Abstract：
:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.
journal_name
Brain Resjournal_title
Brain researchauthors
Zukin SR,Brady KT,Slifer BL,Balster RLdoi
10.1016/0006-8993(84)91326-xsubject
Has Abstractpub_date
1984-02-27 00:00:00pages
174-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)91326-Xjournal_volume
294pub_type
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