Abstract：
:Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss during aging was 19%, and also varied considerably within the different striatal regions. Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
journal_name
Brain Resjournal_title
Brain researchauthors
Han Z,Kuyatt BL,Kochman KA,DeSouza EB,Roth GSdoi
10.1016/0006-8993(89)91108-6subject
Has Abstractpub_date
1989-10-02 00:00:00pages
299-307issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91108-6journal_volume
498pub_type
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