Microinjections of the gamma-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats.

abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...

journal_title：Brain research

authors： Riedel A,Klekamp J,Harper C,Kretschmann HJ

更新日期：1989-10-16 00:00:00

abstract：:Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...

journal_title：Brain research

authors： Louth EL,Luctkar HD,Heney KA,Bailey CDC

更新日期：2018-01-01 00:00:00

abstract：:How general anaesthetic drugs cause unconsciousness is a topic of ongoing clinical and scientific interest. It is becoming increasingly apparent that they disrupt cortical information processing, but the effects appear to depend on the spatial scale under investigation. In this study we investigated whether the intrav...

journal_title：Brain research

authors： Voss LJ,Baas CH,Hansson L,Li D,Sleigh JW

更新日期：2013-08-14 00:00:00

abstract：:Movement of fragmented DNA in dendrites of retinal neurons during the apoptotic cell death was investigated. The time-course of the movement of fragmented DNA in dendrites of retinal neurons undergoing apoptotic cell death induced by intravitreal N-methyl-d-aspartate (NMDA) injection were examined by in situ terminal ...

journal_title：Brain research

authors： Hara A,Niwa M,Kumada M,Kitaori N,Yamamoto T,Kozawa O,Mori H

更新日期：2004-05-08 00:00:00

abstract：:The cockroach can reduce the amount of sensory activity received by its CNS from the cerci, paired wind-responsive appendages. This reduction is produced by medial displacement of the cerci, a movement the animal performs naturally during flying. We demonstrate here that this sensory reduction significantly reduces ac...

journal_title：Brain research

authors： Goldstein RS,Camhi JM

更新日期：1988-02-09 00:00:00

abstract：:Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Studies reported in this paper...

journal_title：Brain research

authors： Shank RP,Bennett GS,Freytag SO,Campbell GL

更新日期：1985-03-11 00:00:00

abstract：:In albino rats the superior colliculus was stimulated and evoked potentials were explored in the cerebellar hemisphere including the paramedian lobule, and crura I and II. Climbing fiber responses were identified in a strip (ca. 1 mm wide) in the medial region of crus II, extending to both folia a and b. In the tector...

journal_title：Brain research

authors： Akaike T

更新日期：1986-07-16 00:00:00

abstract：:Sokoloff's [14C]2-deoxyglucose method has been applied to investigate circadian variations in local cerebral glucose utilization (LCGU). Freely moving rats were tested during two phases of the circadian light/dark cycle. In the rats tested during darkness, elevations in LCGU, when compared with animals tested during t...

journal_title：Brain research

authors： Room P,Tielemans AJ

更新日期：1989-12-29 00:00:00

abstract：:In cats ranging in age from the second week to adult, the postnatal functional development of striate cortical neurons projecting to the superior colliculus (SC) was studied by observing their visual responses, axonal conduction velocities and spontaneous activities. One-hundred-and-fifty-seven cells were identified a...

journal_title：Brain research

authors： Tsumoto T,Suda K

更新日期：1983-12-01 00:00:00

abstract：:The possibility of retinotopic organization of pathways of retinal fibers within the optic tract and the tectum of the frog was studied by selective labeling of the retinal fibers with horseradish peroxidase. Within the optic tract the pathways of the ventral, temporal and dorsal retinal fibers were ordered from the d...

journal_title：Brain research

authors： Fujisawa H,Watanabe K,Tani N,Ibata Y

更新日期：1981-02-09 00:00:00

abstract：:Disturbed synaptic transmission contributes to the pathophysiology of mood disorders. Post mortem studies reported reduced expression of the synaptic vesicle protein (SVP) complexins I and II in depression. Antidepressants were found to induce the expression of these genes. Since animals with congenital susceptibility...

journal_title：Brain research

authors： Zink M,Vollmayr B,Gebicke-Haerter PJ,Henn FA,Thome J

更新日期：2007-05-04 00:00:00

abstract：:Excitatory transmission along the perforant path from the entorhinal cortex to the granule cells of the dentate gyrus was evaluated two days after 10 min of transient cerebral ischemia in the rat. The amplitude of the population spike, and the amplitude and the initial slope of the population excitatory postsynaptic p...

journal_title：Brain research

authors： Chang HS,Steward O,Kassell NF

更新日期：1989-12-29 00:00:00

abstract：:In the striatum and hippocampus, there is a loss of sensitivity to muscarinic agonists with age which has been traced to events early in the signal transduction pathway. Our laboratory has therefore focussed on investigations at this level. The current experiments investigate the effects of age on G-protein/receptor i...

journal_title：Brain research

authors： Anson RM,Cutler R,Joseph JA,Yamagami K,Roth GS

更新日期：1992-12-11 00:00:00

abstract：:The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...

