Abstract:
:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased immunostaining for the high molecular weight microtubule-associated protein-2a/b. This increase was observed 2 weeks after training and it was selective for hippocampal CA1 and CA2 pyramidal cells. Pre-exposure to the training context one month before training altered the hippocampal microtubule-associated protein-2 response; in these animals only the dentate gyrus showed significantly increased microtubule-associated protein-2a/b. Training-related increases in immunohistochemical staining for microtubule-associated protein-2 suggested that there was an increase in overall intact protein, an increase in immunoreactive breakdown products, or changes in protein compartmentalization. Immunoblots of hippocampal homogenates reacted with monoclonal antibodies to microtubule-associated protein-2a/b showed an increased presence of breakdown products in trained animals compared to untrained controls. Additional immunoblot studies demonstrated statistically significant decreases in the levels and/or phosphorylation state of the low molecular weight microtubule-associated protein-2c in the hippocampus of trained animals as compared to that of controls. These alterations in microtubule-associated protein-2 may reflect dendritic remodeling related to contextual memory storage.
journal_name
Brain Resjournal_title
Brain researchauthors
Woolf NJ,Zinnerman MD,Johnson GVdoi
10.1016/s0006-8993(99)01064-1subject
Has Abstractpub_date
1999-03-06 00:00:00pages
241-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01064-1journal_volume
821pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Auditory transients (such as sound onset or a frequency transition within a continuous sound) are assumed to parse the auditory input into smaller units enabling the formation of unitary sound representations separately for each segment. This was discovered by using the mismatch negativity (MMN) component of the event...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.046
更新日期:2012-06-29 00:00:00
abstract::The effects of selective dopamine D1 (SKF 38393) and D2 (4-propyl-9-hydroxynaphthoxazine or PHNO) agonists on free-running rhythms of locomotor activity in rats were investigated under either constant light (LL) or dark (DD) condition. Rats under the DD condition exhibited clear circadian patterns of activity, while c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90445-2
更新日期:1991-01-11 00:00:00
abstract::It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2013.01.008
更新日期:2013-05-20 00:00:00
abstract::The firing rate of the neurons of the hypothalamic paraventricular nucleus, the temperatures of the interscapular brown adipose tissue and of the colon (TIBAT and Tc) were monitored in 24 urethane-anesthetized male Sprague-Dawley rats divided into four groups. These variables were measured before and after hippocampal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01227-5
更新日期:1999-04-03 00:00:00
abstract::The effect of increasing amounts of amyloid beta-protein (Abeta) on the number of neurons in the striatum was investigated in APPswe/PS1DeltaE9 transgenic mice. This mouse model of Alzheimer's disease-like amyloidosis displays an increased expression of Abeta in the brain with age. On the basis of reports of disruptio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.025
更新日期:2009-04-17 00:00:00
abstract::Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.090
更新日期:2006-03-29 00:00:00
abstract::The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00423-n
更新日期:1995-07-17 00:00:00
abstract::Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropatho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00929-3
更新日期:1998-01-01 00:00:00
abstract::Sustained seizure activity can be induced in rabbit olfactory bulb by application of brief low-level current via chronically implanted micro-electrodes. Sensitivity to such stimulation is markedly augmented by prior surgical isolation of the ipsilateral or contralateral bulb. The isolated rabbit olfactory bulb appar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90056-6
更新日期:1975-08-29 00:00:00
abstract::Our previous work has revealed increased nitric oxide (NO) production in the cochlear perilymph following noise stress. However, it is not clear if the increase of NO is related to iNOS and whether NO-related oxidative stress can cause vascular tissue damage. In this study, iNOS immunoreactivity, NO production, and re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04090-8
更新日期:2003-03-28 00:00:00
abstract::The lamination of the hippocampus in the homozygous B6CBA weaver mouse (wv/wv) was compared with that in normal B6CBA littermates (+/+) and C57BL/6J mice using Nissl and Timm's staining. In Nissl-stained preparations, the normal littermates exhibit a compact, regular arrangement of pyramidal cells in area CA3 of the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00974-u
更新日期:1995-10-23 00:00:00
abstract::The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90793-x
更新日期:1978-04-21 00:00:00
abstract::Effects of pre-treatment of synaptic membranes with beta-adrenoceptor agonists and cholera toxin on [3H]clonidine and [3H]yohimbine binding were examined in rat cerebral cortex. Pre-incubation of cerebral cortical membranes with isoproterenol (10 or 200 microM) or dobutamine (1, 10 or 200 microM) at 37 degrees C for 4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90531-1
更新日期:1985-03-11 00:00:00
abstract::A simple pressure injection technique was developed to deliver substances into specific regions of the embryonic and neonatal mouse brain in vivo. The retrograde tracers Fluorogold and cholera toxin B subunit were used to test the validity of the technique. Injected animals survived the duration of transport (24-48 h)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.024
更新日期:2010-01-11 00:00:00
abstract::We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90937-5
更新日期:1984-08-06 00:00:00
abstract::We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a con...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.061
更新日期:2009-01-12 00:00:00
abstract::Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Foll...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-07-08 00:00:00
abstract::In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90094-0
更新日期:1987-01-01 00:00:00
abstract::Neuropeptide Y (NPY) blocks the effect of light on the mammalian circadian clock during the subjective night. The present study explores the role of the NPY Y1 receptor in this interaction. The effect of NPY when co-applied with NMDA, a glutamate agonist that can mimic the effect of light, was examined in NPY Y1-/- mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.037
更新日期:2004-10-08 00:00:00
abstract::Neurons in the ventromedial tegmental area that project to the rostral part of the dorsal cap of the ipsilateral inferior olive were labeled by the technique of retrograde transport of horseradish peroxidase (HRP). Following iontophoresis of HRP into the rostral part of the dorsal cap a cluster of labeled cells are fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90574-2
更新日期:1979-08-31 00:00:00
abstract::The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.024
更新日期:2004-02-20 00:00:00
abstract::To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00971-8
更新日期:1998-11-23 00:00:00
abstract::By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90981-z
更新日期:1991-05-03 00:00:00
abstract::N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.070
更新日期:2009-09-01 00:00:00
abstract::The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.019
更新日期:2003-12-19 00:00:00
abstract::In this study, seizures in the dentate gyrus were triggered by 2 Hz electrical stimulation while, at the same time, serial changes in paired-pulse depression was measured in free-moving rats. The perforant path was stimulated by paired pulses 25 ms apart and recordings were made in the dentate gyrus. We also observed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01118-9
更新日期:1997-11-21 00:00:00
abstract::The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01933-2
更新日期:1999-10-02 00:00:00
abstract::Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity. SHBG has receptors on plasma membranes of the prostate gland where binding of the 5alpha-reduced androgen di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02956-6
更新日期:2002-09-06 00:00:00
abstract::Ischemic-reperfusion injury in humans occurs in conditions such as stroke, cardiac arrest, subarachnoid hemorrhage or head trauma. Maximal tissue damage is observed during reperfusion, which is primarily attributed to oxidative injury resulting from production of oxygen free radicals. One of the major consequences of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00009-1
更新日期:1996-04-22 00:00:00
abstract::(1) Spontaneous barbiturate spindles were recorded from the primary and secondary somatosensory cortex. The recordings were concentrated to areas surrounding several reference loci. The recording sites producing the maximal response evoked by stimulation of an exposed nerve in a contralateral limb were used as referen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90984-7
更新日期:1976-01-09 00:00:00