Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges.

Abstract:

:The ability of embryonic hippocampal tissue to promote regeneration of cholinergic axons in the septohippocampal system has been studied in adult rats. Strips of embryonic hippocampus, taken from 7-40 mm rat fetuses, were implanted into a 2-3 mm wide cavity which completely transected the septal cholinergic axons innervating the intrinsic hippocampus. The ingrowth of cholinergic fibres into the denervated host hippocampal formation was monitored by measuring the activity of the enzyme, choline acetyltransferase (ChAT), and by acetylcholine esterase (AChE) histochemistry. The results demonstrated a gradual, partial return of both ChAT enzyme activity and AChE-positive fibres in the initially denervated hippocampal formation of the adult recipient. Time-course studies indicated that this ingrowth progressed from the implant into the rostral tip of the host hippocampus, and continued caudally to cover the entire dorsal hippocampus by 3-6 months postoperative. Although the regenerating AChE-positive fibres reached the hippocampal target in the recipient along abnormal routes, they reinnervated selectively the appropriate terminal areas within the host hippocampus and dentate gyrus, suggesting the presence of quite specific mechanisms to guide the regenerating axons back to their original targets. Lesions of the medial septum-diagonal band area of the host and horseradish peroxidase (HRP) injections into the host hippocampus, caudal to the implant, indicated that the origin of the regenerating axons was predominately from the ipsilateral ventral medial septum and diagonal band area of the host. The results provide evidence that axonal regeneration and reinnervation of a denervated target zone can be promoted by utilizing implants of embryonic CNS tissue to bridge a tissue defect between the target and the lesioned axonal stumps.

journal_name

Brain Res

journal_title

Brain research

authors

Kromer LF,Björklund A,Stenevi U

doi

10.1016/0006-8993(81)90893-3

subject

Has Abstract

pub_date

1981-04-06 00:00:00

pages

173-200

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)90893-3

journal_volume

210

pub_type

杂志文章
  • Modulation of synaptic efficacy in field CA1 of the rat hippocampus by forskolin.

    abstract::Activation of cAMP-dependent protein kinase (kinase A) has recently been shown to enhance responses evoked by stimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in cultured hippocampal pyramidal neurons. Here we report results of experiments designed to determine if activation of the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90803-h

    authors: Chavez-Noriega LE,Stevens CF

    更新日期:1992-03-06 00:00:00

  • Contribution of plasma membrane and endoplasmic reticulum Ca(2+)-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress.

    abstract::In the present study we analyzed the effect of ascorbate (0.8 mM)/Fe2+ (2.5 microM)-induced membrane lipid peroxidation on the levels of intracellular free calcium,[Ca2+]i and on the possible mechanisms involved in the perturbation of intracellular calcium homeostasis during oxidative stress. For this purpose, the inf...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01554-x

    authors: Pereira C,Ferreira C,Carvalho C,Oliveira C

    更新日期:1996-03-25 00:00:00

  • Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry. 2. Operational characteristics of the alpha 2 autoreceptor in the bed nucleus of stria terminalis, pars ventralis.

    abstract::Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91498-h

    authors: Palij P,Stamford JA

    更新日期:1993-04-02 00:00:00

  • Sexual maturation modifies the GABAergic control of gonadotrophin secretion in female rats.

    abstract::Administration of aminooxyacetic acid, (an inhibitor of gamma-aminobutyric acid (GABA)-transaminase which enhances the hypothalamic GABA content) increased luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in prepubertal rats (16 days of age), and decreased the levels of these pituitary hormones i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91508-x

    authors: Moguilevsky JA,Carbone S,Szwarcfarb B,Rondina D

    更新日期:1991-11-01 00:00:00

  • Regional node-like membrane specializations in non-myelinated axons of rat retinal nerve fiber layer.

    abstract::The axons in the nerve fiber layer (NFL) of the adult rat retina were examined by transmission electron microscopy. NFL axons range in size from 0.12 to about 2.0 microm, with a peak at 0.3-0.4 microm. In addition to conventional small mitochondria in the NFL axons contain some large ones, which are similar to astrocy...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91222-2

    authors: Hildebrand C,Waxman SG

    更新日期:1983-01-03 00:00:00

  • Forebrain and midbrain fiber tract formation during early development in Alligator embryos.

    abstract::The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.11.081

    authors: Pritz MB

    更新日期:2010-02-08 00:00:00

  • Modulation of brown adipose tissue-mediated thermogenesis by lesions to the nucleus tractus solitarius in the rat.

