Alterations in delta opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study.

Abstract:

:The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be remarkably stable throughout the life span of this species. We have, however, discovered anatomical areas which offer striking exceptions. In the globus pallidus, progressive age-related losses of delta receptors reached 50% in the senescent animal. In contrast, laminae I, II of the lateral agranular frontal cortex and laminae I, II and III, IV of the primary somatosensory cortex demonstrated age-related increases in the concentrations of delta receptors ranging from 30 to 45%. These changes are discussed with the view to their being functionally related components of motor circuitry involving pyramidal and extrapyramidal elements.

journal_name

Brain Res

journal_title

Brain research

authors

Hiller JM,Fan LQ,Simon EJ

doi

10.1016/0006-8993(93)91021-j

subject

Has Abstract

pub_date

1993-06-18 00:00:00

pages

86-98

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91021-J

journal_volume

614

pub_type

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