Evidence for the contribution by the cerebral cortex to 5-hydroxyindoleacetic acid found in the cerebrospinal fluid of cats.

Abstract:

:Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIAA and of probenecid suggested that there was a contribution and also a transport mechanism similar to that in the choroid plexus.

journal_name

Brain Res

journal_title

Brain research

authors

Min-Chu L,Mackenna BR,Watt JA

doi

10.1016/0006-8993(81)91187-2

subject

Has Abstract

pub_date

1981-03-23 00:00:00

pages

235-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)91187-2

journal_volume

209

pub_type

杂志文章
  • Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia.

    abstract::Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present stud...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.02.140

    authors: Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen L

    更新日期:2006-07-07 00:00:00

  • TGF-beta1 increases tyrosine hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells.

    abstract::Human neuroblastoma SH-SY5Y cells were used to study the effects of transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2) on neuronal differentiation and acquisition of a catecholaminergic phenotype. SH-SY5Y cells express the intracellular factors activated through the receptors of the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03680-6

    authors: Gómez-Santos C,Ambrosio S,Ventura F,Ferrer I,Reiriz J

    更新日期:2002-12-20 00:00:00

  • Dopaminergic substrates of amphetamine-induced place preference conditioning.

    abstract::The conditioned place preference paradigm was used to study the reinforcing properties of D-amphetamine. Rats were injected (i.p.) with D-amphetamine sulphate (0.5, 1.0 or 5.0 mg/kg) and 10 min later confined for 30 min to one side of a shuttle box in which each of the two compartments had distinctive features. On alt...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90685-0

    authors: Spyraki C,Fibiger HC,Phillips AG

    更新日期:1982-12-16 00:00:00

  • Activity of muscle spindles, motor cortex and cerebellar nuclei during action tremor.

    abstract::Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90308-1

    authors: Elble RJ,Schieber MH,Thach WT Jr

    更新日期:1984-12-10 00:00:00

  • Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides.

    abstract::Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90244-6

    authors: Lawrence KM,De Paermentier F,Cheetham SC,Crompton MR,Katona CL,Horton RW

    更新日期:1990-08-27 00:00:00

  • Interaction between descending paraventricular neurons and vagal motor neurons.

    abstract::The hypothalamic paraventricular nucleus is known to send projections to the dorsal medullary area where it appears to innervate the nucleus tractus solitarius and the dorsal motor nucleus of the vagus. Experiments were carried out in urethane anesthetized rats to identify single vagal motor neurons identified by anti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90399-3

    authors: Lawrence D,Pittman QJ

    更新日期:1985-04-15 00:00:00

  • Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

    abstract::Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01488-8

    authors: McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

    更新日期:1996-03-25 00:00:00

  • A new densitometric procedure to measure protein levels in tissue slices used in quantitative autoradiography.

    abstract::A new quantitative staining technique for the assay of protein in tissue sections using the dye Coomassie brilliant blue G 250 is discussed. This densitometric procedure uses commercially available hardware and software employed in the quantitation of receptor autoradiographs. Rather than assuming a homogeneous distri...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90965-1

    authors: Miller JA,Curella P,Zahniser NR

    更新日期:1988-04-26 00:00:00

  • Exogenous orienting of visual-spatial attention in ADHD children.

    abstract::Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.11.036

    authors: Ortega R,López V,Carrasco X,Anllo-Vento L,Aboitiz F

    更新日期:2013-02-01 00:00:00

  • Climbing fiber action on the responsiveness of Purkinje cells to parallel fiber inputs.

    abstract::Recent work in our laboratory has demonstrated that spontaneous or evoked climbing fiber inputs are associated with an increased responsiveness of Purkinje cells to mossy fiber inputs activated by natural peripheral stimuli. These experiments were designed to test the hypothesis that this increased responsiveness occu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91027-8

    authors: Ebner TJ,Bloedel JR

    更新日期:1984-08-20 00:00:00

  • The re-establishment of synaptic transmission by regenerating optic axons in goldfish: time course and effects of blocking activity by intraocular injection of tetrodotoxin.

    abstract::Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90958-7

    authors: Schmidt JT,Edwards DL,Stuermer C

    更新日期:1983-06-13 00:00:00

  • Post-ischemic hypothermia reduced IL-18 expression and suppressed microglial activation in the immature brain.

    abstract::Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left ca...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.121

    authors: Fukui O,Kinugasa Y,Fukuda A,Fukuda H,Tskitishvili E,Hayashi S,Song M,Kanagawa T,Hosono T,Shimoya K,Murata Y

    更新日期:2006-11-22 00:00:00

  • The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures.

    abstract::To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01121-3

    authors: Appelt DM,Balin BJ

    更新日期:1997-01-16 00:00:00

  • A rat model of focal embolic cerebral ischemia.

    abstract::We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00580-5

    authors: Zhang RL,Chopp M,Zhang ZG,Jiang Q,Ewing JR

    更新日期:1997-08-22 00:00:00

  • Suppression of acute seizures by theta burst electrical stimulation of the hippocampal commissure using a closed-loop system.

