当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Two novel types of L-glutamate receptors with affinities for NMDA and L-cysteine in the olfactory organ of the Caribbean spiny lobster Panulirus argus.

Two novel types of L-glutamate receptors with affinities for NMDA and L-cysteine in the olfactory organ of the Caribbean spiny lobster Panulirus argus.

Abstract：

:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable using a non-competitive model that incorporates excitatory and inhibitory transduction pathways, J. Comp. Physiol. A 178 (1992) 523-536). In this study, we have used biochemical and electrophysiological techniques to understand the role of these receptors in olfactory transduction, and to compare these olfactory glutamate receptors with peripheral and central L-glutamate receptors in other animals. Using a radioligand-binding assay with a membrane-rich preparation from the dendrites of olfactory receptor neurons, we have identified two types of binding sites for L-glutamate. Both sites showed rapid, reversible, and saturable association with radiolabeled L-glutamate, and their Kd values (1 nM and 3 microM) are effective in physiological studies of glutamate-sensitive olfactory neurons, suggesting these binding sites are receptors involved in olfactory transduction. Both sites were completely inhibited by high concentrations of NMDA and L-cysteine, and only partially inhibited by other L-glutamate analogs and odorants. Electrophysiological recordings from L-glutamate-best olfactory receptor neurons showed that NMDA and L-cysteine are both partial agonists and antagonists of glutamate receptors. Together, these results suggest the olfactory L-glutamate receptors of spiny lobsters are novel types of L-glutamate receptors that are functionally important in mediating olfactory responses.

journal_name

Brain Res

journal_title

Brain research

authors

Burgess MF,Derby CD

doi

10.1016/s0006-8993(97)00816-0

subject

Has Abstract

pub_date

1997-10-17 00:00:00

pages

292-304

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(97)00816-0

journal_volume

771

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography.

    abstract：:Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) is a potent neuroexcitatory compound which acts at the quisqualate class of excitatory amino acid receptors. In this study we describe the pharmacological characteristics and anatomical distribution of [3H]AMPA binding sites in rat brain using quantitativ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)90636-x

    authors： Monaghan DT,Yao D,Cotman CW

    更新日期：1984-12-17 00:00:00

  • Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum.

    abstract：:Based on electrophysiological data showing that repeated cocaine administration produces persistent enhancement of D1 dopamine (DA) receptor-mediated responses in nucleus accumbens (NAc), we investigated whether changes in neurochemical properties of these receptors resulted when rats were injected with cocaine (15 mg...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90783-6

    authors： Mayfield RD,Larson G,Zahniser NR

    更新日期：1992-02-28 00:00:00

  • Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides.

    abstract：:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90244-6

    authors： Lawrence KM,De Paermentier F,Cheetham SC,Crompton MR,Katona CL,Horton RW

    更新日期：1990-08-27 00:00:00

  • Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats.

    abstract：:Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.01.015

    authors： Neumann A,Hoey RF,Daigler LB,Thompson AC,Kristal MB

    更新日期：2009-03-19 00:00:00

  • Some properties of solubilized GABA receptor.

    abstract：:gamma-Aminobutyric acid (GABA) receptor was solubilized from synaptic membrane of the rat brain by various detergents. Nonidet P-40, a non-ionic detergent, was found to be an effective solubilizing agent, since it caused no interference on the receptor binding assay, yielded a [3H]muscimol binding protein with a high ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(82)90720-x

    authors： Ito Y,Kuriyama K

    更新日期：1982-03-25 00:00:00

  • Opposite effects of acute and chronic amphetamine on Nurr1 and NF-κB p65 in the rat ventral tegmental area.

    abstract：:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2016.09.031

    authors： Arredondo C,González M,Andrés ME,Gysling K

    更新日期：2016-12-01 00:00:00

  • Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo.

    abstract：:Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.04.014

    authors： He LF,Chen HJ,Qian LH,Chen GY,Buzby JS

    更新日期：2010-06-21 00:00:00

  • Distribution of guanine nucleotide-binding protein in the brain of the reeler mutant mouse.

