Abstract：
:The role of thyrotropin releasing hormone (TRH) in the dorsal vagal complex (DVC) in mediating the enhanced gastric contractility induced by glutamate (100 pmol) microinjected into the raphe pallidus (Rpa) was investigated in urethane-anesthetized rats acutely implanted with miniature strain gauge force transducers on the corpus of the stomach. Glutamate-induced stimulation of gastric contractility was dose-dependently inhibited by bilateral microinjection into the DVC of TRH antibody (0.17, 0.85 or 1.7 micrograms/100 nl/site) but not by vehicle. TRH antibody microinjected into the dorsal medullary reticular field had no effect. These data indicate that activation of Rpa neurons by glutamate increases gastric motor function through TRH release in the DVC.
journal_name
Brain Resjournal_title
Brain researchauthors
Garrick T,Prince M,Yang H,Ohning G,Taché Ydoi
10.1016/0006-8993(94)91035-9subject
Has Abstractpub_date
1994-02-14 00:00:00pages
343-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91035-9journal_volume
636pub_type
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