These efferent vestibular neurons are localized in the brainstem only ipsilaterally to the treated nerve; they are restricted within a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91183-7
更新日期：1985-09-30 00:00:00
abstract：:Nitric oxide (NO) production in the sensory neurons of the rad nodose ganglion was studied by examining the distribuiotn of NO synthase (NOS) by use of NADPH diaphorase (NADPHD) histochemistry and immunohistochemistry ofr the presence of isoformes of NOS: neuronal (nNOS), endothelial (eNOS) and the inducible isoform (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03826-x
更新日期：2003-01-24 00:00:00
abstract：:In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02382-4
更新日期：2001-05-25 00:00:00
abstract：:This study investigated the effects of N6-cyclopentyladenosine (CPA), a potent and selective adenosine A1 receptor (A1R) agonist in normal and nerve-injured rats and mechanisms of its action by behavioral tests and electrophysiological technique. The results showed: (1) In normal rats, intraperitoneal administration o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.034
更新日期：2010-11-18 00:00:00
abstract：:In humans, tendon vibration evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response, AVR), i.e., in the muscle groups normally contracted if the illusory movement had been performed. The aim of the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02604-4
更新日期：2000-10-27 00:00:00
abstract：:It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and dir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02663-9
更新日期：2000-09-15 00:00:00
abstract：:When nomifensine is employed to inhibit neuronal uptake, exposure to dopamine (DA) (0.1-0.3 microM) or apomorphine (0.01-0.1 microM) inhibited, in a concentration-dependent manner, the electrically evoked release of [3H]dopamine from slices of the rabbit caudate nucleus. Apomorphine inhibited transmitter release indep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91605-1
更新日期：1985-06-24 00:00:00
abstract：:It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90234-m
更新日期：1991-07-05 00:00:00