    abstract：:The localization of a GTP-binding protein (G(o)) in the cerebellar and cerebral cortex and hippocampus of the normal and reeler mutant mouse was immunohistochemically examined using affinity-purified antibody raised against the alpha subunit of G(o). Although the general distribution pattern of G(o)-immunoreactive pro...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91704-v

    authors： Terashima T,Katada T,Ichikawa R,Ui M,Inoue Y

    更新日期：1993-01-22 00:00:00

  • Three-dimensional localization of dipoles for potentials evoked by posterior tibial nerve stimulation in the monkey.

    abstract：:Somatosensory evoked potentials (SEPs) elicited by right posterior tibial nerve stimulation were simultaneously recorded from 21-27 epidural electrodes in three monkeys. N23-P40 was recorded anterior to the left central sulcus, and P23-N40 was recorded on the parietal midline and the middle portion of the right hemisp...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)81685-x

    authors： Hayashi N,Nishijo H,Endo S,Ono T

    更新日期：1997-11-07 00:00:00

  • Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.

    abstract：:Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)02445-2

    authors： Pugh CR,Johnson JD,Martin D,Rudy JW,Maier SF,Watkins LR

    更新日期：2000-04-07 00:00:00

  • Hypothalamic control of thermoregulation during dehydration.

    abstract：:Hypothalamic control of thermoregulatory evaporation has been examined in hydrated and dehydrated cats exposed to warm ambient temperatures. Reduction in evaporative cooling during dehydration is associated with increased hypothalamic temperature. Local thermal stimulation of the hypothalamus indicates that the thermo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(81)90120-7

    authors： Doris PA,Baker MA

    更新日期：1981-02-09 00:00:00

  • Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment.

    abstract：:Peripheral axotomy in neonatal rats induces neuronal death. We studied the anti-apoptotic protein Bcl-2 and cell death promoter Bax in spinal cord of neonatal rats after sciatic transection and treatment with melatonin, a neuroprotective substance. Pups were unilaterally axotomized at P2 and received melatonin (1 mg/k...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.07.021

    authors： Rogério F,Jordão H Jr,Vieira AS,Maria CC,Santos de Rezende AC,Pereira GA,Langone F

    更新日期：2006-09-27 00:00:00

  • LY393615, a novel neuronal Ca(2+) and Na(+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia.

    abstract：:In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)03043-2

    authors： O'Neill MJ,Hicks CA,Ward MA,Osborne DJ,Wishart G,Mathews KS,McLaughlin DP,Stamford JA,McCarty DR,Patrick KE,Roman C,Fleisch JH,Gilmore J,Boot JR

    更新日期：2001-01-05 00:00:00

  • Early and permanent effects of monocular deprivation on pattern discrimination and visuomotor behavior in cats.

    abstract：:Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90771-x

    authors： Hof-Van Duin JV

    更新日期：1976-07-30 00:00:00

  • Brain blood flow and extracerebral carotid circulation during sleep in rat.

    abstract：:Cerebral blood flow (CBF) and blood flow (BF) in extracerebral head structures were measured during the sleep-wake cycle in rats using radioactive microspheres. While no statistically significant changes occurred in the transition from Waking to quiet sleep (also referred to as synchronized or non-REM Sleep), CBF incr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91813-9

    authors： Zoccoli G,Bach V,Cianci T,Lenzi P,Franzini C

    更新日期：1994-03-28 00:00:00

  • Effects of para-chloroamphetamine upon the serotonergic innervation of the rat hippocampus.

    abstract：:The ability of hippocampal serotonergic (5-HT) axons to proliferate in response to damage by para-chloroamphetamine (PCA) was examined in this study. Synaptosomal uptake of 5-HT in the hippocampal formation was decreased to 40% of control 3 days after systemic administration of PCA. Six weeks after PCA, uptake values ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90281-d

    authors： Haring JH,Meyerson L,Hoffman TL

    更新日期：1992-04-17 00:00:00

  • Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice.

    abstract：:A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2014.01.006

    authors： Sasaki S,Takenari Yamashita,Hideyama T,Kwak S

    更新日期：2014-03-06 00:00:00

  • Modulatory effects of progesterone upon dopamine release from the corpus striatum of ovariectomized estrogen-treated rats are stereo-specific.

    abstract：:We have shown previously that progesterone linked with bovine serum albumin at position 3 of the progesterone molecule (P-3-BSA) was effective in modulating (both stimulating and inhibiting) amphetamine (AMPH)-evoked dopamine (DA) release in vitro from superfused corpus striatal (CS) tissue fragments of ovariectomized...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)90395-c

    authors： Dluzen DE,Ramirez VD

    更新日期：1991-01-04 00:00:00

  • The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.