    abstract::Given that relatively little is known regarding the central control of brown adipose tissue (BAT)-mediated thermogenesis the present study assessed whether the direct pharmacological stimulation of beta- or alpha-adrenergic receptors located on the brown adipocytes would result in a typical thermogenic response follow...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91482-g

    authors: Fyda DM,Cooper KE,Veale WL

    更新日期:1991-04-19 00:00:00

  • Interaction between descending paraventricular neurons and vagal motor neurons.

    abstract::The hypothalamic paraventricular nucleus is known to send projections to the dorsal medullary area where it appears to innervate the nucleus tractus solitarius and the dorsal motor nucleus of the vagus. Experiments were carried out in urethane anesthetized rats to identify single vagal motor neurons identified by anti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90399-3

    authors: Lawrence D,Pittman QJ

    更新日期:1985-04-15 00:00:00

  • Age related changes of enkephalin in rat spinal cord.

    abstract::Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90481-x

    authors: Missale C,Govoni S,Castelletti L,Spano PF,Trabucchi M

    更新日期:1983-02-28 00:00:00

  • Effects of sex steroids on beta-endorphin release from rat hypothalamus in vitro.

    abstract::The effects of sex steroids on immunoreactive beta-endorphin (EP) release from the rat hypothalamus in vitro were examined using a rat hypothalamic perifusion system and an EP RIA. Testosterone (1-100 ng/ml) and estradiol (10-100 pg/ml) stimulated EP release in a dose-dependent manner. Dehydroepiandrosterone (DHEA, 1-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90221-g

    authors: Nakano Y,Suda T,Sumitomo T,Tozawa F,Demura H

    更新日期:1991-07-05 00:00:00

  • Prenatal cocaine exposure accelerates morphological changes and transient expression of tyrosine hydroxylase in the cochlea of developing rats.

    abstract::Prenatal cocaine exposure causes alterations in auditory brainstem response in children and experimental animals and has adverse effects on auditory information processing and language skills in children. These effects may result from lesions in the cochlea since this organ is particularly sensitive to chemical insult...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.02.066

    authors: Trigueiros-Cunha N,Leão P,Renard N,Tavares MA,Eybalin M

    更新日期:2006-05-01 00:00:00

  • Acetylcholine-induced hyperpolarization in identified neurones of the African giant snail (Achatina fulica Férussac).

    abstract::Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90416-6

    authors: Furukawa Y,Kobayashi M

    更新日期:1986-05-28 00:00:00

  • Sensory deafferentation and olfactory bulb morphology in the zebrafish and related species.

    abstract::The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02412-9

    authors: Poling KR,Brunjes PC

    更新日期:2000-02-21 00:00:00

  • Effect of cerebral hemisphere decortication on the cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse.

    abstract::A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90704-f

    authors: Belluardo N,Mudò G,Cella S,Bindoni M

    更新日期:1990-08-06 00:00:00

  • Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.

    abstract::The effects of baclofen microinjected into the nucleus tractus solitarii (NTS) on blood pressure, heart rate and baroreflex bradycardia were studied in urethane-anesthetized rats. Baclofen caused dose-dependent pressor and tachycardic effects and inhibited the reflex bradycardia elicited by i.v. phenylephrine. The eff...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91609-k

    authors: Florentino A,Varga K,Kunos G

    更新日期:1990-12-10 00:00:00

  • Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum.

    abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146968

    authors: Almeida LEF,Wang L,Kamimura S,Zerfas PM,Smith ML,Neto OLA,Vale T,Quezado MM,Horkayne-Szakaly I,Wakim P,Quezado ZMN

    更新日期:2020-11-01 00:00:00

  • Ether anesthesia differentially affects the content of prepro-corticotropin-releasing hormone, prepro-neurotensin/neuromedin N and prepro-enkephalin mRNAs in the hypothalamic paraventricular nucleus of the rat.

    abstract::The content of the mRNAs that code for prepro-corticotropin releasing hormone (ppCRH), prepro-neurotensin/neuromedin N (ppNT/NMN) and prepro-enkephalin (ppENK) was measured using in situ hybridization histochemistry in the various subdivisions of the hypothalamic paraventricular nucleus (PVH) 4 h after a bout of ether...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90080-f

    authors: Watts AG

    更新日期:1991-03-29 00:00:00

  • Membrane properties of rat magnocellular neuroendocrine cells in vivo.

