Abstract:
:The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to CRD were measured to evaluate the sensitivity of visceral pain in rats. The sensitivity of visceral pain significantly increased in IBS-like rats. Expressions of spinal NR2B subunit and phosphorylated NR2B subunit significantly increased by 50-55% in IBS-like rats when compared with those in control rats. Ro 25-6981, a selective antagonist of NR2B subunit, has a dose-dependent anti-allodynic and anti-hyperalgesic effect without causing motor dysfunction in IBS-like rats. Furthermore, the activation mechanism of the spinal NR2B subunit in chronic visceral pain was also investigated. Spinal administration of genistein, a specific inhibitor of tyrosine kinases, also decreased the visceral pain hypersensitivity of IBS-like rats in a dose-dependent manner. In addition, the expression of phosphorylated NR2B subunit was decreased after spinal administration of Ro 25-6981 or genistein in IBS-like rats. In conclusion, tyrosine kinase activation-induced phosphorylation of NR2B subunit may play a crucial role in central sensitization of chronic visceral pain.
journal_name
Brain Resjournal_title
Brain researchauthors
Luo XQ,Cai QY,Chen Y,Guo LX,Chen AQ,Wu ZQ,Lin Cdoi
10.1016/j.brainres.2013.10.008subject
Has Abstractpub_date
2014-01-13 00:00:00pages
167-75eissn
0006-8993issn
1872-6240pii
S0006-8993(13)01371-1journal_volume
1542pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when is...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91332-b
更新日期:1990-08-13 00:00:00
abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91585-o
更新日期:1991-03-01 00:00:00
abstract::Oral ENA713 (0.5, 1.5 and 4.5 mg/kg), an acetylcholinesterase inhibitor (AChEI), dose-dependently enhanced extracellular acetylcholine concentrations in the hippocampus of freely moving rats. This effect was paralleled by changes in both noradrenergic and dopaminergic transmission. In particular, ENA713 significantly ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02266-6
更新日期:2000-05-26 00:00:00
abstract::Nestin is an intermediate filament protein, transiently and abundantly expressed early in embryogenesis, e.g., in neuroepithelial cells, radial glia, germinal matrix cells and vascular cells. In the adult rat brain, nestin is only present in endothelial and select subventricular cells. We tested the hypothesis that af...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01502-4
更新日期:1999-08-14 00:00:00
abstract::In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.02.029
更新日期:2018-05-15 00:00:00
abstract::Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91456-2
更新日期:1984-02-13 00:00:00
abstract::To determine whether post-traumatic seizure severity would be affected by the interval between seizures and head injury, we measured seizures after various times with or without fluid percussion brain injury (2atm fluid percussion injury; FPI). To determine efficacy of anti-seizure medication, we also determined if le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.04.013
更新日期:2016-07-01 00:00:00
abstract::Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90628-9
更新日期:1991-10-25 00:00:00
abstract::We reported earlier that overnight change in explicit memory is positively related to the change in sleep spindle activity (between a control and a learning night). However, it remained unclear whether this effect was restricted to good memory performers and whether a general association of sleep spindles and a "sleep...
journal_title:Brain research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brainres.2007.10.106
更新日期:2008-01-29 00:00:00
abstract::This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00856-l
更新日期:1995-10-23 00:00:00
abstract::The avian pineal exhibits a daily rhythm in the synthesis and secretion of the hormone, melatonin, which is involved in maintaining temporal order within the circadian system of some species. The pineal is richly innervated by sympathetic nerves which originate in the superior cervical ganglia (SCG) and, in the chicke...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90636-n
更新日期:1992-01-13 00:00:00
abstract::Seizure is a common acute and severe disease in infants and children. Recurrent seizures or persistent seizures may cause irreversible brain damage. Mitogen activated protein kinase (MAPK) signaling pathway is associated with an inflammatory response, however it's involvement in the pathological process of seizures is...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146932
更新日期:2020-10-15 00:00:00
abstract::Individual variability in the behavioral responsiveness to psychostimulant drugs is due, in part, to genetic factors. The present study investigated the effects of acute and repeated administrations of cocaine (0, 5, 10 or 20 mg/kg, i.p.) on locomotor activity in male and female rats from genetically distinct strains ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01742-4
更新日期:1999-09-18 00:00:00
abstract::Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.017
更新日期:2006-12-18 00:00:00
abstract::We quantified by microdensitometry the immunoreactivity (IR) to monoclonal antibodies (SP6, SP12, SP15 and SP18) against various synaptic proteins in the molecular layers of the dentate gyrus, CA4, CA3, CA1, subiculum and entorhinal cortex in Alzheimer's disease (AD), Lewy body variant of AD (LBV) and diffuse Lewy bod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91709-4
更新日期:1994-12-19 00:00:00
abstract::By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00557-7
更新日期:1995-09-04 00:00:00
abstract::Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00404-6
更新日期:1997-07-18 00:00:00
abstract::The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was sensitive to lesions induced by focal cerebral ischemia. Sprague-Dawley rats were pre-screened for startle reflex responses 3-6 days prior to surgery and there were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.065
更新日期:2005-01-25 00:00:00
abstract::In order to elucidate the roles of hippocampal nitric oxide (NO) synthesis in working and reference memory performance of rats, the effects of intrahippocampal injections of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on this behavior were examined with a three-panel runway task. In the worki...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91135-f
更新日期:1993-12-31 00:00:00
abstract::The neurotoxic effects of chronic ethanol exposure were investigated in rat hippocampus by electrophysiological analysis of the Schaffer collateral-commissural input to stratum radiatum of CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special diet at leas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90777-0
更新日期:1981-09-28 00:00:00
abstract::Although it is generally believed that the central projections of the retina in birds are entirely crossed, using wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) as an anterograde tracer, we have found that in normal posthatched chicks there is a small ipsilateral retinofugal projection to the dience...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90124-4
更新日期:1983-10-01 00:00:00
abstract::Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons conta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90013-2
更新日期:1988-05-01 00:00:00
abstract::Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90280-9
更新日期:1983-11-14 00:00:00
abstract::The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91715-9
更新日期:1994-12-19 00:00:00
abstract::Expression of the immediate-early gene c-fos, a marker of neuronal activation, was employed to localize brainstem neuronal populations functionally related to the expiration reflex (ER). Twelve spontaneously breathing, non-decerebrate, pentobarbital anesthetized cats were used. The level of Fos-like immunoreactivity (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.064
更新日期:2007-12-12 00:00:00
abstract::The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old. On average, C57BL/6J (35 to 190 d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.066
更新日期:2006-05-26 00:00:00
abstract::The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic group of motoneurons in Rexed's Lamina X of the lumbosacral spinal cord of the Mongolian gerbil. The SNB innervates the perineal musculature, the bulbocavernosus (BC), levator ani (LA), and external anal sphincter (EAS). Recent studies demonstrate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02949-9
更新日期:2002-10-25 00:00:00
abstract::EEG power spectra exhibit site-specific and state-related differences in specific frequency bands. In the present study we investigated the effect of total sleep deprivation on sleep EEG topography. Eight healthy, young, right-handed subjects were recorded during baseline sleep and recovery sleep after sleep deprivati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02796-2
更新日期:2001-09-21 00:00:00
abstract::Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.07.018
更新日期:2018-12-01 00:00:00
abstract::Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.042
更新日期:2009-12-11 00:00:00