    abstract：:The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91604-q

    authors： Janusz CA,Berman RF

    更新日期：1993-08-13 00:00:00

  • Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.

    abstract：:Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to modulate a wide range of processes including attention, arousal, autonomic control and sensory processing. A spinal projection from the locus coeruleus (LC) is thought to regulate nociceptive processing. To characterize and selectivel...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2016.02.023

    authors： Li Y,Hickey L,Perrins R,Werlen E,Patel AA,Hirschberg S,Jones MW,Salinas S,Kremer EJ,Pickering AE

    更新日期：2016-06-15 00:00:00

  • Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors.

    abstract：:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In al...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)91326-x

    authors： Zukin SR,Brady KT,Slifer BL,Balster RL

    更新日期：1984-02-27 00:00:00

  • Genetic causes of amyotrophic lateral sclerosis: new genetic analysis methodologies entailing new opportunities and challenges.

    abstract：:The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly understood. In this far-reaching review, we examine what is currently known about ALS genetics and how these genes were initially identified. We also discuss the various types of mutations that might underlie this fatal neurodegenera...

    journal_title：Brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.brainres.2014.10.009

    authors： Marangi G,Traynor BJ

    更新日期：2015-05-14 00:00:00

  • QRFP administration into the medial hypothalamic nuclei improves memory in rats.

    abstract：:Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is known regarding cognitive effects of recently discovered neuropeptide QRFP. Considering multiple physiological functions of QRFP, localization of QRFP-synthesizing neurons in the hypo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.146563

    authors： Zagorácz O,Ollmann T,Péczely L,László K,Kovács A,Berta B,Kállai V,Kertes E,Lénárd L

    更新日期：2020-01-15 00:00:00

  • Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.

    abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(03)02526-5

    authors： Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

    更新日期：2003-05-30 00:00:00

  • Discrimination between changes in glucocorticoid receptor expression and activation in rat brain using western blot analysis.

    abstract：:These studies investigated autoregulation of glucocorticoid receptor (GR) protein expression and activation in rat brain using western blot methodology. By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR act...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02341-6

    authors： Spencer RL,Kalman BA,Cotter CS,Deak T

    更新日期：2000-06-23 00:00:00

  • Adaptation of female rats to stress: shift to male pattern by inhibition of corticosterone synthesis.

    abstract：:In a previous study, male rats showed behavioural deficits after a single restraint stress but not after 5 daily restraint periods (i.e. adaptation had developed): female rats although less affected by single restraint failed to adapt over the same time course. This sex difference was associated with the male but not ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)90476-3

    authors： Haleem DJ,Kennett G,Curzon G

    更新日期：1988-08-23 00:00:00

  • An indirect projection from the nucleus of the solitary tract to the central nucleus of the amygdala via the parabrachial nucleus in the rat: a light and electron microscopic study.

    abstract：:The morphological basis of how visceral information from the nucleus of the solitary tract (NTS) is relayed from the parabrachial nucleus (PBN) to the central nucleus of the amygdala (Ce) was studied at the light and electron microscopic levels using the anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91262-9

    authors： Jia HG,Rao ZR,Shi JW

    更新日期：1994-11-14 00:00:00

  • Lesions of the accessory olfactory bulb decrease lordotic responsiveness and reduce mating-induced c-fos expression in the accessory olfactory system.

    abstract：:The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)90902-4

    authors： Dudley CA,Moss RL

    更新日期：1994-04-11 00:00:00

  • Delayed kindling epileptogenesis and increased neurogenesis in adult rats housed in an enriched environment.

    abstract：:Environmental risk factors such as stressful experiences have long been recognized to affect seizure susceptibility, but little attention has been paid to the potential effects of improving housing conditions. In this study, we investigated the influence of an enriched environment on epileptogenesis. Epileptic suscept...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)03355-3

    authors： Auvergne R,Leré C,El Bahh B,Arthaud S,Lespinet V,Rougier A,Le Gal La Salle G

    更新日期：2002-11-08 00:00:00

  • Serotonin increases the frequency of light-elicited discrete waves in type-B photoreceptors of Hermissenda.

    abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)90969-t

    authors： Crow T,Pengidore T

    更新日期：1993-11-19 00:00:00