    abstract::Membrane properties of rat magnocellular neuroendocrine cells (MNCs) were examined during intracellular recordings in vivo. Current-clamp experiments revealed sustained outward rectification positive to -55 mV and transient outward rectification of depolarizing responses elicited from negative holding potentials. Trai...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90535-4

    authors: Bourque CW,Renaud LP

    更新日期:1991-02-01 00:00:00

  • Quantitative distribution of muscarinic receptors and choline acetyltransferase in rat medulla: examination of transmitter-receptor mismatch.

    abstract::Recent reports have identified discrepancies between the anatomical distribution of transmitters and their receptors, a phenomenon known as transmitter-receptor mismatch. However, quantitative determinations of transmitter activity and receptor density in individual brain regions have not been conducted in parallel. W...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90038-8

    authors: Ernsberger P,Arneric SP,Arango V,Reis DJ

    更新日期:1988-06-14 00:00:00

  • Plectin immunopositivity appears in the astrocytes in the white matter but not in the gray matter after stab wounds.

    abstract::Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02399-9

    authors: Kálmán M,Szabó A

    更新日期:2000-02-28 00:00:00

  • Influences of hyperthermia-induced seizures on learning, memory and phosphorylative state of CaMKIIα in rat hippocampus.

    abstract::Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.02.026

    authors: Xiong Y,Zhou H,Zhang L

    更新日期:2014-04-04 00:00:00

  • Immunohistochemical localization of beta-nerve growth factor receptors in the forebrain of the rat.

    abstract::Using a monoclonal antibody (192-IgG) directed against the rat beta-nerve growth factor (beta-NGF) receptor the distribution of beta-NGF receptors in the forebrain of the rat has been determined. beta-NGF receptor-containing cells were located in presumed cholinergic cells of the medial septal nucleus, vertical and ho...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91175-4

    authors: Dawbarn D,Allen SJ,Semenenko FM

    更新日期:1988-02-02 00:00:00

  • Effects of lesions in the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei on vasopressin and oxytocin in rat brain and spinal cord.

    abstract::The content of arginine vasopressin and oxytocin in various extrahypothalamic sites of the rat brain and spinal cord was determined by specific radioimmunoassays after lesions had been made in either the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei (SCN). In some animals all 3 nuclei were destroye...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91093-5

    authors: Hawthorn J,Ang VT,Jenkins JS

    更新日期:1985-10-28 00:00:00

  • Modification of the projection from the sensory cortex to the motor cortex following the elimination of thalamic projections to the motor cortex in cats.

    abstract::Examination of the projection from area 2 of the sensory cortex to the motor cortex revealed substantial changes following lesion of the ventrolateral nucleus of the thalamus. These observed changes were as follows. (1) The polarity of the evoked potentials elicited by area 2 stimulation reversed in the depth of the m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90838-8

    authors: Asanuma H,Kosar E,Tsukahara N,Robinson H

    更新日期:1985-10-14 00:00:00

  • A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis.

    abstract::Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of doublecortin-positiv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.02.075

    authors: Amrein I,Slomianka L

    更新日期:2010-04-30 00:00:00

  • The expression and cellular localization of brain/kidney protein in the rat retina.

    abstract::Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02014-x

    authors: Kwon OJ,Ju WK,Choi SH,Lee MY,Oh SJ,Chun MH

    更新日期:2000-03-31 00:00:00

  • Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats.

    abstract::Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90665-6

    authors: Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

    更新日期:1984-01-16 00:00:00

  • NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema.

    abstract::Glutamate (2.5 mg) was administered after the blood-brain barrier had been opened by a unilateral intracarotid infusion of 5 mg protamine sulfate in rats. Whereas the brain specific gravity, measured 24 h later, did not differ between the injected and non-injected side after protamine alone, glutamate significantly re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90781-4

    authors: Westergren I,Johansson BB

    更新日期:1992-02-28 00:00:00

  • Immunocytochemical distribution of angiotensin I-converting enzyme-like immunoreactivity in the brain and testis of insects.

    abstract::Angiotensin converting enzyme (ACE) is Zn2+ metallopeptidase which plays an important role in blood pressure homeostasis in mammals and other vertebrates. Homologues of ACE involved in the biosynthesis of mammalian peptide hormones have also been identified in the insects, Musca domestica, Drosophila melanogaster and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01398-x

    authors: Schoofs L,Veelaert D,De Loof A,Huybrechts R,Isaac E

    更新日期:1998-03-02 00:00:00

  • Age-related changes in kynurenic acid production in rat brain.

    abstract::Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91337-e

    authors: Gramsbergen JB,Schmidt W,Turski WA,Schwarcz R

    更新日期:1992-08-14 00:00:00