Response properties of neurons in the caudate-putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats.

abstract：:The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically signif...

journal_title：Brain research

authors： Braughler JM,Hall ED

更新日期：1981-08-31 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:The ability of membrane-associated peptidases from the brains of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats to metabolize iodinated angiotensin (125I-Ang II) and 125I-Ang III was compared. 125I-Ang II was metabolized to 125I-Ang III and other fragments exclusively by membrane-assoc...

journal_title：Brain research

authors： Cook VI,Wright JW,Wright SA,Harding JW

更新日期：1990-10-08 00:00:00

abstract：:The purpose of this study was to examine whether endothelium-mediated dilation is responsible for the cortical hyperemia that occurs during cortical spreading depression (CSD) in rats using three different approaches. The first approach taken was the acute pharmacological inhibition of the predominant endothelium-cent...

journal_title：Brain research

authors： Shimizu K,Miller AW,Erdös B,Bari F,Busija DW

更新日期：2002-02-22 00:00:00

abstract：:Anisomycin is both a well-established protein synthesis inhibitor and a potent activator of the p38/JNK MAPK pathway. It has been used to block the late phase of long-term potentiation (LTP) and long-term depression (LTD) in hippocampus. In this study, we have found that anisomycin produces a time-dependent decline in...

journal_title：Brain research

authors： Xiong W,Kojic LZ,Zhang L,Prasad SS,Douglas R,Wang Y,Cynader MS

更新日期：2006-04-26 00:00:00

abstract：:We have investigated the role of NMDA receptors in the rat dorsal horn in mediating neuronal responses to noxious hindlimb ischemia, induced by acute occlusion of the femoral artery, as well as in the hyperalgesia evident when noxious mechanical stimuli were applied to the ischemic limb. Two specific NMDA antagonists,...

journal_title：Brain research

authors： Sher GD,Mitchell D

更新日期：1990-07-02 00:00:00

abstract：:Tyrosine hydroxylase (TH) in freshly prepared 45,000 g supernatant from rat striatum was fractionated by DEAE-cellulose chromatography. The elution was made with 2 vols. of buffer (50 mM Tris, pH 7.4; 2 mM dithiothreitol) followed by 4 vols. of a linear NaCl gradient (0 0.3 M) in the same buffer. TH activity was elute...

journal_title：Brain research

authors： Sze PY,Alderson RF,Hedrick BJ

更新日期：1983-05-23 00:00:00

abstract：:The recently identified neuropeptide QRFP(26) is predominantly expressed in the hypothalamus and was suggested to play a role in the regulation of food intake following the observation of an acute orexigenic effect after central administration in mice. QRFP(26) exerts its effect via GPR103 and a newly identified recep...

journal_title：Brain research

authors： Kampe J,Wiedmer P,Pfluger PT,Castaneda TR,Burget L,Mondala H,Kerr J,Liaw C,Oldfield BJ,Tschöp MH,Bagnol D

更新日期：2006-11-13 00:00:00

abstract：:Slow field potentials (SFP) lasting up to 5 s followed penicillin-induced bursts in CA3 of guinea pig hippocampal slices and accounted for most of the interburst interval. The longest lasting component of the SFP which was maximal in the distal apical dendritic region was usually absent in s. pyramidale. Potassium flu...

journal_title：Brain research

authors： Schneiderman JH

更新日期：1987-02-10 00:00:00

abstract：:The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...

journal_title：Brain research

authors： Tapia R,Sitges M

更新日期：1982-11-04 00:00:00

abstract：:Previous work has shown that administration of corticotropin-releasing factor (CRF) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide Y (NPY), and central injection of CRF antagonist, alpha-helical CRF(9-41) enhanced NPY-induced food intake in satiated rats. The aim of the present study was ...

journal_title：Brain research

authors： Menzaghi F,Heinrichs SC,Pich EM,Tilders FJ,Koob GF

更新日期：1993-07-30 00:00:00

abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...

journal_title：Brain research

authors： Arai A,Vanderklish P,Kessler M,Lee K,Lynch G

更新日期：1991-08-02 00:00:00

abstract：:The biochemical and pharmacological properties of an endogenous anticonvulsant substance(s) found in rat cerebrospinal fluid (CSF) following seizures are described. CSF taken from donor rats following a single maximal electroshock (MES) seizure caused significant elevations in seizure thresholds in naive recipient rat...

journal_title：Brain research

authors： Tortella FC,Long JB

更新日期：1988-07-19 00:00:00

abstract：:We investigated the ability of GM1 to induce phosphorylation/activation of the extracellular-regulated protein kinases (ERKs) in the striatum, hippocampus and frontal cortex of aged male Sprague-Dawley rats. Three different treatment paradigms were used: a single application of GM1 to brain slices in situ, a single in...

journal_title：Brain research

authors： Mo L,Ren Q,Duchemin AM,Neff NH,Hadjiconstantinou M

更新日期：2005-08-30 00:00:00

abstract：:Previous studies indicate that 3-acetylpyridine (3-AP) intoxication produces discrete lesions of the inferior olive (IO) and other central structures in rats and mice. As a result, it has been widely employed in investigations of the influences of climbing fibers on cerebellar function. This study examines the central...

