Effects of training on saccadic eye movements elicited electrically from the frontal cortex of monkeys.


:It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and direction [7]. The current study re-investigates this finding. Monkeys were trained to produce saccadic eye movements to a visual target. After training, electrical stimulation was delivered to the DMFC. It was found that stimulation of the DMFC always evoked saccadic eye movements of the same size and direction before and after training, such that training had little effect on the responses evoked electrically from the DMFC. Differences between the current results and previous results have disclosed new clues as to how the DMFC might be modulated by learning.


Brain Res


Brain research


Tehovnik EJ,Slocum WM




Has Abstract


2000-09-15 00:00:00














  • A monoclonal antibody to mammalian neurofilament protein stains somata and dendrites in gymnotid fish.

    abstract::Monoclonal antibody N210 (mabN210) recognizes the 210 kdalton neurofilament protein in mammals and gives characteristic immunocytochemical staining of neurofilament-rich processes. For example, in the cerebellum it recognizes myelinated axons and the calyx formed by basket cell axon collaterals. The distribution of ma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maler L,Leclerc N,Hawkes R

    更新日期:1986-07-23 00:00:00

  • Insulin-like 6 immunoreactivity in the mouse brain and testis.

    abstract::Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brailoiu GC,Dun SL,Yin D,Yang J,Chang JK,Dun NJ

    更新日期:2005-04-08 00:00:00

  • Protein phosphatase inhibitors prolong Ca(2+)-transients and divalent cation-dependent action potentials in leech Retzius cells.

    abstract::Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kleinhaus AL,Zeman RJ

    更新日期:1994-07-11 00:00:00

  • Sodium valproate decreases synaptic potentiation and epileptiform activity in hippocampus.

    abstract::The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Griffith WH,Taylor L

    更新日期:1988-11-22 00:00:00

  • Return of ATP/PCr and EEG after 75 min of global brain ischemia.

    abstract::Acute, progressive global brain ischemia was induced in awake or anesthetized rats for 5-75 min. Ischemia was achieved with a subclavian-carotid artery occlusion technique (SCOT). After thoracotomy, both subclavian arteries (proximal to their vertebral branches) were tied-off and carotid artery catheter-snares install...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: de la Torre JC,Saunders J,Fortin T,Butler K,Richard M

    更新日期:1991-02-22 00:00:00

  • Axonal transport in serotonin neurons of the midbrain raphe.

    abstract::The projections of serotonin-containing neurons of the midbrain raphe nuclei (nucleus raphe dorsalis, nucleus centralis superior) are studied by analysis of axonal transport of labeled amino acids. These results are correlated with regional alterations of serotonin content following midbrain raphe lesions which produc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Halaris AE,Jones BE,Moore RY

    更新日期:1976-05-14 00:00:00

  • Disintegration of orthogonal arrays in perivascular astrocytic processes as an early event in acute global ischemia.

    abstract::A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Suzuki M,Iwasaki Y,Yamamoto T,Konno H,Yoshimoto T,Suzuki J

    更新日期:1984-05-21 00:00:00

  • Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section.

    abstract::Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Atkinson L,Shigetomi E,Kato F,Deuchars J

    更新日期:2003-07-04 00:00:00

  • The re-establishment of synaptic transmission by regenerating optic axons in goldfish: time course and effects of blocking activity by intraocular injection of tetrodotoxin.

    abstract::Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmidt JT,Edwards DL,Stuermer C

    更新日期:1983-06-13 00:00:00

  • Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus.

    abstract::We have shown previously that plasmin facilitated the generation of long-term potentiation (LTP) in CA1 and dentate region of rat hippocampus. In the present study, we investigated the effects of plasmin on postsynaptic currents in CA1 pyramidal neurons of rat hippocampal slices. Plasmin (100 nM) had no effect on NMDA...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mizutani A,Tanaka T,Saito H,Matsuki N

    更新日期:1997-06-27 00:00:00

  • Conductance changes and inhibitory actions of hippocampal recurrent IPSPs.

    abstract::Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by sma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dingledine R,Langmoen IA

    更新日期:1980-03-10 00:00:00

  • Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog.

    abstract::We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Szallasi A,Joo F,Blumberg PM

    更新日期:1989-11-27 00:00:00

  • On the mechanism and site of action of enkephalin on single myenteric neurons.

    abstract::Intracellular recordings were made from neurons in the isolated myenteric plexus of the guinea-pig ileum. Methionine- and leucine-enkephalin were applied to the neurons either by adding them to the perfusing solution in known concentrations or be ejecting them by microiontophoresis. When applied in the perfusion solut...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: North RA,Katayama Y,Williams JT

    更新日期:1979-04-06 00:00:00

  • Substrate specificities of the two genetically distinct human brain beta-galactosidases.

    abstract::The two human brain beta-galactosidases were solubilized and fractionated by Sephadex G-200 gel filtration, free from each other. Substrate specificities of the two enzymes were examined for galactosylceramide, lactosyl-[N-stearoyl]ceramide, lactosyl-[N-lignoceroyl]ceramide, galactosyl-N-acetylgalactosaminyl-[N-stearo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tanaka H,Suzuki K

    更新日期:1977-02-18 00:00:00

  • Sites of aromatization of [3H]testosterone in forebrain of male, female and androgen receptor-deficient Tfm mice: an autoradiographic study.

    abstract::The distribution of radioactivity after injection of [3H]testosterone was studied in the forebrain of adult mice by thaw-mount autoradiography. Nuclear labeling was high in neurons in the dorsal part of the medial nucleus of the amygdala and in the dorsocaudal part of the bed nucleus of the stria terminalis. Low nucle...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schleicher G,Stumpf WE,Morin JK,Drews U

