Abstract:
:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed to combined oxygen deprivation and low glucose (1.7 or 0.6 mM). Although those cultures deprived of oxygen combined with no glucose displayed delayed increases in 45Ca2+ influx, no significant elevation in LDH release at 24 h was observed.
journal_name
Brain Resjournal_title
Brain researchauthors
Birrell GJ,Marcoux FWdoi
10.1016/0006-8993(93)91527-ysubject
Has Abstractpub_date
1993-04-02 00:00:00pages
337-40issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91527-Yjournal_volume
607pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Opioid antagonists block the positive hedonic response to food taste and are potent inhibitors of palatability-driven feeding. However, the specific brain regions within which opioid peptide secretion contributes to the maintenance of palatability-driven feeding have not been clearly established. In the present study,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00719-7
更新日期:1998-09-14 00:00:00
abstract::Electrophysiological techniques and the retrograde transport of horseradish peroxidase (HRP) were used to determine the efferent projections from the caudal mediobasal hypothalamus to the amygdala. In pentobarbital anesthetized rats, the activity of 1780 mediobasal hypothalamic neurons was examined for response to sti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90147-0
更新日期:1977-02-01 00:00:00
abstract::Using gold-labelled somatostatin, somatostatin binding sites were predominantly found in laminae I-III, X and on motorneurones of the rat lumbar spinal cord. A comparison with immunohistochemical staining using antisera against somatostatin receptor sequences revealed that the marked binding in laminae I-III coincided...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01226-8
更新日期:1999-01-16 00:00:00
abstract::Although norepinephrine-containing nerve terminals in the spinal cord synapse in the vicinity of sympathetic preganglionic cells, their effect on sympathetic outflow has remained unclear. Since survival during hypotension necessitates sustaining maximal sympathetic activity, we used experimental hypotension as a physi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90978-9
更新日期:1986-06-04 00:00:00
abstract::cGMP was proposed to be the agent which directly opens the light-sensitive channel in Limulus ventral photoreceptors. However, the light-sensitive rhabdomeral-lobe (R-lobe) is not uniformly responsive to cGMP injection; that is, there are 'hot spots' of sensitivity. A potent phosphodiesterase which rapidly hydrolyses ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90094-c
更新日期:1991-06-28 00:00:00
abstract::The active and passive properties of petrosal ganglion sensory neurons with axons in the glossopharyngeal nerve were examined with intracellular microelectrodes in an in vitro preparation. Glossopharyngeal neurons could be classified into two groups: H-cells showing an inflexion or hump on the falling phase of the spi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91418-1
更新日期:1987-01-20 00:00:00
abstract::Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90659-5
更新日期:1983-05-05 00:00:00
abstract::The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91237-8
更新日期:1994-02-21 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.004
更新日期:2008-04-24 00:00:00
abstract::D-Fen-induced hyperthermia has been shown to coincide with an enhanced depletion of 5-HT and 5-hydroxyindole acetic acid (5-HIAA). Because these observations have relied on D-Fen exposure at multiple environmental temperatures, some have questioned the validity of the findings. Therefore, this experiment was designed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01732-1
更新日期:1999-08-28 00:00:00
abstract::Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01064-1
更新日期:1999-03-06 00:00:00
abstract::Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.066
更新日期:2008-03-04 00:00:00
abstract::Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.10.066
更新日期:2013-01-23 00:00:00
abstract::Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91127-7
更新日期:1983-03-28 00:00:00
abstract::Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.030
更新日期:2008-03-14 00:00:00
abstract::Rat hippocampal minces were loaded with [acetyl 1-14C]acetylcholine ([14C]ACh) in the presence of the "poorly penetrating" acetylcholinesterase (EC 3.1.1.7; AChE) inhibitor echothiophate and the effect of high K+ depolarization determined on the subcellular storage and release of [14C]ACh and its metabolites. Results ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00078-9
更新日期:1996-06-24 00:00:00
abstract::The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic group of motoneurons in Rexed's Lamina X of the lumbosacral spinal cord of the Mongolian gerbil. The SNB innervates the perineal musculature, the bulbocavernosus (BC), levator ani (LA), and external anal sphincter (EAS). Recent studies demonstrate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02949-9
更新日期:2002-10-25 00:00:00
abstract::In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90286-9
更新日期:1976-08-13 00:00:00
abstract::The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90953-2
更新日期:1982-10-28 00:00:00
abstract::The postnatal development of cat triceps surae gamma-motoneurones, retrogradely labelled with horseradish peroxidase (HRP), was studied light and electron microscopically. The mean diameter of the cell bodies of the gamma-motoneurones increased by about 25% from birth to the adult stage, which was much less than the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90251-3
更新日期:1987-12-15 00:00:00
abstract::Synaptic glomeruli in the nucleus submedius of the rat are described and the source of some of the component terminals identified. The glomeruli consist of large terminals with round synaptic vesicles establishing Gray type I contacts with dendrites and surrounded by layers of astrocyte derived membranes. The astrocyt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90215-0
更新日期:1987-07-14 00:00:00
abstract::Rats anticipate a scheduled daily meal by entrainment of a circadian pacemaker separate from the light-entrainable circadian pacemaker located in the suprachiasmatic nuclei (SCN). The site and molecular mechanisms of the food-entrainable pacemaker are unknown. The intrinsic period (tau) of the SCN pacemaker is signifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03042-6
更新日期:2001-11-23 00:00:00
abstract::This study investigated the role of strain and vendor differences on the outcome of focal cerebral ischemia in the rat induced by occlusion of the middle cerebral artery by an intraluminal thread. The cortical infarct volumes (Mean +/- S.E.M.) were: 14.2 +/- 6.2 mm3 in Simonsen Laboratories Sprague-Dawley rats; 84.0 +...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00033-m
更新日期:1995-03-27 00:00:00
abstract::Interest in the role of membrane lipids in Schwann cell function prompted this study of lipid antigens on myelin- and non-myelin forming Schwann cells. Using the monoclonal antibodies 07, which recognises galactocerebroside, 08, 09 and 011, the distribution and time course of expression of the 4 membrane lipids have b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90049-6
更新日期:1987-10-01 00:00:00
abstract::Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00940-r
更新日期:1995-11-27 00:00:00
abstract::Inbred mouse strains differed significantly in sensitivity to convulsions induced by 9 convulsant drugs administered using a timed infusion procedure. Some strains (e.g. BALB/cJ, A/J) were generally seizure-susceptible, while some were generally seizure resistant (e.g. C57BL/6J, SWR/J). However, the overall pattern of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90243-5
更新日期:1990-08-27 00:00:00
abstract::Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.01.020
更新日期:2015-03-30 00:00:00
abstract::Electrical stimulation of the brain, particularly in the periventricular grey areas, caused long-lasting increases in behavioural escape thresholds to heating and mechanical stimuli applied to the facial region of the rat. The brain stimulation selectively suppressed responses to noxious stimuli. Responses to non-noxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00927-i
更新日期:1995-11-27 00:00:00
abstract::Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91583-z
更新日期:1992-08-21 00:00:00
abstract::Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical cir...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02170-3
更新日期:2000-07-07 00:00:00