Abstract：
:We have investigated the role of NMDA receptors in the rat dorsal horn in mediating neuronal responses to noxious hindlimb ischemia, induced by acute occlusion of the femoral artery, as well as in the hyperalgesia evident when noxious mechanical stimuli were applied to the ischemic limb. Two specific NMDA antagonists, D-2-amino-5-phosphonovalerate (APV) and ketamine hydrochloride were applied intrathecally directly on to the spinal cord, in enflurane-anaesthetised rats. Both APV (1 microM and 100 microM) and ketamine (1 mM and 100 mM) inhibited the increase of dorsal horn neuronal firing rate induced by ischemia, but did not alter the neuronal response to noxious pinching or innocuous brushing of the receptive field. Both agents, however, abolished the hyperalgesia to noxious pinching induced by ischemia. Our results support the hypothesis that the excitatory amino acids are involved in the transmission of nociceptive information in the spinal dorsal horn, and also favour a central mechanism for hyperalgesia at the spinal level, possibly also mediated by the NMDA receptor.
journal_name
Brain Resjournal_title
Brain researchauthors
Sher GD,Mitchell Ddoi
10.1016/0006-8993(90)91576-3subject
Has Abstractpub_date
1990-07-02 00:00:00pages
55-62issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91576-3journal_volume
522pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The stress-related neurohormone, corticotropin-releasing factor (CRF), also acts as a neurotransmitter to activate the brain noradrenergic nucleus, locus coeruleus (LC). Previous electrophysiological findings demonstrating that tonic CRF secretion in the LC is increased in adrenalectomized rats suggest that activity o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00900-7
更新日期：1999-01-16 00:00:00
abstract：:Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.036
更新日期：2007-03-16 00:00:00
abstract：:Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00404-6
更新日期：1997-07-18 00:00:00
abstract：:Cocaine (25 mg/kg i.p.) produces analgesia in the rat within 5 min and for a duration of 90 min as determined by the formalin test or for 30 min as determined by the hot plate test. Cocaine analgesia is unaffected by doses of naloxone that are sufficient to attenuate morphine analgesia in both tests. Chlorpromazine (3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91633-8
更新日期：1989-02-13 00:00:00
abstract：:The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90211-7
更新日期：1979-04-27 00:00:00
abstract：:When a pair of stimuli separated by an appropriate interval is given to the right visceropleural connective of Aplysia californica the amplitude of the second EPSP elicited in cell R15 is usually smaller than the amplitude of the first EPSP. In the present paper we show that this phenomenon, synaptic depression, can b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90379-6
更新日期：1976-06-04 00:00:00
abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03358-9
更新日期：2002-11-01 00:00:00
abstract：:Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90163-9
更新日期：1984-04-01 00:00:00
abstract：:Effects of ketamine on glutamate-induced swelling of astrocytes in primary cell culture were studied. Following the exposure to 1 mM glutamate (Glu) for 4 h the intracellular water space (as measured by 3-O-methyl-[14C]glucose uptake) of astrocytes was increased by two-fold concomitant with cell swelling and disappear...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90845-7
更新日期：1989-05-22 00:00:00
abstract：:We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.11.047
更新日期：2012-01-30 00:00:00
abstract：:Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is known regarding cognitive effects of recently discovered neuropeptide QRFP. Considering multiple physiological functions of QRFP, localization of QRFP-synthesizing neurons in the hypo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146563
更新日期：2020-01-15 00:00:00
abstract：:Responses of subthalamic neurons (STN) to the iontophoretic application of glutamate (Glu), acetylcholine (ACh) and GABA were studied in rats 2 or 3 weeks following bilateral decortication, and were compared to those obtained in normal animals. All the cells recorded in lesioned rats showed a decrease in their spontan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90077-1
更新日期：1987-02-17 00:00:00
abstract：:Retinal lesions in pigeons produced a marked depletion of somata and neuropil staining for both calbindin-D28k and parvalbumin immunoreactivities in the contralateral optic tectum. Calbindin-like immunoreactivity reappeared in some tectal layers by 6 weeks postlesion, whereas paravalbumin-like immunoreactivity recover...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91206-8
更新日期：1994-10-24 00:00:00
abstract：:The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91143-5
更新日期：1983-01-10 00:00:00
abstract：:We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91089-4
更新日期：1987-05-19 00:00:00
abstract：:To investigate whether atypical antipsychotic drugs exert an effect on the neuroprotective protein Bcl-2, rats were chronically treated with clozapine or olanzapine for 28 days. The expression of bcl-2 mRNA and Bcl-2 protein was determined, respectively, by in situ hybridization in tissue sections and Western blot on ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.064
更新日期：2004-06-04 00:00:00
abstract：:Horseradish peroxidase application in exsanguinated, pre-perfused newts, Pleurodeles waltlii, appeared to be very useful to study the connections of the area octavolateralis. Efferents from the octavolateral area course via bilateral lemnisci to the tectum and a presumptive torus semicircularis in the midbrain. Additi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90859-6
更新日期：1987-10-13 00:00:00
abstract：:The response of the endoneurial vasculature in rat sciatic nerve following crush injury was investigated by morphometric analysis of serial nerve transverse sections at the site of injury and in distal segments at 1, 2, 3, 6, and 9 weeks after injury. Quantitative analysis included determination of the number of vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90018-i
更新日期：1993-09-24 00:00:00
abstract：:Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90456-7
更新日期：1986-01-08 00:00:00
abstract：:In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90084-8
更新日期：1985-07-29 00:00:00
abstract：:Using the teased fiber recording method, we have compared pathophysiological properties of afferent axons injured in the infraorbital nerve (ION) vs the sciatic nerve in rats. Both myelinated and unmyelinated axons ending in ION neuromas produced much less ongoing discharge than those ending in sciatic nerve neuromas....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90753-v
更新日期：1992-05-01 00:00:00
abstract：:The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90342-8
更新日期：1987-05-05 00:00:00
abstract：:The effect of high concentrations of L-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91139-4
更新日期：1985-09-09 00:00:00
abstract：:Astrocytes provide structural, trophic and metabolic support to neurons and modulate synaptic activity. Under physiological conditions, neuronal-derived nitric oxide (NO) plays an important role in the modulation of a variety of central nervous system (CNS) functions. NO, although short lived, can travel sufficient di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.026
更新日期：2004-09-10 00:00:00
abstract：:Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90715-7
更新日期：1984-05-14 00:00:00
abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.048
更新日期：2006-08-04 00:00:00
abstract：:To better understand the contributions of effort on cortical activation associated with motor tasks, healthy participants with varying capacities for isolating the control of individual finger movements performed tasks consisting of a single concurrent abduction of all digits (Easy) and paired finger abduction with di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.005
更新日期：2009-12-08 00:00:00
abstract：:The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146798
更新日期：2020-07-01 00:00:00
abstract：:The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02598-7
更新日期：2001-07-27 00:00:00
abstract：:It has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. The data reviewed here, however, suggest that the oft-stated generalization that normal aging is characterized by disruption of cholinergic input to the hippoca...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(87)90007-5
更新日期：1987-11-01 00:00:00