    更新日期:1986-11-12 00:00:00

  • Lesions of the cerebellar interpositus nucleus abolish both nictitating membrane and eyelid EMG conditioned responses.

    abstract::Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lavond DG,Logan CG,Sohn JH,Garner WD,Kanzawa SA

    更新日期:1990-04-30 00:00:00

  • A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease.

    abstract::Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrilla...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morrison JH,Lewis DA,Campbell MJ,Huntley GW,Benson DL,Bouras C

    更新日期:1987-07-28 00:00:00

  • Weakening of functional corticomuscular coupling during muscle fatigue.

    abstract:OBJECTIVE:Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yang Q,Fang Y,Sun CK,Siemionow V,Ranganathan VK,Khoshknabi D,Davis MP,Walsh D,Sahgal V,Yue GH

    更新日期:2009-01-23 00:00:00

  • Monosodium glutamate: increased neurotoxicity after removal of neuronal re-uptake sites.

    abstract::Microinjections of monosodium glutamate (MSG; 300 microgram/0.5 microliter) into the hippocampus of the adult rat result in only marginal damage to local neurons. Perforant path transections, removing glutamatergic afferents to hippocampal granule cells, make the latter markedly more vulnerable to a subsequent MSG inj...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Köhler C,Schwarcz R

    更新日期:1981-05-04 00:00:00

  • Heat shock protein 72 restores cyclic AMP accumulation after heat shock in N18TG2 cells.

    abstract::Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki S

    更新日期:1998-04-20 00:00:00

  • Progesterone regulation of catecholamine secretion from chromaffin cells.

    abstract::Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Armstrong SM,Stuenkel EL

    更新日期:2005-05-10 00:00:00

  • Serotonin agonists mimic the phase shifting effects of light on the melatonin rhythm in rats.

    abstract::The effect of serotonin agonists on the rhythmic excretion of the melatonin metabolite 6-sulphatoxymelatonin was examined in rats. The animals were maintained in 12L:12D and administered saline, quipazine (10 mg/kg), (+/-)-2-propylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (8-OH-DPAT, 5 mg/kg) or buspi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kennaway DJ,Rowe SA,Ferguson SA

    更新日期:1996-10-21 00:00:00

  • Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate.

    abstract::Slices of the molecular layer of the dentate gyrus of the hippocampal formation were incubated with either [14C]glucose, [14C]pyruvate or 14C glutamine and the efflux of endogenous and radioactive glutamate was monitored under various conditions. After prelabeling with either [14C]glutamine or [14C]glucose elevation o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hamberger AC,Chiang GH,Nylén ES,Scheff SW,Cotman CW

    更新日期:1979-06-08 00:00:00

  • The effects of antidromic discharges on orthodromic firing of primary afferents in the cat.

    abstract::This study investigated the effects of antidromically conducted nerve impulses on the transmission of orthodromic volleys in primary afferents of the hindlimb in decerebrated paralyzed cats. Two protocols were used: (A) Single skin and muscle afferents (N=20) isolated from the distal part of cut dorsal rootlets (L7-S1...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gossard JP,Bouyer L,Rossignol S

    更新日期:1999-04-17 00:00:00

  • Expression of non-angiotensin II -125I-CGP 42112 binding sites on activated microglia after kainic acid induced neurodegeneration.

    abstract::[125I]CGP 42112, first developed to identify angiotensin II receptor subtype 2 (AT2), was recently shown to bind to a novel non-angiotensin binding site in injured rat brain tissue. We addressed the question whether non-angiotensin [125I]CGP 42112 binding appears after kainic acid induced hippocampal neurodegeneration...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jöhren O,Viswanathan M,Saavedra JM

    更新日期:1995-12-08 00:00:00

  • Nestin small interfering RNA (siRNA) reduces cell growth in cultured astrocytoma cells.

    abstract::Nestin is an embryonic intermediate filament that transiently expressed in the neural stem/progenitor cells in the developing central nervous system (CNS). Growing evidence has shown that abundant expression of nestin also occurs in both pathological glial-derived tumor cells and reactive astrocytes in various CNS inj...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wei LC,Shi M,Cao R,Chen LW,Chan YS

    更新日期:2008-02-27 00:00:00

  • Pregabalin increases food intake through dopaminergic systems in the hypothalamus.

    abstract::Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ikeda H,Yonemochi N,Ardianto C,Yang L,Kamei J

    更新日期:2018-12-15 00:00:00

  • Neurally mediated hyperactive voiding in spontaneously hypertensive rats.

    abstract::The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive voiding in rats with urethral obstruction are characterized by abnormal smooth muscle growth, increased tissue levels of nerve growth factor (NGF) and altered patterns of innervation. The present study was undertaken to determine ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Spitsbergen JM,Clemow DB,McCarty R,Steers WD,Tuttle JB

    更新日期:1998-04-20 00:00:00

  • Contribution of the human superior parietal lobule to spatial selection process: an MEG study.

    abstract::The magnetoencephalographic signal was collected in a visually guided response-finger selection GO/NOGO task. The minimum norm distributed source analysis identified the sources in bilateral superior parietal lobules (SPL), with stronger activity for contralateral finger movement. Our results suggest that the human SP...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shibata T,Ioannides AA

    更新日期:2001-04-06 00:00:00

  • Effects of morphine tolerance and abstinence on cellular immune function.

    abstract::Female B6C3F1 mice were rendered tolerant-dependent on morphine by a combination of injections and pellet implantation. Mice were injected with morphine sulfate (20 mg/kg, s.c.) twice a day on day 1. On day 2, they were implanted s.c. with a 75 mg morphine pellet for 3 days. On day 5, the pellets were either left inta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bhargava HN,Thomas PT,Thorat S,House RV

    更新日期:1994-04-11 00:00:00