Effect of varying levels of glucose on oxygen deprivation-induced delayed neuronal cell death in primary cerebrocortical cultures.

Abstract:

:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed to combined oxygen deprivation and low glucose (1.7 or 0.6 mM). Although those cultures deprived of oxygen combined with no glucose displayed delayed increases in 45Ca2+ influx, no significant elevation in LDH release at 24 h was observed.

journal_name

Brain Res

journal_title

Brain research

authors

Birrell GJ,Marcoux FW

doi

10.1016/0006-8993(93)91527-y

subject

Has Abstract

pub_date

1993-04-02 00:00:00

pages

337-40

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91527-Y

journal_volume

607

pub_type

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