Abstract：
:Auditory transients (such as sound onset or a frequency transition within a continuous sound) are assumed to parse the auditory input into smaller units enabling the formation of unitary sound representations separately for each segment. This was discovered by using the mismatch negativity (MMN) component of the event-related potential (ERP) that taps into auditory sensory memory representations. For unstructured sounds, MMN amplitude decreased or even vanished with increasing the temporal distance of an irregular feature (deviance, e.g. duration decrement) relative to the onset of an otherwise regularly occurring sound, whereas for sounds that were segmented by a transient, MMN persisted. It has been speculated that the P1-N1-P2 complex, indexing the sensory encoding of the transient, determines the temporal units of the acoustic input that are represented by the information processing system. To test this hypothesis, we utilized a previously reported asymmetry in the sensory encoding of physically identical but time-reversed transitions between segments of constant and gliding frequency. In separate blocks, we regularly presented 1400-ms sounds with a centered constant-to-glide or glide-to-constant transition. Occasionally and unpredictably, one of the regularly occurring sounds was shortened in duration to 910 ms. We found larger transition-related P1-N1-P2 potentials accompanied by larger deviance-related MMN amplitudes for sounds with constant-to-glide transition than for sounds with glide-to-constant transition. This provides evidence that it is the precise sensory encoding of the transition which is crucial for automatically parsing the auditory input into smaller units, thus enabling the formation of unitary sound representations even for late segments.
journal_name
Brain Resjournal_title
Brain researchauthors
Weise A,Bendixen A,Müller D,Schröger Edoi
10.1016/j.brainres.2012.04.046subject
Has Abstractpub_date
2012-06-29 00:00:00pages
30-42eissn
0006-8993issn
1872-6240pii
S0006-8993(12)00764-0journal_volume
1464pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80031-8
更新日期：1987-04-28 00:00:00
abstract：:Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.005
更新日期：2018-01-01 00:00:00
abstract：:By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS). Further immunoblot analyses showed that the levels of CA II are increased not only in the brain of adult Ts65Dn mice but also in the brain of infants and young ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.023
更新日期：2008-01-23 00:00:00
abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.023
更新日期：2018-08-01 00:00:00
abstract：:Whole-cell patch recordings of neurons in the rostral (gustatory) nucleus tractus solitarius (rNTS) were performed in a brain slice preparation from rat medulla. Neural responses to brief applications (10-45 s) of substance P (SP), via a constant superfusion apparatus, were recorded. SP transiently depolarized 80 of 1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91603-p
更新日期：1993-08-13 00:00:00
abstract：:Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02351-4
更新日期：2001-07-13 00:00:00
abstract：:The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly redu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91033-4
更新日期：1986-01-22 00:00:00
abstract：:FRAT1 was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, which inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. FRAT1 has been identified as a proto-oncogene involved in tumorigenesis. Previous studies have shown that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.037
更新日期：2010-03-12 00:00:00
abstract：:The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were signific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.022
更新日期：2004-12-03 00:00:00
abstract：:The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.076
更新日期：2014-12-10 00:00:00
abstract：:Prenatal cocaine exposure causes alterations in auditory brainstem response in children and experimental animals and has adverse effects on auditory information processing and language skills in children. These effects may result from lesions in the cochlea since this organ is particularly sensitive to chemical insult...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.066
更新日期：2006-05-01 00:00:00
abstract：:The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.006
更新日期：2004-10-29 00:00:00
abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90864-9
更新日期：1985-11-04 00:00:00
abstract：:Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146979
更新日期：2020-11-01 00:00:00
abstract：:PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90184-7
更新日期：1984-11-12 00:00:00
abstract：:Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90772-1
更新日期：1976-07-30 00:00:00
abstract：:We have found that daily subcutaneous injection with a maximum tolerated dose (MTD) of the mGluR2/3 agonist LY379268 (20mg/kg) beginning at 4 weeks dramatically improves the phenotype in R6/2 mice. For example, we observed normalization of motor function in distance traveled, speed, the infrequency of pauses, and the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.026
更新日期：2012-09-14 00:00:00
abstract：:Although norepinephrine-containing nerve terminals in the spinal cord synapse in the vicinity of sympathetic preganglionic cells, their effect on sympathetic outflow has remained unclear. Since survival during hypotension necessitates sustaining maximal sympathetic activity, we used experimental hypotension as a physi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90978-9
更新日期：1986-06-04 00:00:00
abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:A study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson's disease (PD) brain has identified loss of activity only in substantia nigra although loss of activity of this enzyme has been identified in a number of non-brain tissues. We investigated this paradox by studying complex I and other complexes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.061
更新日期：2008-01-16 00:00:00
abstract：:Immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. This innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arisi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90896-1
更新日期：1987-11-24 00:00:00
abstract：:Vascular permeability and intravascular space in the rat cerebral cortex and hypothalamus were assessed 5 and 14 days after the production of either right or left hemisphere frontal cortical suction lesions. Rats were intravenously injected with large (dextran, 50,000 kdalton) and small (inulin, 5000 kdalton) molecula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91414-3
更新日期：1985-12-16 00:00:00
abstract：:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91583-0
更新日期：1994-08-15 00:00:00
abstract：:Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.108
更新日期：2008-06-24 00:00:00
abstract：:Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90782-4
更新日期：1981-09-28 00:00:00
abstract：:Administration of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, stimulates eating behavior in rats. Fos immunohistochemistry was used to determine neural pathways that may play a role in the eating response to MP. The number of cells showing Fos-like immunoreactivity (Fos-li) was quantified by compute...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01143-8
更新日期：1998-01-19 00:00:00
abstract：:This study deals with the synaptology, morphologically identified postsynaptic targets, and origin of somatostatin (SOM) fibers in the rat lateral septal area (LSA) with special reference to those forming pericellular baskets. Septal vibratome sections were immunostained for SOM-14 in 3 experimental groups: control an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91743-k
更新日期：1991-11-22 00:00:00
abstract：:The blood-brain interface in elasmobranchs was examined using physiological and anatomical techniques. Electrolyte analyses of plasma and cerebrospinal fluid (CSF) in control fish and in fish with elevated plasma cation concentration (Ca, Mg or K) demonstrated homeostasis of CSF calcium and magnesium concentrations in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91083-0
更新日期：1981-12-07 00:00:00
abstract：:This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90295-8
更新日期：1988-08-30 00:00:00
abstract：:The distributions and inductions of Cu/Zn superoxide dismutase (SOD), neuronal and endothelial nitric oxide (NO) synthase (nNOS and eNOS), and nitrotyrosine (NT) were immunohistochemically examined in rabbit spinal cords after 5 and 15 min of transient ischemia. The neurons in the anterior horns (AH) were selectively ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00490-8
更新日期：1996-09-02 00:00:00