    abstract::This study investigated the effects of electrical stimulation with theta burst stimulation (eTBS) on seizure suppression. Optimal parameters of eTBS were determined through open-loop stimulation experiments and then implemented in a close-loop seizure control system. For the experiments, 4-aminopyridine (4-AP) was inj...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.10.025

    authors: Siah BH,Chiang CC,Ju MS,Lin CC

    更新日期:2014-12-17 00:00:00

  • Macrophage activation and its role in repair and pathology after spinal cord injury.

    abstract::The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation, and specifically macrophage activation, likely plays a key role. Macrophages have the ability to promote the...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2014.12.045

    authors: Gensel JC,Zhang B

    更新日期:2015-09-04 00:00:00

  • Excitatory effects of muscarine on septohippocampal neurons: involvement of M3 receptors.

    abstract::Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the me...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00729-x

    authors: Liu W,Kumar A,Alreja M

    更新日期:1998-09-14 00:00:00

  • Evidence for biological effects of exogenous LPA on rat primary afferent and spinal cord neurons.

    abstract::There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.07.005

    authors: Elmes SJ,Millns PJ,Smart D,Kendall DA,Chapman V

    更新日期:2004-10-01 00:00:00

  • The influence of aging and hypertension on cerebral autoregulation.

    abstract::Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90454-6

    authors: Hoffman WE,Albrecht RF,Miletich DJ

    更新日期:1981-06-09 00:00:00

  • Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.

    abstract::We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90370-o

    authors: Akiyama K,Daigen A,Yamada N,Itoh T,Kohira I,Ujike H,Otsuki S

    更新日期:1992-01-08 00:00:00

  • Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment.

    abstract::Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sens...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01094-7

    authors: Szallasi A,Nilsson S,Farkas-Szallasi T,Blumberg PM,Hökfelt T,Lundberg JM

    更新日期:1995-12-12 00:00:00

  • MDMA (ecstasy) modulates locomotor and prefrontal cortex sensory evoked activity.

    abstract::Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.09.048

    authors: Atkins K,Burks T,Swann AC,Dafny N

    更新日期:2009-12-11 00:00:00

  • Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.

    abstract::Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.050

    authors: Pawlyk AC,Cosmi S,Alfinito PD,Maswood N,Deecher DC

    更新日期:2006-12-06 00:00:00

  • Reduced glucose-induced neuronal activation in the hypothalamus of diet-induced obese rats.

    abstract::Rats predisposed to develop diet-induced obesity (DIO) preferentially activate their sympathetic nervous system during intracarotid glucose infusion [B.E. Levin, Intracarotid glucose-induced norepinephrine response and the development of diet-induced obesity, Int. J. Obesity 16 (1992) 451-457.] but their brains are ge...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00839-7

    authors: Levin BE,Govek EK,Dunn-Meynell AA

    更新日期:1998-10-19 00:00:00

  • Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.

    abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03259-0

    authors: Guo ZL,Lai HC,Longhurst JC

    更新日期:2002-01-18 00:00:00

  • Synaptology of the cerebello-olivary pathway. Double labelling with anterograde axonal tracing and GABA immunocytochemistry in the rat.

    abstract::The dentato-olivary projection has been ultrastructurally studied in rats that received a wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) injection in the nucleus lateralis. Ultrathin sections containing the inferior olive have been double-labelled with the GABA-immunogold method. About 97% of the WGA-HRP labell...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91641-7

    authors: Angaut P,Sotelo C

    更新日期:1989-02-13 00:00:00

  • Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro.

    abstract::In previous studies we found that in the extremely polydipsic special strain of mice, STR/N, spontaneous drinking was greatly attenuated by injection of the opioid antagonists given intracerebroventricularly as well as subcutaneously. Therefore, we investigated, using hypothalamic slice preparations, responses of neur...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90441-w

    authors: Hattori Y,Katafuchi T,Koizumi K

    更新日期:1991-01-11 00:00:00

  • Striatal glutamate release is important for development of ischemic damage to striatal neurons during rat heatstroke.

    abstract::This study attempted to ascertain whether heatstroke-induced ischemia is associated with augmented striatal glutamate release and can be attenuated by NMDA receptor antagonists. Mean arterial pressure (MAP), striatal cerebral blood flow (CBF), striatal glutamate release and striatal neuronal damage score were assessed...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00282-0

    authors: Yang YL,Pan WH,Chiu TH,Lin MT

    更新日期:1998-06-08 00:00:00

  • Effect of cocaine on the 5-HT3 receptor-mediated ion current in Xenopus oocytes.

    abstract::The cloned 5-HT3 receptor from NCB-20 neuroblastoma cells was expressed in Xenopus oocytes. In these oocytes, 5-HT, the selective 5-HT3 receptor agonists, 2-methyl-5-HT and m-chlorophenylbiguanide activated an inward current which was sensitive to the specific 5-HT3 receptor antagonist LY278584. Cocaine (0.1 to 10 mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)01316-a

    authors: Fan P,Oz M,Zhang L,Weight FF

    更新日期:1995-03-06 00:00:00

  • Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat.

    abstract::The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90373-u

    authors: Fellows LK,Boutelle MG

    更新日期:1993-02-26 00:00:00