Abstract：
:Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present study, the administration of G-CSF significantly increased number of CD34(+) cells in the marginal zone of the infarction. Rats receiving G-CSF had higher survival rate and lower infarction volume. Neurological behavior was improved, and the expression of fibronectin in the ischemic brain was increased, as compared to rats treated with vehicle. To mimic the ischemia-reperfusion injury in experimental animals, we employed hippocampal slice cultures that were first treated with oxygen and glucose deprivation (OGD) and then with oxygen-glucose resupply, finding that fibronectin significantly increased the neurite outgrowth of OGD hippocampal slices, upregulated the expression of Bcl-2 protein, and ameliorated the ultrastructure damage of OGD hippocampal slices.
journal_name
Brain Resjournal_title
Brain researchauthors
Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen Ldoi
10.1016/j.brainres.2006.02.140subject
Has Abstractpub_date
2006-07-07 00:00:00pages
161-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)00522-1journal_volume
1098pub_type
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