Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges.


:The ability of embryonic hippocampal tissue to promote regeneration of cholinergic axons in the septohippocampal system has been studied in adult rats. Strips of embryonic hippocampus, taken from 7-40 mm rat fetuses, were implanted into a 2-3 mm wide cavity which completely transected the septal cholinergic axons innervating the intrinsic hippocampus. The ingrowth of cholinergic fibres into the denervated host hippocampal formation was monitored by measuring the activity of the enzyme, choline acetyltransferase (ChAT), and by acetylcholine esterase (AChE) histochemistry. The results demonstrated a gradual, partial return of both ChAT enzyme activity and AChE-positive fibres in the initially denervated hippocampal formation of the adult recipient. Time-course studies indicated that this ingrowth progressed from the implant into the rostral tip of the host hippocampus, and continued caudally to cover the entire dorsal hippocampus by 3-6 months postoperative. Although the regenerating AChE-positive fibres reached the hippocampal target in the recipient along abnormal routes, they reinnervated selectively the appropriate terminal areas within the host hippocampus and dentate gyrus, suggesting the presence of quite specific mechanisms to guide the regenerating axons back to their original targets. Lesions of the medial septum-diagonal band area of the host and horseradish peroxidase (HRP) injections into the host hippocampus, caudal to the implant, indicated that the origin of the regenerating axons was predominately from the ipsilateral ventral medial septum and diagonal band area of the host. The results provide evidence that axonal regeneration and reinnervation of a denervated target zone can be promoted by utilizing implants of embryonic CNS tissue to bridge a tissue defect between the target and the lesioned axonal stumps.


Brain Res


Brain research


Kromer LF,Björklund A,Stenevi U




Has Abstract


1981-04-06 00:00:00














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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chavez-Noriega LE,Stevens CF

    更新日期:1992-03-06 00:00:00

  • Contribution of plasma membrane and endoplasmic reticulum Ca(2+)-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress.

    abstract::In the present study we analyzed the effect of ascorbate (0.8 mM)/Fe2+ (2.5 microM)-induced membrane lipid peroxidation on the levels of intracellular free calcium,[Ca2+]i and on the possible mechanisms involved in the perturbation of intracellular calcium homeostasis during oxidative stress. For this purpose, the inf...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pereira C,Ferreira C,Carvalho C,Oliveira C

    更新日期:1996-03-25 00:00:00

  • Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry. 2. Operational characteristics of the alpha 2 autoreceptor in the bed nucleus of stria terminalis, pars ventralis.

    abstract::Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Palij P,Stamford JA

    更新日期:1993-04-02 00:00:00

  • Sexual maturation modifies the GABAergic control of gonadotrophin secretion in female rats.

    abstract::Administration of aminooxyacetic acid, (an inhibitor of gamma-aminobutyric acid (GABA)-transaminase which enhances the hypothalamic GABA content) increased luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in prepubertal rats (16 days of age), and decreased the levels of these pituitary hormones i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Moguilevsky JA,Carbone S,Szwarcfarb B,Rondina D

    更新日期:1991-11-01 00:00:00

  • Regional node-like membrane specializations in non-myelinated axons of rat retinal nerve fiber layer.

    abstract::The axons in the nerve fiber layer (NFL) of the adult rat retina were examined by transmission electron microscopy. NFL axons range in size from 0.12 to about 2.0 microm, with a peak at 0.3-0.4 microm. In addition to conventional small mitochondria in the NFL axons contain some large ones, which are similar to astrocy...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hildebrand C,Waxman SG

    更新日期:1983-01-03 00:00:00

  • Forebrain and midbrain fiber tract formation during early development in Alligator embryos.

    abstract::The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...

    journal_title:Brain research

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    authors: Pritz MB

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    journal_title:Brain research

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    authors: Fyda DM,Cooper KE,Veale WL

    更新日期:1991-04-19 00:00:00

  • Interaction between descending paraventricular neurons and vagal motor neurons.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lawrence D,Pittman QJ

    更新日期:1985-04-15 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Missale C,Govoni S,Castelletti L,Spano PF,Trabucchi M

    更新日期:1983-02-28 00:00:00

  • Effects of sex steroids on beta-endorphin release from rat hypothalamus in vitro.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakano Y,Suda T,Sumitomo T,Tozawa F,Demura H

    更新日期:1991-07-05 00:00:00

  • Prenatal cocaine exposure accelerates morphological changes and transient expression of tyrosine hydroxylase in the cochlea of developing rats.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Trigueiros-Cunha N,Leão P,Renard N,Tavares MA,Eybalin M

    更新日期:2006-05-01 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Furukawa Y,Kobayashi M

    更新日期:1986-05-28 00:00:00

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    authors: Poling KR,Brunjes PC

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    journal_title:Brain research

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    authors: Belluardo N,Mudò G,Cella S,Bindoni M

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    journal_title:Brain research

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    authors: Florentino A,Varga K,Kunos G

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    authors: Ernsberger P,Arneric SP,Arango V,Reis DJ

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    journal_title:Brain research

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    journal_title:Brain research

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    authors: Dawbarn D,Allen SJ,Semenenko FM

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hawthorn J,Ang VT,Jenkins JS

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Asanuma H,Kosar E,Tsukahara N,Robinson H

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Amrein I,Slomianka L

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kwon OJ,Ju WK,Choi SH,Lee MY,Oh SJ,Chun MH

    更新日期:2000-03-31 00:00:00

  • Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

    更新日期:1984-01-16 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Westergren I,Johansson BB

    更新日期:1992-02-28 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schoofs L,Veelaert D,De Loof A,Huybrechts R,Isaac E

    更新日期:1998-03-02 00:00:00

  • Age-related changes in kynurenic acid production in rat brain.

    abstract::Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gramsbergen JB,Schmidt W,Turski WA,Schwarcz R

    更新日期:1992-08-14 00:00:00