journal_title：Brain research

authors： Balaban CD

更新日期：1985-04-01 00:00:00

abstract：:Several studies have recently shown that basal and stress-induced secretion of corticosterone may enhance vulnerability to drugs of abuse. In this report, we studied the effects of metyrapone, an inhibitor of the synthesis of corticosterone, on cocaine-induced locomotion and on the relapse of cocaine self-administrati...

journal_title：Brain research

authors： Piazza PV,Marinelli M,Jodogne C,Deroche V,Rougé-Pont F,Maccari S,Le Moal M,Simon H

更新日期：1994-09-26 00:00:00

abstract：:Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...

journal_title：Brain research

authors： Zagon IS,McLaughlin PJ

更新日期：1991-03-01 00:00:00

abstract：:Calcium-binding proteins play a critical role in vertebrate sensory cells, and some of them have been detected in mechanosensory and chemosensory cells of bony and cartilaginous fishes. In this study immunohistochemistry and Western blot were used to investigate the occurrence and the distribution of S100 protein and ...

journal_title：Brain research

authors： Germanà A,Paruta S,Germanà GP,Ochoa-Erena FJ,Montalbano G,Cobo J,Vega JA

更新日期：2007-08-08 00:00:00

abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...

journal_title：Brain research

authors： Green KM,Linsalata AE,Todd PK

更新日期：2016-09-15 00:00:00

abstract：:The immunohistochemical distributions of tyrosine hydroxylase (TH), calmodulin (CaM) and calcium/CaM-dependent protein kinase II (CaMKII) in the rat forebrain were compared quantitatively to confirm our previous finding that TH activity and dopamine synthesis in the brain are regulated by a calcium/CaM-dependent syste...

journal_title：Brain research

authors： Sutoo D,Akiyama K,Yabe K

更新日期：2002-04-12 00:00:00

abstract：:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...

journal_title：Brain research

authors： Lawrence KM,De Paermentier F,Cheetham SC,Crompton MR,Katona CL,Horton RW

更新日期：1990-08-27 00:00:00

abstract：:Previous studies have shown that long-term 5-hydroxytryptamine (5-HT) depletion induced by combined dorsal and median raphe injections of 5,7-dihydroxytryptamine (5,7-DHT) leads to impairments in the acquisition and performance of behaviour maintained under a differential-reinforcement-of-low-rate (DRL) schedule of re...

journal_title：Brain research

authors： Fletcher PJ

更新日期：1995-03-27 00:00:00

abstract：:We previously found that the dopamine D3 receptor can be split at the third cytoplasmic loop into two fragments (D3trunk and D3tail), and that the mixture of the two fragments retains the binding and functional activity of the wild type receptor. The dopamine D3 receptor gene gives rise to several inactive receptor sp...

journal_title：Brain research

authors： Scarselli M,Novi F,Corsini GU,Maggio R

更新日期：2003-10-17 00:00:00

abstract：:The present study investigated the hypothesis that social isolation increases aggression by increasing the number of V1a vasopressin receptors in the anterior hypothalamus (AH). Male hamsters were randomly assigned to a group that was allowed to interact with a small nonaggressive hamster three times each week for 3 w...

journal_title：Brain research

authors： Albers HE,Dean A,Karom MC,Smith D,Huhman KL

更新日期：2006-02-16 00:00:00

abstract：:Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...

journal_title：Brain research

authors： Smith TP,Sahoo PK,Kar AN,Twiss JL

更新日期：2020-08-01 00:00:00

abstract：:The neuronal threshold, which can be determined by the level of depolarization immediately prior to spike generation, is different for responses to conditioned and discriminated stimuli after conditioning. However, it is impossible to determine excitability within a response to stimuli that failed to generate a spike....

journal_title：Brain research

authors： Tsitolovsky LE,Babkina NV

更新日期：2002-08-09 00:00:00

abstract：:The location of edema and territory of extravasation of serum protein were examined in the white matter of cats with different forms of intracranial pathology following an impact-acceleration injury to the head. Edema was tested with an organic density gradient and Evans blue dye was used as a marker for breakdown of ...

journal_title：Brain research

authors： Tornheim PA,Yi LF,Wagner KL,McLaurin RL

更新日期：1985-06-24 00:00:00

abstract：:Neurophysiological responses were recorded in individual fibers of the lingual and chorda tympani nerves and in single cortical neurons in the rat in response to a battery of tactile, thermal and chemical stimuli applied to the oral cavity. Two categories of thermally sensitive units were identified. Chorda tympani fi...

journal_title：Brain research

authors： Kosar E,Schwartz GJ

更新日期：1990-04-16 00:00:00

abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...

journal_title：Brain research

authors： Muscat L,Tischler RC,Morin LP

更新日期：2005-05-17 00:00:00

abstract：:In albino rats the superior colliculus was stimulated and evoked potentials were explored in the cerebellar hemisphere including the paramedian lobule, and crura I and II. Climbing fiber responses were identified in a strip (ca. 1 mm wide) in the medial region of crus II, extending to both folia a and b. In the tector...

journal_title：Brain research

authors： Akaike T

更新日期：1986-07-16 00:00:00