journal_title：Brain research

authors： Collingridge GL,Davies J

更新日期：1981-05-18 00:00:00

abstract：:Increases in extracellular potassium concentrations reliably increase burst rates in cultured fetal murine spinal cord networks. This effect could be mimicked by either blocking voltage-gated potassium conductances or facilitating excitatory synaptic interactions, but not by blocking specific calcium-dependent potassi...

journal_title：Brain research

authors： Rhoades BK,Gross GW

更新日期：1994-04-18 00:00:00

abstract：:Agents such as 619C89 decrease extracellular glutamate concentrations by a primary action at voltage sensitive sodium channels, but NMDA antagonists also have been shown to decrease extracellular glutamate concentration after ischemia. To address the question as to whether 619C89's effect upon extracellular glutamate ...

journal_title：Brain research

authors： Chen J,Graham SH,Simon RP

更新日期：1995-11-13 00:00:00

abstract：:Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...

journal_title：Brain research

authors： Tung NN,Morgan IG,Ehrlich D

更新日期：1987-12-01 00:00:00

abstract：:Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss...

journal_title：Brain research

authors： Han Z,Kuyatt BL,Kochman KA,DeSouza EB,Roth GS

更新日期：1989-10-02 00:00:00

abstract：:Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreact...

journal_title：Brain research

authors： Bowyer JF

更新日期：2000-12-08 00:00:00

abstract：:A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...

journal_title：Brain research

authors： Vicedomini JP,Nadler JV

更新日期：1990-03-26 00:00:00

abstract：:The development of the dorsal root potential (DRP) and the responsiveness of primary afferent fibers to gamma-aminobutyric acid (GABA) were investigated in the isolated spinal cord of rat fetuses. At embryonic day 15.5, stimulation of the lumbar dorsal root was first effective in eliciting the DRP, which was not inhib...

journal_title：Brain research

authors： Seno N,Saito K

更新日期：1985-01-01 00:00:00

abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...

journal_title：Brain research

authors： White SR,Penner JD,Speth RC,Chan JY

更新日期：1988-02-16 00:00:00

abstract：:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...

journal_title：Brain research

authors： Kasckow JW,Parkes DG,Owens MJ,Stipetic MD,Han JH,Nemeroff CB,Vale WW

更新日期：1994-08-15 00:00:00

abstract：:The extrafusal and intrafusal muscle fibers in the masseter muscle are innervated by motoneurons in the trigeminal motor nucleus (Mo 5). In the present study, we found that the number of trigeminal motor neurons in the male mouse was significantly larger than that in the female. However, we could not detect any signif...

journal_title：Brain research

authors： Maeda N,Sugiyama H,Suemune S,Wakisaka H,Niida S,Ogata K,Miyata K

更新日期：1993-11-05 00:00:00

abstract：:Evidence is presented for the occurrence of a unique opiate alkaloid-selective, opioid peptide-insensitive binding site in N18TG2 mouse neuroblastoma cells and in late passage hybrid F-11 cells, derived from N18TG2 neuroblastoma cells and rat dorsal root ganglion cells. Those cells lacked classical opioid peptide-sens...

journal_title：Brain research

authors： Cruciani RA,Dvorkin B,Klinger HP,Makman MH

更新日期：1994-12-26 00:00:00

abstract：:Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...

journal_title：Brain research

authors： Manzardo AM,Stein L,Belluzzi JD

更新日期：2002-01-04 00:00:00

abstract：:Male rats were treated with 10 mg/kg D-fenfluramine (DF) i.p., twice a day for 4 days. Five days later there was a strong reduction (70-100%) in the Bmax of [3H]citalopram binding and the Vmax of [3H]5-HT uptake in cortical and hippocampal synaptosomes; 2 months after the treatment these parameters were reduced by 40-...

journal_title：Brain research

authors： Gobbi M,Mancini L,Presti ML,Mennini T

更新日期：1996-08-19 00:00:00

abstract：:The origins of nitric oxide synthase (NOS)-containing nerve fibers in the rat basilar artery were studied by a combination of Fluoro-Gold retrograde tracing and immunohistochemistry. After application of Fluoro-Gold onto the middle part of the basilar artery, the dye accumulated in the sphenopalatine, otic, trigeminal...

journal_title：Brain research

authors： Kadota O,Matsuda S,Ohta S,Kumon Y,Sakaki S,Sakanaka M

更新日期：1996-01-08 00:00:00

abstract：:Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...

journal_title：Brain research

authors： Hochman S,Garraway SM,Pockett S

更新日期：1997-09-05 00:00:00

abstract：:The nigrostriatal projection was studied with a retrograde tracing method (Evans blue, EB) combined with a technique for dopamine histofluorescence. The study, realized in control rats and in animals with 6-hydroxydopamine-induced lesions of the dopaminergic pathway, yielded the following results. (1) In 3 control rat...

journal_title：Brain research

authors： Guyenet PG,Crane JK

更新日期：1981-06-01 00:00:00